Göran Ahlsén
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View article: How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition Open
The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alterna…
View article: Author response: How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition
Author response: How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The stochas…
View article: Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function Open
Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in establishing synaptic specificity in hippocampal CA1. In vivo…
View article: How clustered protocadherin binding specificity is tuned for neuronal self/non-self-recognition
How clustered protocadherin binding specificity is tuned for neuronal self/non-self-recognition Open
The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self/non-self- discrimination. cPcdhs form chains mediated by altern…
View article: Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior
Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior Open
Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the…
View article: DIP/Dpr interactions and the evolutionary design of specificity in protein families
DIP/Dpr interactions and the evolutionary design of specificity in protein families Open
Differential binding affinities among closely related protein family members underlie many biological phenomena, including cell-cell recognition. Drosophila DIP and Dpr proteins mediate neuronal targeting in the fly through highly specific…
View article: DIP/Dpr interactions and the evolutionary design of specificity in protein families
DIP/Dpr interactions and the evolutionary design of specificity in protein families Open
Differential binding affinities among closely related protein family members underlie many biological phenomena, including cell-cell recognition. Drosophila DIP and Dpr proteins mediate neuronal targeting in the fly through highly specific…
View article: Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity
Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity Open
Significance DNA sequence variants in the Tbk1 gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS). We report a functional study of 25 missense TBK1 mutations scattered across all structural domains. These mu…
View article: Synaptogenic activity of the axon guidance molecule Robo2 is critical for hippocampal circuit function
Synaptogenic activity of the axon guidance molecule Robo2 is critical for hippocampal circuit function Open
The developmental transition between axon guidance and synapse formation is critical for circuit assembly but still poorly understood at the molecular level. We hypothesized that this key transition could be regulated by axon guidance cues…
View article: Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior Open
Summary: Type II cadherins are cell-cell adhesion proteins critical for tissue patterning and neuronal targeting but whose molecular binding code remains poorly understood. Here, we delineate binding preferences for type II cadherin cell-a…
View article: Protocadherin <i>cis</i> -dimer architecture and recognition unit diversity
Protocadherin <i>cis</i> -dimer architecture and recognition unit diversity Open
Significance Pcdhs are cell surface homophilic recognition proteins expressed stochastically to assign individual identities to each neuron. These individual identities ensure repulsion between neurites from the same cell and ensure that n…
View article: γ-Protocadherin structural diversity and functional implications
γ-Protocadherin structural diversity and functional implications Open
Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie neuronal self-recognition. Here we report crystal structures of ectodomain fragments…
View article: Author response: γ-Protocadherin structural diversity and functional implications
Author response: γ-Protocadherin structural diversity and functional implications Open
Full text Figures and data Side by side Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Stochastic cell-surface exp…
View article: Molecular basis of sidekick-mediated cell-cell adhesion and specificity
Molecular basis of sidekick-mediated cell-cell adhesion and specificity Open
Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of retinal neurons. Sdks mediate cell-cell adhesion with homophilic specificity th…
View article: Author response: Molecular basis of sidekick-mediated cell-cell adhesion and specificity
Author response: Molecular basis of sidekick-mediated cell-cell adhesion and specificity Open
Full text Figures and data Side by side Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Sidekick (Sdk) 1 and 2 are related immunoglob…
View article: Structural basis of adhesive binding by desmocollins and desmogleins
Structural basis of adhesive binding by desmocollins and desmogleins Open
Significance Desmosomes are crucial for the integrity of tissues that undergo mechanical stress. Their intercellular attachments are assembled from desmogleins (Dsgs) and desmocollins (Dscs), two families of specialized cadherins whose str…