Göran Engberg
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View article: Effects of Heat Exposure on Kynurenine Pathway Metabolism—Comparison Between Exertional and Exogenous Heating of the Human Body
Effects of Heat Exposure on Kynurenine Pathway Metabolism—Comparison Between Exertional and Exogenous Heating of the Human Body Open
Background The kynurenine pathway (KP) plays a pivotal role in many diseases that involve distinct pathological mechanisms. Objectives Since KP metabolites are potential disease biomarkers, it is crucial to investigate their fluctuations u…
View article: Excess GDNF associates with a subtype of schizophrenia with enhanced dopamine and increased prefrontal dysfunction
Excess GDNF associates with a subtype of schizophrenia with enhanced dopamine and increased prefrontal dysfunction Open
Schizophrenia (SCZ) displays a heterogeneous etiology. In about half of the patients, first-episode psychosis (FEP) associates with increased levels of striatal dopamine (DA), while cognitive and negative symptoms associate with reduced DA…
View article: Cardiovascular protein profiling in patients with first-episode psychosis
Cardiovascular protein profiling in patients with first-episode psychosis Open
Patients with schizophrenia have a threefold higher mortality from cardiovascular disease than people in the general population. Atherosclerosis is linked to immune activation, a process tentatively entwined with the underlying pathophysio…
View article: Kynurenine Metabolites in CSF and Plasma in Healthy Males
Kynurenine Metabolites in CSF and Plasma in Healthy Males Open
In recent years, kynurenine metabolites generated by tryptophan catabolism have gained increasing attention in the context of brain diseases. The question of importance is whether there is a relationship between peripheral and central leve…
View article: Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia
Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia Open
Schizophrenia is a neurodevelopmental disorder characterized by an excessive loss of synapses. Recent data suggest that this is due to increased microglia-mediated synaptic pruning. Here, we utilize human induced pluripotent stem cell-deri…
View article: Disrupted‐in‐schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first‐episode psychosis
Disrupted‐in‐schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first‐episode psychosis Open
Aim The disrupted‐in‐schizophrenia 1 (DISC1) protein is a key regulator at the intersection of major signaling pathways relevant for adaptive behavior. It is prone to posttranslational changes such as misassembly and aggregation but the si…
View article: Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders
Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders Open
Objective: We previously reported that dual injections of lipopolysaccharide (LPS) in mice constitute a valuable tool for investigating the contribution of inflammation to psychotic disorders. The present study investigated how immune acti…
View article: CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance
CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance Open
The hypothesis of dopamine dysfunction in psychosis has evolved since the mid-twentieth century. However, clinical support from biochemical analysis of the transmitter in patients is still missing. The present study assessed dopamine and r…
View article: Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity
Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity Open
The levels of several peripheral immune markers, particularly those interfering with WNT/β-catenin signaling, were significantly higher in patients with FEP than in healthy controls and associated with illness severity.
View article: Disrupted-in-schizophrenia 1 (DISC1) protein aggregates in cerebrospinal fluid are elevated in first-episode psychosis patients
Disrupted-in-schizophrenia 1 (DISC1) protein aggregates in cerebrospinal fluid are elevated in first-episode psychosis patients Open
The Disrupted-in-schizophrenia 1 (DISC1) protein is a key regulator at the intersection of signaling pathways relevant for adaptive behavior. It is prone to posttranslational changes such as misassembly and aggregation but the significance…
View article: Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients Open
Psychotic disorders are currently diagnosed by examining the patient’s mental state and medical history. Identifying reliable diagnostic, monitoring, predictive, or prognostic biomarkers would be useful in clinical settings and help to und…
View article: Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia Open
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that increased expression of endogenous GDNF could induce dopaminer…
View article: Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia
Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia Open
Excessive synapse loss is a core feature of schizophrenia and is linked to the complement component 4A gene ( C4A ). In two independent cohorts, we show that cerebrospinal fluid (CSF) C4A concentration is elevated in first-episode psychosi…
View article: In Memoriam
In Memoriam Open
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View article: Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice Open
Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice with elevated levels of KYNA, induced…
View article: Torgny Svensson, a superb mind and an inspiring colleague
Torgny Svensson, a superb mind and an inspiring colleague Open
at the age of 75.He is grieved by his wife Louise and their children Martin, Jenny and Michael, and missed by many friends and colleagues in Sweden and around
View article: Pharmacological Treatment in Forensic Psychiatry—A Systematic Review
Pharmacological Treatment in Forensic Psychiatry—A Systematic Review Open
Background: Pharmacological treatment is of great importance in forensic psychiatry, and the vast majority of patients are treated with antipsychotic agents. There are several systematic differences between general and forensic psychiatric…
View article: Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid Open
Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolit…
View article: Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice Open
Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of N-methyl-d-aspartate (NMDA) receptors. Kynurenic acid levels are i…