Göran Larson
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View article: Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics
Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics Open
Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding an…
View article: Map of the neuronal O-glycoproteome reveals driver functions in the regulated secretory pathway
Map of the neuronal O-glycoproteome reveals driver functions in the regulated secretory pathway Open
Impairments in protein glycosylation, including O-GalNAc-type glycosylation, are linked to severe developmental disorders with prominent neurological involvement. However, the role of this glycosylation pathway at a cellular level is not y…
View article: Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics
Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics Open
Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding an…
View article: A Journey Through the Molecular Networks of Endomyocardial Biopsies To Explore ATTR and ALλ Cardiac Amyloidosis
A Journey Through the Molecular Networks of Endomyocardial Biopsies To Explore ATTR and ALλ Cardiac Amyloidosis Open
View article: N-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins
N-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins Open
Human noroviruses, globally the main cause of viral gastroenteritis, show strain specific affinity for histo-blood group antigens (HBGA) and can successfully be propagated ex vivo in human intestinal enteroids (HIEs). HIEs established from…
View article: Expression of influenza A virus glycan receptor candidates in mallard, chicken, and tufted duck
Expression of influenza A virus glycan receptor candidates in mallard, chicken, and tufted duck Open
Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further into mammals including humans. Receptor incompatibility due to differently expressed glycan structures between species ha…
View article: A glycomic workflow for LC–MS/MS analysis of urine glycosaminoglycan biomarkers in mucopolysaccharidoses
A glycomic workflow for LC–MS/MS analysis of urine glycosaminoglycan biomarkers in mucopolysaccharidoses Open
In recent years, several rational designed therapies have been developed for treatment of mucopolysaccharidoses (MPS), a group of inherited metabolic disorders in which glycosaminoglycans (GAGs) are accumulated in various tissues and organ…
View article: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics
Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics Open
View article: A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks
A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks Open
Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chicke…
View article: A glycomic workflow for LC-MS/MS analysis of urine glycosaminoglycan biomarkers in mucopolysaccharidoses
A glycomic workflow for LC-MS/MS analysis of urine glycosaminoglycan biomarkers in mucopolysaccharidoses Open
In recent years, several rational designed therapies have been developed for treatment of mucopolysaccharidoses (MPS), a group of inherited metabolic disorders in which glycosaminoglycans (GAGs) are accumulated in various tissues and organ…
View article: Subtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
Subtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies Open
Cardiac amyloidosis can be successfully subtyped without the prior enrichment of amyloid deposits with laser microdissection.
View article: Alterations in glycosaminoglycan biosynthesis associated with the Ehlers-Danlos syndromes
Alterations in glycosaminoglycan biosynthesis associated with the Ehlers-Danlos syndromes Open
Proteoglycans consist of a core protein substituted with one or more glycosaminoglycan (GAG) chains and execute versatile functions during many physiological and pathological processes. The biosynthesis of GAG chains is a complex process t…
View article: Site-specific glycosylation of proteoglycans: A revisited frontier in proteoglycan research
Site-specific glycosylation of proteoglycans: A revisited frontier in proteoglycan research Open
Proteoglycans (PGs), a class of carbohydrate-modified proteins, are present in essentially all metazoan organisms investigated to date. PGs are composed of glycosaminoglycan (GAG) chains attached to various core proteins and are important …
View article: Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for <scp>β3GalT6</scp>‐deficient spondylodysplastic <scp>Ehlers–Danlos</scp> syndrome
Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for <span>β3GalT6</span>‐deficient spondylodysplastic <span>Ehlers–Danlos</span> syndrome Open
The spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan …
View article: Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System
Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System Open
The Sda histo-blood group antigen (GalNAcβ1-4(NeuAcα2-3)Galβ-R) is implicated in various infections and constitutes a potential biomarker for colon cancer. Sd(a−) individuals (2–4% of Europeans) may produce anti-Sda, which can lead to inco…
View article: Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity
Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity Open
Sulfs represent a class of unconventional sulfatases which provide an original post-synthetic regulatory mechanism for heparan sulfate polysaccharides and are involved in multiple physiopathological processes, including cancer. However, Su…
View article: Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis
Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis Open
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View article: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis Open
View article: Glycan Recognition in Human Norovirus Infections
Glycan Recognition in Human Norovirus Infections Open
Recognition of cell-surface glycans is an important step in the attachment of several viruses to susceptible host cells. The molecular basis of glycan interactions and their functional consequences are well studied for human norovirus (HuN…
View article: Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context
Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context Open
View article: Expanding the Chondroitin Sulfate Glycoproteome — But How Far?
Expanding the Chondroitin Sulfate Glycoproteome — But How Far? Open
Chondroitin sulfate proteoglycans (CSPGs) are found at cell surfaces and in connective tissues, where they interact with a multitude of proteins involved in various pathophysiological processes. From a methodological perspective, the ident…
View article: Proteoglycan profiling of human, rat and mouse insulin-secreting cells
Proteoglycan profiling of human, rat and mouse insulin-secreting cells Open
Proteoglycans (PGs) are proteins with glycosaminoglycan (GAG) chains, such as chondroitin sulfate (CS) or heparan sulfate (HS), attached to serine residues. We have earlier shown that prohormones can carry CS, constituting a novel class of…
View article: Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum<i>N</i>- and<i>O</i>-Glycopeptide Data
Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum<i>N</i>- and<i>O</i>-Glycopeptide Data Open
Glycoproteome profiling (glycoproteomics) is a powerful yet analytically challenging research tool. The complex tandem mass spectra generated from glycopeptide mixtures require sophisticated analysis pipelines for structural determination.…
View article: Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity
Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity Open
Sulfs represent a class of unconventional sulfatases, which differ from all other members of the sulfatase family by their structures, catalytic features and biological functions. Through their specific endosulfatase activity in extracellu…
View article: Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans
Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans Open
Of all posttranslational modifications known, glycosaminoglycans (GAGs) remain one of the most challenging to study, and despite the recent years of advancement in MS technologies and bioinformatics, detailed knowledge about the complete s…
View article: Extracellular Endosulfatase Sulf-2 Harbours a Chondroitin/Dermatan Sulfate Chain That Modulates Its Enzyme Activity
Extracellular Endosulfatase Sulf-2 Harbours a Chondroitin/Dermatan Sulfate Chain That Modulates Its Enzyme Activity Open
View article: b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region
b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region Open
Proteoglycans are structurally and functionally diverse biomacromolecules found abundantly on cell membranes and in the extracellular matrix. They consist of a core protein linked to glycosaminoglycan chains via a tetrasaccharide linkage r…
View article: Revealing interspecies transmission barriers of avian influenza A viruses
Revealing interspecies transmission barriers of avian influenza A viruses Open
Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further to mammals including humans. Investigating molecular virus–host interactions dictating this process and the adaptations t…
View article: Both Lewis and Secretor Status Mediate Susceptibility to Rotavirus Infections in a Rotavirus Genotype–Dependent Manner
Both Lewis and Secretor Status Mediate Susceptibility to Rotavirus Infections in a Rotavirus Genotype–Dependent Manner Open
Background. The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histo–blood group antigens (HBGAs) in an RV genotype–dependent manner,…
View article: Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection
Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection Open