Göran Walldius
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View article: High apoB/apoA-1 ratio is a strong risk predictor of major adverse cardio- and cerebrovascular events part 2: a review basis for updating guidelines
High apoB/apoA-1 ratio is a strong risk predictor of major adverse cardio- and cerebrovascular events part 2: a review basis for updating guidelines Open
Strong associations between apoB, apoA-1 and especially the apoB/apoA-1 ratio and development of atherosclerosis-related risk of multiple CVD diseases have been documented world-wide. These data indicate that the balance, i.e. the ratio be…
View article: Dysglycaemia and incident aortic stenosis: a cohort study
Dysglycaemia and incident aortic stenosis: a cohort study Open
Background Aortic stenosis is a degenerative condition with high mortality in its severe stages and no preventive treatment. While diabetes is a known risk factor, the role of elevated glucose levels below the diabetic threshold in the dev…
View article: Lipids, apolipoproteins, carbohydrates, and risk of hematological malignancies
Lipids, apolipoproteins, carbohydrates, and risk of hematological malignancies Open
Previous studies have investigated the role of metabolic factors in risk of hematological malignancies with contradicting findings. Existing studies are generally limited by potential concern of reverse causality and confounding by inflamm…
View article: Improved prediction of 10‐year risk of severe liver disease in the general population using commonly available biomarkers
Improved prediction of 10‐year risk of severe liver disease in the general population using commonly available biomarkers Open
Summary Background Estimating the risk for cirrhosis in the general population is complex. Existing prediction tools are in general unsatisfactory. Aims To explore if using commonly available biomarkers can improve the commonly used FIB‐4 …
View article: Lipid levels in midlife and risk of atrial fibrillation over 3 decades—Experience from the Swedish AMORIS cohort: A cohort study
Lipid levels in midlife and risk of atrial fibrillation over 3 decades—Experience from the Swedish AMORIS cohort: A cohort study Open
Background The role of cholesterol levels in the development of atrial fibrillation (AF) is still controversial. In addition, whether and to what extent apolipoproteins are associated with the risk of AF is rarely studied. In this study, w…
View article: Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort
Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort Open
Objective: Type 1 diabetes is described to have an acute onset, but autoantibodies can appear several years preceding diagnosis. This suggests a long preclinical phase, which may also include metabolic parameters. Here we assessed whether …
View article: Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort
Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort Open
OBJECTIVE Type 1 diabetes is described to have an acute onset, but autoantibodies can appear several years preceding diagnosis. This suggests a long preclinical phase, which may also include metabolic parameters. Here we assessed whether e…
View article: Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort
Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort Open
Objective: Type 1 diabetes is described to have an acute onset, but autoantibodies can appear several years preceding diagnosis. This suggests a long preclinical phase, which may also include metabolic parameters. Here we assessed whether …
View article: Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio—Experience from the Swedish AMORIS cohort: A cohort study
Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio—Experience from the Swedish AMORIS cohort: A cohort study Open
Background Elevated apolipoprotein B (apoB) and elevated apoB/apoA-1 ratio increase the risk of myocardial infarction (MI) and stroke, whereas high apoA-1 is protective. We study how these apolipoproteins are associated with major adverse …
View article: Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis Open
Bilirubin has strong antioxidant properties that have been hypothesized to be preventive against the development of cancer. Thus, we aimed to investigate the association between serum total bilirubin (STB) and risk of overall and site-spec…
View article: Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study Open
Background Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explored the reciprocity b…
View article: Elevated Apolipoprotein B/A-1 Ratio is Associated With an Increased Risk of Aortic Stenosis: Experience From the AMORIS Cohort
Elevated Apolipoprotein B/A-1 Ratio is Associated With an Increased Risk of Aortic Stenosis: Experience From the AMORIS Cohort Open
An elevated apoB/apoA-1 ratio was associated with an increased incidence of AS, particularly in women and individuals aged ≥65 years, regardless of previous MACE.
View article: Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study Open
Background: Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explored the reciprocity …
View article: A Swedish primary healthcare prevention programme focusing on promotion of physical activity and a healthy lifestyle reduced cardiovascular events and mortality: 22-year follow-up of 5761 study participants and a reference group
A Swedish primary healthcare prevention programme focusing on promotion of physical activity and a healthy lifestyle reduced cardiovascular events and mortality: 22-year follow-up of 5761 study participants and a reference group Open
Objective To evaluate long-term risk of first cardiovascular (CV) events, CV deaths and all-cause deaths in community-dwelling participants of a cardiovascular disease (CVD) prevention programme delivered in a primary care setting. Methods…
View article: Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease
Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease Open
The fibrosis-4 scoring system is often used to estimate the risk of advanced fibrosis in liver diseases. Herein, we found that changes in this score over time are associated with the risk of future severe liver disease in a population-base…
View article: Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study Open
Background: Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral immune markers remains unclear. Thus, we explored the reciprocity between the…
View article: Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study
Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study Open
Background: Emerging evidence points to potential roles of the humoral immune responses in the development of pancreatic cancer. Epidemiological studies have suggested involvement of viral and bacterial infections in pancreatic carcinogene…
View article: Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study
Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study Open
Background: Relatively little is known about the role of the humoral immune system in melanoma. Tumor infiltrating B cells in melanoma patients have been associated with increased T cell activation in tumors as well as improved patient sur…
View article: Peripheral immune biomarkers and neurodegenerative diseases: A prospective cohort study with 20 years of follow‐up
Peripheral immune biomarkers and neurodegenerative diseases: A prospective cohort study with 20 years of follow‐up Open
Objective To assess the associations of several blood immune biomarkers with the future risks of amyotrophic lateral sclerosis and Parkinson disease in a prospective cohort study with 20 years of follow‐up. Methods The Swedish Apolipoprote…
View article: Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis
Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis Open
We present an innovative approach to risk stratify a well-defined population based on LCA metabolic-defined subgroups for cancer and mortality. Our results indicate that standard of care baseline serum markers, when assembled into meaningf…
View article: Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma
Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma Open
Immune and inflammatory cascades may play multiple roles in ovarian cancer. We aimed to identify relationships between expression of immune and inflammatory mediators and patient outcomes. We interrogated differential gene expression of 44…
View article: Serum immunoglobulin levels and the risk of bladder cancer in the AMORIS Cohort
Serum immunoglobulin levels and the risk of bladder cancer in the AMORIS Cohort Open
Event Abstract Back to Event Serum immunoglobulin levels and the risk of bladder cancer in the AMORIS Cohort Ioannis Peppas1*, Sam Sollie1, Debra H. Josephs1, Niklas Hammar2, Göran Walldius2, Sophia N. Karagiannis1 and Mieke Van Hemelrijck…
View article: Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study
Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study Open
Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.