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View article: On Energy Efficiency Characteristics of Laser Erosion on Oxidic Surfaces of Carbon Steels, Cast Iron and Low-alloy Non-ferrous Alloys During Deoxidizing Cleaning. Part II
On Energy Efficiency Characteristics of Laser Erosion on Oxidic Surfaces of Carbon Steels, Cast Iron and Low-alloy Non-ferrous Alloys During Deoxidizing Cleaning. Part II Open
An analysis of the energy efficiency characteristics was performed for laser erosion cleaning (LC) processes developed last period for the application in metalworking sector for the wide group of carbon steels, cast iron and non-ferrous me…
View article: Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes–Is rRNA Fragmentation Linked to Translational Fidelity?
Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes–Is rRNA Fragmentation Linked to Translational Fidelity? Open
Ribosomes are central to protein synthesis in all organisms. Among mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco display fragmented 28S rRNA, coupled with …
View article: Expression of the naked mole-rat transgene for Has2 improved health span in C57Bl/6 mice, but it did not attenuate age-related hearing loss.
Expression of the naked mole-rat transgene for Has2 improved health span in C57Bl/6 mice, but it did not attenuate age-related hearing loss. Open
The naked mole-rat (NMR) is renowned for being the longest-lived rodent, with a maximum lifespan of over 40 years. This exceptional longevity has been attributed to increased cytoprotective signaling, which has been partially ascribed to a…
View article: Advancing cancer research via comparative oncology
Advancing cancer research via comparative oncology Open
In the ongoing battle against cancer, the natural world provides promising inspiration for designing novel therapeutic strategies. The field of comparative oncology offers a valuable source of such inspiration. By combining evolutionary bi…
View article: Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair
Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair Open
Aging is marked by the accumulation of senescent cells (SnCs), which contribute to tissue dysfunction and age-related diseases. Senotherapeutics, including senolytics which specifically induce lysis of SnCs and senomorphics, which suppress…
View article: Mesenchymal stem cells and their derivatives as potential longevity-promoting tools
Mesenchymal stem cells and their derivatives as potential longevity-promoting tools Open
Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relat…
View article: SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice
SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice Open
SIRT6 is a protein deacylase, deacetylase, and mono-ADP-ribosylase (mADPr) regulating biological pathways important for longevity including DNA repair and silencing of LINE1 retrotransposons. SIRT6 knockout mice die by 30 days of age, wher…
View article: On Energy Efficiency Characteristics of Laser Erosion on Oxidic Surfaces of Carbon Steels, Cast Iron and Low-alloy Non-ferrous Alloys During Deoxidizing Cleaning. Part 1
On Energy Efficiency Characteristics of Laser Erosion on Oxidic Surfaces of Carbon Steels, Cast Iron and Low-alloy Non-ferrous Alloys During Deoxidizing Cleaning. Part 1 Open
A comparison of operating characteristics has been carried out for laser erosion cleaning (LC) processes studied in recent years and prospective for metalworking manufacturing of products/pieces from a number of carbon steels, cast iron an…
View article: Henipavirus in Northern Short-Tailed Shrew, Alabama, USA
Henipavirus in Northern Short-Tailed Shrew, Alabama, USA Open
RNA metagenomic analysis of tissues from 4 wild-caught northern short-tailed shrews in Alabama, USA, revealed a novel henipavirus (family Paramyxoviridae). Phylogenetic analysis supported the placement of the virus within the shrew henipav…
View article: Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and “Protein Age”
Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and “Protein Age” Open
Within a cell, proteins have distinct and highly variable half-lives. As a result, the molecular ages of proteins can range from seconds to years. How the age of a protein influences its environmental interactions is a largely unexplored a…
View article: Disagreement on foundational principles of biological aging
Disagreement on foundational principles of biological aging Open
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational is…
View article: cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation
cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation Open
Aging-associated inflammation, or ‘inflammaging” is a driver of multiple age-associated diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to activate interferon response upon detecting viral DNA in the cytop…
View article: LINE1 and its host: one cell’s junk is another cell’s treasure
LINE1 and its host: one cell’s junk is another cell’s treasure Open
LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 activation into mechanisms essential for …
View article: Epigenetic predictors of species maximum life span and other life-history traits in mammals
Epigenetic predictors of species maximum life span and other life-history traits in mammals Open
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span ( R = 0.89), gestation time ( R = 0.96), and age at sexual maturity ( R = 0.85). Our maximum life-span predictor indic…
View article: Data Sets Formation on the Physical Properties of Oxide Scale Components for Theoretical Assessment of Efficiency Parameters of Laser Cleaning of Carbon Steels and Related Processes
Data Sets Formation on the Physical Properties of Oxide Scale Components for Theoretical Assessment of Efficiency Parameters of Laser Cleaning of Carbon Steels and Related Processes Open
There is a need in machine-building industries nowadays to automate technologies, in particular, laser ones, to remove surface oxide layers – mill scale, rust – from steel products/pieces in order to improve the energy effectiveness of pro…