Guojuan Jiang
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View article: Analysis of the differences between HPV-independent and HPV-related cervical adenocarcinoma
Analysis of the differences between HPV-independent and HPV-related cervical adenocarcinoma Open
Background No prognostic evaluation criteria have been established for either human papillomavirus (HPV)-related cervical adenocarcinoma (HPV-CA) or HPV-independent cervical adenocarcinoma (HPV-Ind-CA). We aimed to compare and analyze the …
View article: Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics
Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics Open
Background Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers. The aim of this study is…
View article: Genomic and transcriptomic characteristics of 12 novel primary cell lines derived from three patients with cholangiocarcinoma
Genomic and transcriptomic characteristics of 12 novel primary cell lines derived from three patients with cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is an aggressive bile duct malignancy with poor prognosis. To improve our understanding of the biological characteristics of CCA and develop effective therapies, appropriate preclinical models are required. Here, w…
View article: Single-cell transcriptomics reveal the heterogeneity and dynamic of cancer stem-like cells during breast tumor progression
Single-cell transcriptomics reveal the heterogeneity and dynamic of cancer stem-like cells during breast tumor progression Open
Breast cancer stem-like cells (BCSCs) play vital roles in tumorigenesis and progression. However, the origin and dynamic changes of BCSCs are still to be elucidated. Using the breast cancer mouse model MMTV-PyMT, we constructed a single-ce…
View article: Interfering MSN-NONO complex–activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer
Interfering MSN-NONO complex–activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer Open
MSN and NONO and their interaction-activated CREB signaling pathway may be new targets for the treatment and prognosis of TNBC.
View article: General mechanism of JQ1 in inhibiting various types of cancer
General mechanism of JQ1 in inhibiting various types of cancer Open
Bromodomain‑containing 4 (BRD4) is a histone modification reader and transcriptional regulator that has been reported to interact with acetylated lysine histone motifs transcription factors (TFs), transcription co‑activators and RNA polyme…
View article: Cooperativity of co-factor NR2F2 with Pioneer Factors GATA3, FOXA1 in promoting ERα function
Cooperativity of co-factor NR2F2 with Pioneer Factors GATA3, FOXA1 in promoting ERα function Open
Estrogen receptor α (ERα) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcriptional events that promote tumor growth. ERα binding activity largely depends on access to binding site…
View article: MOESM3 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą
MOESM3 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą Open
Additional file 3. Differentially expressed genes between KDM3B-knockdown NB4 versus scrambled control NB4 cells followed with ATRA treatment.
View article: MOESM4 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą
MOESM4 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą Open
Additional file 4. Differentially expressed genes between ATRA-induced differentiated control NB4 versus undifferentiated NB4 cells.
View article: MOESM5 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą
MOESM5 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą Open
Additional file 5. PML/RARÎą-KDM3B coregulated 29-genes signature.
View article: MOESM1 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą
MOESM1 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą Open
Additional file 1. Quantitative PCR primers and details of antibodies.
View article: MOESM2 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą
MOESM2 of KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARÎą Open
Additional file 2. Differentially expressed genes between KDM3B-knockdown NB4 versus scrambled control NB4 cells.