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A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury Open

Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu , et al. · 2019

Aim Imbalances in cytochrome P450 (CYP)‐dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20‐hydroxyeicosatetraenoic acid (20‐HETE) action ameliorated is…

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice Open

Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner , et al. · 2016

These results indicate that the potential beneficial effects of reducing EET degradation were obliterated by a thus far unknown mechanism leading to kidney-specific up-regulation of 20-HETE formation in sEH-KO-mice.