Brett Hughes
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Comparison of Prophylactic Versus Reactive Tube Feeding Approaches on Weight Loss and Unplanned Hospital Admissions in Patients with Head and Neck Cancer Receiving Chemoradiotherapy Open
The study’s aim was to compare the unplanned admission rates and nutrition outcomes in patients with head and neck squamous cell cancer (HNSCC) receiving chemoradiotherapy at two different hospitals with different nutrition support approac…
Extended follow-up outcomes of patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab on EMPOWER-CSCC-1: A retrospective cohort study Open
Long-term follow-up confirms durable responses with cemiplimab in patients with advanced cutaneous squamous cell carcinoma in Australia treated on the EMPOWER-CSCC-1 trial.
Development of a circulating tumour cell culture model from head and neck squamous cell carcinoma Open
Despite the advancements made in the diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC), metastasis remains the primary cause of cancer‐related deaths. Circulating tumour cells (CTCs) may offer a valuable platform for…
View article: Health-related quality of life outcomes from KEYNOTE-412: chemoradiotherapy with or without pembrolizumab in participants with head and neck squamous cell carcinoma
Health-related quality of life outcomes from KEYNOTE-412: chemoradiotherapy with or without pembrolizumab in participants with head and neck squamous cell carcinoma Open
Background The health-related quality of life (HRQoL) of patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC) is impacted by both disease- and treatment-related factors. Treatments that preserve and maximize HRQo…
Tumour‐informed workflow to use ctDNA as a biomarker for risk of recurrence in head and neck cancer patients post‐treatment Open
Circulating tumour DNA (ctDNA) is a promising minimally invasive biomarker for monitoring treatment response in cancer patients. In this study, we developed a tumour‐informed workflow to enhance the detection of recurrence in head and neck…
View article: Intracranial activity of sotorasib vs docetaxel in pretreated KRAS G12C-mutated advanced non-small cell lung cancer from a global, phase 3, randomized controlled trial
Intracranial activity of sotorasib vs docetaxel in pretreated KRAS G12C-mutated advanced non-small cell lung cancer from a global, phase 3, randomized controlled trial Open
NCT04303780.
View article: The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment
The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment Open
Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease that accounts for an estimated 890,000 new cases per year. Despite advancements in chemotherapy, radiotherapy, surgery and immunotherapy, the prognosis of HNSCC has re…
Survival After Orbital Exenteration for Primary Cutaneous Squamous Cell Carcinoma: A Retrospective Cohort Study Open
Background Locally advanced periorbital cutaneous squamous cell carcinoma (cSCC) may require orbital exenteration, which is highly morbid. As immunotherapy develops, orbit preservation may become widespread, and data benchmarking survival …
View article: Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy
Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy Open
Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers…
View article: Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer
Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer Open
Background Head and neck squamous cell carcinoma (HNSCC) is linked to human papillomavirus (HPV) infection. HPV‐positive and HPV‐negative HNSCC exhibit distinct molecular and clinical characteristics. Although checkpoint inhibitors have sh…
Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response Open
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis [1]. With approximately one million new cases projecte…
Revalidation of Proactive Gastrostomy Tube Placement Guidelines for Head and Neck Cancer Patients Receiving Helical Intensity-Modulated Radiotherapy Open
The Royal Brisbane and Women’s Hospital (RBWH) Swallowing and Nutrition Management Guidelines for Patients with Head and Neck Cancer were developed to enable evidence-based decision-making by the Head and Neck Multidisciplinary Team (H&N M…
Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response Open
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis [1]. With approximately one million new cases projecte…
View article: Impact of Bone Metastasis in Stage IV Non–Small Cell Lung Cancer Treated With Durvalumab and Tremelimumab With or Without Chemotherapy: A Retrospective Analysis of the CCTG BR.34 Trial
Impact of Bone Metastasis in Stage IV Non–Small Cell Lung Cancer Treated With Durvalumab and Tremelimumab With or Without Chemotherapy: A Retrospective Analysis of the CCTG BR.34 Trial Open
PURPOSE This retrospective analysis examines the impact of bone metastasis on outcomes in patients with non–small cell lung cancer (NSCLC) from the CCTG BR.34 trial, which investigated the combined immune checkpoint blockade. MATERIALS AND…
The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment Open
Mucosal head and neck squamous cell carcinoma (HNSCC) is a debilitating disease that accounts for an estimated 890,000 new cases per year, making it the seventh most common cancer globally. HNSCC is a heterogenous group of cancers that aff…
A phase Ib study to assess the safety of the human papillomavirus DNA vaccine (AMV002) in combination with durvalumab for HPV-associated oropharyngeal squamous cell carcinoma Open
Background Programmed cell death ligand 1 (PD-L1) inhibitors have limited efficacy as monotherapy in patients with recurrent/metastatic (R/M) Human Papilloma Virus (HPV) oropharyngeal squamous cell carcinoma (OPSCC). A phase I study of the…
Real‐world outcomes for patients with pleural mesothelioma: A multisite retrospective cohort study Open
Aim To evaluate the real‐world treatment patterns and outcomes for patients with pleural mesothelioma (PM) in the era of immunotherapy. Methods This retrospective audit included patients with PM diagnosed within three tertiary referral cen…