Gordon Dougan
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View article: Rapid and relaying deleterious effects of a gastrointestinal pathogen, Citrobacter rodentium, on bone, an extra-intestinal organ
Rapid and relaying deleterious effects of a gastrointestinal pathogen, Citrobacter rodentium, on bone, an extra-intestinal organ Open
Enteropathogenic infections cause pathophysiological changes in the host but their effects beyond the gastrointestinal tract are undefined. Here, using Citrobacter rodentium infection in mouse, which mimics human diarrheal enteropat…
View article: Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumannii
Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumannii Open
The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that may prevent infection cause…
View article: Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes
Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes Open
Pneumonia is the leading infectious disease killer worldwide and commonly requires admission to critical care. Despite its prevalence, the underpinning biology of severe pneumonia remains incompletely understood. We performed multifaceted …
View article: Characterization of mAbs against <i>Klebsiella pneumoniae</i> type 3 fimbriae isolated in a target-independent phage display campaign
Characterization of mAbs against <i>Klebsiella pneumoniae</i> type 3 fimbriae isolated in a target-independent phage display campaign Open
We used phage display, antibody engineering, and high-throughput assays to identify antibody-accessible targets of Klebsiella pneumoniae . We report the discovery of monoclonal antibodies (mAbs) binding to type 3 fimbrial proteins, includi…
View article: Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis
Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis Open
View article: Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study
Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study Open
Fleming Fund, UK Department of Health and Social Care; Wellcome Trust; and Bill and Melinda Gates Foundation.
View article: Detecting Residual Chronic <i>Salmonella</i> Typhi Carriers on the Road to Typhoid Elimination in Santiago, Chile, 2017–2019
Detecting Residual Chronic <i>Salmonella</i> Typhi Carriers on the Road to Typhoid Elimination in Santiago, Chile, 2017–2019 Open
Background In Santiago, Chile, where typhoid had been hyperendemic (1977–1991), we investigated whether residual chronic carriers could be detected among household contacts of non-travel-related typhoid cases occurring during 2017–2019. Me…
View article: Vaccination to Reduce Antimicrobial Resistance Burden—Data Gaps and Future Research
Vaccination to Reduce Antimicrobial Resistance Burden—Data Gaps and Future Research Open
Antimicrobial resistance (AMR) poses an immediate danger to global health. If unaddressed, the current upsurge in AMR threatens to reverse the achievements in reducing the infectious disease–associated mortality and morbidity associated wi…
View article: Epidemiology and Risk Factors for Diarrheagenic Escherichia coli Carriage among Children in Northern Ibadan, Nigeria
Epidemiology and Risk Factors for Diarrheagenic Escherichia coli Carriage among Children in Northern Ibadan, Nigeria Open
Diarrhea is a leading cause of childhood morbidity in Africa, but few studies, focus on bacterial diarrheal etiology including multicountry studies that typically excluded Nigeria. We collected stool specimens from 477 children under 5 yea…
View article: Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in clinical isolates of Salmonella Typhimurium
Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in clinical isolates of Salmonella Typhimurium Open
Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Presently we rely on exposing single organisms to an antimicrobial and growth to determine susceptibility; throughput and interpretation h…
View article: Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load
Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load Open
View article: Inter-species gene flow drives ongoing evolution of<i>Streptococcus pyogenes</i>and<i>Streptococcus dysgalactiae</i>subsp.<i>equisimilis</i>
Inter-species gene flow drives ongoing evolution of<i>Streptococcus pyogenes</i>and<i>Streptococcus dysgalactiae</i>subsp.<i>equisimilis</i> Open
Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes . Through systematic…
View article: Salmonella Typhi whole genome sequencing in Rwanda shows a diverse historical population with recent introduction of haplotype H58
Salmonella Typhi whole genome sequencing in Rwanda shows a diverse historical population with recent introduction of haplotype H58 Open
Salmonella enterica serovar Typhi ( S . Typhi) is the cause of typhoid fever, presenting high rates of morbidity and mortality in low- and middle-income countries. The H58 haplotype shows high levels of antimicrobial resistance (AMR) and i…
View article: A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia
A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia Open
View article: The clinical, genomic, and microbiological profile of invasive multi-drug resistant Escherichia coli in a major teaching hospital in the United Kingdom
The clinical, genomic, and microbiological profile of invasive multi-drug resistant Escherichia coli in a major teaching hospital in the United Kingdom Open
Escherichia coli is a ubiquitous component of the human gut microbiome, but is also a common pathogen, causing around 40,000 bloodstream infections (BSI) in the UK annually. The number of E. coli BSI has increased over the last decade in t…
View article: Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae
Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae Open
To kill bacteria, bacteriophages (phages) must first bind to a receptor, triggering the release of the phage DNA into the bacterial cell. Many bacteria secrete polysaccharides that had been thought to shield bacterial cells from phage atta…
View article: Data from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Data from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
A major obstacle for the development of effective immunotherapy is the ability of tumors to escape the immune system. The possibility to kill tumor cells because they are recognized as infected rather than as malignant could help overcome …
View article: Supplementary Table 4 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Table 4 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Table 4 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 3 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 3 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 3 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Table 4 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Table 4 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Table 4 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 1 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 1 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 1 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 1 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 1 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 1 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure Legends 2A and 2B from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure Legends 2A and 2B from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure Legends 2A and 2B from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 5 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 5 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 5 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 5 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 5 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 5 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Data from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Data from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
A major obstacle for the development of effective immunotherapy is the ability of tumors to escape the immune system. The possibility to kill tumor cells because they are recognized as infected rather than as malignant could help overcome …
View article: Supplementary Figure 2A from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 2A from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 2A from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
View article: Supplementary Figure 2 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells
Supplementary Figure 2 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells Open
Supplementary Figure 2 from Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells