Gordon Murray
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View article: Bioelectric properties and ion flow across excised human bronchi
Bioelectric properties and ion flow across excised human bronchi Open
Bioelectric properties and ion transport of excised human segmental/subsegmental bronchi were measured in specimens from 40 patients. Transepithelial electric potential difference (PD), short-circuit current [I(sc)], and conductance (G), a…
View article: Cultivating Undergraduate Scientific Writing Proficiency through Interactive Video Workshops
Cultivating Undergraduate Scientific Writing Proficiency through Interactive Video Workshops Open
View article: Accuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom
Accuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom Open
View article: Insulin resistance alters the coupling between cerebral blood flow and glucose metabolism in younger and older adults: Implications for neurovascular coupling
Insulin resistance alters the coupling between cerebral blood flow and glucose metabolism in younger and older adults: Implications for neurovascular coupling Open
Rising rates of insulin resistance and an ageing population are set to exact an increasing toll on individuals and society. Here we examine the contribution of insulin resistance and age to the coupling of cerebral blood flow and glucose m…
View article: A-385 A Point-of-Care Test to Assess Vaccine Response and Recent Infection by Quantitative Measurement of Neutralizing Antibody, Anti-Nucleocapsid, and Anti-Spike Levels
A-385 A Point-of-Care Test to Assess Vaccine Response and Recent Infection by Quantitative Measurement of Neutralizing Antibody, Anti-Nucleocapsid, and Anti-Spike Levels Open
Background Following vaccination against SARS-CoV-2 (SC2), the human immune system produces neutralizing antibodies (NAb) that block the virus from entering host cells. These NAb levels are highly predictive of protection against SC2 infec…
View article: Cancer pain assessment and management: does an institutional approach individualise and reduce cost of care?
Cancer pain assessment and management: does an institutional approach individualise and reduce cost of care? Open
Objectives To understand individual prescribing and associated costs in patients managed with the Edinburgh Pain Assessment and management Tool (EPAT). Methods The EPAT study was a two-arm parallel group cluster randomised (1:1) trial, inc…
View article: Fungal Resistance and Leaching Behavior of Wood Treated with Creosote Diluted with a Mixture of Biodiesel and Diesel
Fungal Resistance and Leaching Behavior of Wood Treated with Creosote Diluted with a Mixture of Biodiesel and Diesel Open
This study evaluated the effect of biodiesel as a co-solvent with the wood preservative creosote to reduce the amount of hydrocarbon-based carrier utilized. Small blocks of wood were treated at a pilot scale using three different creosote …
View article: Application of Process Hazard Analysis and Inherently Safer Design in Wood Pellet Production
Application of Process Hazard Analysis and Inherently Safer Design in Wood Pellet Production Open
Wood pellets are a fuel used for heat and power generation. Wood pellets are manufactured from forest residues and byproducts of other sectors in the wood processing industry, such as sawmilling. Wood pellet production generates combustibl…
View article: An international, open-label, randomised trial comparing a two-step approach versus the standard three-step approach of the WHO analgesic ladder in patients with cancer
An international, open-label, randomised trial comparing a two-step approach versus the standard three-step approach of the WHO analgesic ladder in patients with cancer Open
View article: Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months
Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months Open
ISRCTN Identifier: 66202560.
View article: Plates
Plates Open
View article: Therapy-Related Mixed Phenotype Acute Leukemia: Report of two cases with clinicopathological and molecular data
Therapy-Related Mixed Phenotype Acute Leukemia: Report of two cases with clinicopathological and molecular data Open
Introduction/Objective Therapy-related mixed phenotype acute leukemia (Tr-MPAL) is a rare and aggressive disease comprising blast cells of more than one hematopoietic cell lineage. There is limited patient outcome data with this diagnosis.…
View article: Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage
Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage Open
isrctn.org Identifier: ISRCTN71907627.
View article: Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events
Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events Open
The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and F…
View article: Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial
Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial Open
View article: Targeting rehabilitation to improve outcomes after total knee arthroplasty in patients at risk of poor outcomes: randomised controlled trial
Targeting rehabilitation to improve outcomes after total knee arthroplasty in patients at risk of poor outcomes: randomised controlled trial Open
Objective To evaluate whether a progressive course of outpatient physiotherapy offers superior outcomes to a single physiotherapy review and home exercise based intervention when targeted at patients with a predicted poor outcome after tot…
View article: A practical method for dealing with missing Glasgow Coma Scale verbal component scores
A practical method for dealing with missing Glasgow Coma Scale verbal component scores Open
OBJECTIVE The Glasgow Coma Scale (GCS) is used for the assessment of impaired consciousness; however, it is not always possible to test each component, most commonly the verbal component. This affects the derivation of the GCS sum score, w…
View article: Response to: Effects of Alendronic Acid on Fracture Healing
Response to: Effects of Alendronic Acid on Fracture Healing Open
View article: Unreported Summary Statistics in Trial Publications and Risk of Bias in Stroke Rehabilitation Systematic Reviews: An International Survey of Review Authors and Examination of Practical Solutions
Unreported Summary Statistics in Trial Publications and Risk of Bias in Stroke Rehabilitation Systematic Reviews: An International Survey of Review Authors and Examination of Practical Solutions Open
Objective: Continuous outcome measures are essential in rehabilitation research. Incomplete reporting of their mean and standard deviation, required for meta-analysis, potentially introduces bias and imprecision if it prevents studies bein…
View article: Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent<i>SQSTM1</i>-mediated Paget’s disease of bone
Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent<i>SQSTM1</i>-mediated Paget’s disease of bone Open
Introduction Paget’s disease of bone (PDB) is characterised by increased and disorganised bone remodelling affecting one or more skeletal sites. Complications include bone pain, deformity, deafness and pathological fractures. Mutations in …
View article: The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial
The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial Open
View article: Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial Open
View article: Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial Open
View article: The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial Open
View article: Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial
Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial Open
There is a concern that bisphosphonates may impair fracture healing because of their inhibitory effects on bone turnover. Here we evaluated the effects of early bisphosphonate therapy on fracture healing and functional outcome following a …
View article: The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial Open
Background: For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the IC…
View article: The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial Open
Background: For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the IC…
View article: Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT
Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT Open
Background Traumatic brain injury (TBI) is a major cause of disability and death in young adults worldwide. It results in around 1 million hospital admissions annually in the European Union (EU), causes a majority of the 50,000 deaths from…
View article: Simplifying the use of prognostic information in traumatic brain injury. Part 2: Graphical presentation of probabilities
Simplifying the use of prognostic information in traumatic brain injury. Part 2: Graphical presentation of probabilities Open
OBJECTIVE Clinical features such as those included in the Glasgow Coma Scale (GCS) score, pupil reactivity, and patient age, as well as CT findings, have clear established relationships with patient outcomes due to neurotrauma. Nevertheles…
View article: Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity
Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity Open
OBJECTIVE Glasgow Coma Scale (GCS) scores and pupil responses are key indicators of the severity of traumatic brain damage. The aim of this study was to determine what information would be gained by combining these indicators into a single…