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CD8+ T cell recognition of cyst-derived antigen during chronic CNS infection with Toxoplasma gondii 4698 Open

Gordon Ruthel, Breanne E. Haskins, Sebastian Lourido · 2025

Description Toxoplasma gondii parasites establish persistent infection within neurons by forming cysts containing latent form bradyzoites. Given the limited MHC-I expression by neurons, it was previously thought that both neurons and cysts…

Equine Bone Marrow–Derived MSCs and Their EVs Exhibit Different Immunomodulatory Effects on Cartilage Explants in an <i>In Vitro</i> Osteoarthritis Model Open

Angela M. Gaesser, Justine M. Cianci, Kayla M. Even, Renata L. Linardi, Gordon Ruthel , et al. · 2025

Objective To compare the effects of equine MSCs and their extracellular vesicles (EV) on stimulated cartilage explants and assess how serum type influences EV production and cartilage inflammation. Methods EVs were isolated from bone marro…

Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration Open

Allen S. W. Oak, Amrit Bagchi, Matthew J. Brukman, Joshua Toth, Jamie Ford , et al. · 2025

Most wounds form scars without hair follicles. However, in the wound-induced hair neogenesis (WIHN) model of skin regeneration, wounds regenerate hair follicles if tissue rigidity is optimal. Although WIHN depends on Wnt signaling, whether…

Supplementary Data Tables S1-S2 from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2023

Supplemental Table S1: Patient Characteristics by UGCG expression defined Risk Groups in the Learning Dataset; Supplemental Table S2: Patient Characteristics by UGCG expression defined Risk Groups in the Validation Dataset (Cirenajwis et a…

Supplementary Data Figures S1-S5 from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2023

Supplemental Figure S1: LAI remodels the lipidome of melanoma cells. Supplemental Figure S2: LAI induces UGCG, and UGCG inhibition augments DC661 cytotoxicity, and this effect is not seen by blocking cholesterol synthesis and key earlier s…

Supplementary Data Tables S1-S2 from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2023

Supplemental Table S1: Patient Characteristics by UGCG expression defined Risk Groups in the Learning Dataset; Supplemental Table S2: Patient Characteristics by UGCG expression defined Risk Groups in the Validation Dataset (Cirenajwis et a…

Data from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2023

Lysosomal autophagy inhibition (LAI) with hydroxychloroquine or DC661 can enhance cancer therapy, but tumor regrowth is common. To elucidate LAI resistance, proteomics and immunoblotting demonstrated that LAI induced lipid metabolism enzym…

Supplementary Data Figures S1-S5 from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2023

Supplemental Figure S1: LAI remodels the lipidome of melanoma cells. Supplemental Figure S2: LAI induces UGCG, and UGCG inhibition augments DC661 cytotoxicity, and this effect is not seen by blocking cholesterol synthesis and key earlier s…

Data from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2023

Lysosomal autophagy inhibition (LAI) with hydroxychloroquine or DC661 can enhance cancer therapy, but tumor regrowth is common. To elucidate LAI resistance, proteomics and immunoblotting demonstrated that LAI induced lipid metabolism enzym…

Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition Open

Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown , et al. · 2022

Lysosomal autophagy inhibition (LAI) with hydroxychloroquine or DC661 can enhance cancer therapy, but tumor regrowth is common. To elucidate LAI resistance, proteomics and immunoblotting demonstrated that LAI induced lipid metabolism enzym…

Adhesion of <i>Crithidia fasciculata</i> promotes a rapid change in developmental fate driven by cAMP signaling Open

Shane Denecke, Madeline F. Malfara, Kelly R. Hodges, Nikki A. Holmes, Andre R. Williams , et al. · 2022

Kinetoplastids are single-celled parasites responsible for human and animal disease. For the vast majority of kinetoplastids, colonization of an insect host is required for transmission. Stable attachment to insect tissues via the single f…

cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory Open

David A. Christian, Thomas A. Adams, Lindsey A. Shallberg, Anthony T. Phan, Tony Smith , et al. · 2022

In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs) whose role in response to infection is poorly understood. After intraperitoneal immunization with Toxoplasma gondii , conventional type 1 dendritic cel…

Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography Open

Ana Ripolles-García, Gordon Ruthel, Gui‐Shuang Ying, Yineng Chen, Nicolás Cuenca , et al. · 2021

Purpose: To present a methodology for quantification of the canine retinal vasculature imaged by optical coherence tomography angiography (OCTA) and validate this approach by comparison with fluorescein angiography (FA) and confocal imagin…

WWOX-Mediated Degradation of AMOTp130 Negatively Affects Egress of Filovirus VP40 VLPs Open

Jingjing Liang, Gordon Ruthel, Bruce D. Freedman, Ronald N. Harty · 2021

Ebola (EBOV) and Marburg (MARV) viruses continue to emerge and cause severe hemorrhagic disease in humans. A comprehensive understanding of the filovirus-host interplay will be crucial for identifying and developing antiviral strategies. T…

C2CD6 is required for assembly of the CatSper calcium channel complex and fertilization Open

Fang Yang, Marıá Gracia Gervasi, N. Adrian Leu, Darya A. Tourzani, Gordon Ruthel , et al. · 2021

Summary The CatSper cation channel is essential for sperm capacitation and male fertility. The multi-subunit CatSper complexes form highly organized calcium signaling nanodomains on flagellar membranes. Here we report identification of an …

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells Open

Laura M. McLane, Shin Foong Ngiow, Zeyu Chen, John Attanasio, Sasikanth Manne , et al. · 2021

YTHDC2 Is Essential for Pachytene Progression and Prevents Aberrant Microtubule-Driven Telomere Clustering in Male Meiosis Open

Rong Liu, Seth D. Kasowitz, David Homolka, N. Adrian Leu, Jordan T. Shaked , et al. · 2021

SUMMARY Mechanisms driving the prolonged meiotic prophase I are poorly understood. The RNA helicase YTHDC2 is critical for mitosis to meiosis transition, as YTHDC2-deficient mouse germ cells initiate meiosis but arrest with mixed character…

Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress Open

Jingjing Liang, Gordon Ruthel, Cari A. Sagum, Mark T. Bedford, Sachdev S. Sidhu , et al. · 2021

Filoviruses (EBOV and MARV) and arenavirus (LASV) are zoonotic, emerging pathogens that cause outbreaks of severe hemorrhagic fever in humans. A fundamental understanding of the virus-host interface is critical for understanding the biolog…

Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress Open

Jingjing Liang, Gordon Ruthel, Cari A. Sagum, Mark T. Bedford, Sachdev S. Sidhu , et al. · 2021

Filoviridae family members Ebola (EBOV) and Marburg (MARV) viruses and Arenaviridae family member Lassa virus (LASV) are emerging pathogens that can cause hemorrhagic fever and high rates of mortality in humans. A better understanding of t…

YTHDC2 is Essential for Pachytene Progression and Prevents Aberrant Microtubule-Driven Telomere Clustering in Male Meiosis Open

Rong Liu, Seth D. Kasowitz, David Homolka, N. Adrian Leu, Jordan T. Shaked , et al. · 2021

cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory Open

David A. Christian, Thomas A. Adams, Tony Smith, Lindsey A. Shallberg, Derek J. Theisen , et al. · 2020

The omentum in the peritoneal cavity contains fat associated lymphoid clusters (FALCs) whose role in the response to microbial challenge are poorly understood. After intraperitoneal immunization with Toxoplasma gondii , type I dendritic ce…

Esophageal 3D organoids of <i>MPV17-/-</i> mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Open

Manti Guha, Satish Srinivasan, Maura M. Sheehan, Takashi Kijima, Gordon Ruthel , et al. · 2019

Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial genome (mtDNA) conten…

Safety and long-term efficacy of AAV2-BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies Open

Karina E Guziewicz, Artur V. Cideciyan, Brian Thomas Kendrick, Valérie Dufour, Gordon Ruthel , et al. · 2019

Correction to: HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression Open

Manti Guha, Satish Srinivasan, Kip E. Guja, Edison Mejía, Miguel Garcı́a-Dı́az , et al. · 2019

hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction Open

Manti Guha, Satish Srinivasan, F. Bradley Johnson, Gordon Ruthel, Kip E. Guja , et al. · 2018

Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage respon…

The single mitochondrion of the kinetoplastid parasite <i>Crithidia fasciculata</i> is a dynamic network Open

John DiMaio, Gordon Ruthel, Joshua J. Cannon, Madeline F. Malfara, Megan L. Povelones · 2018

Mitochondria are central organelles in cellular metabolism. Their structure is highly dynamic, allowing them to adapt to different energy requirements, to be partitioned during cell division, and to maintain functionality. Mitochondrial dy…

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments Open

Karina E Guziewicz, Artur V. Cideciyan, William A. Beltran, András M. Komáromy, Valérie Dufour , et al. · 2018

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence Open

Jie Xu, Yan Sun, Yize Li, Gordon Ruthel, Susan R. Weiss , et al. · 2017

Replication defective viral genomes (DVGs) generated during virus replication are the primary triggers of antiviral immunity in many RNA virus infections. However, DVGs can also facilitate viral persistence. Why and how these two opposing …

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence Open

Jie Xu, Yan Sun, Yize Li, Gordon Ruthel, Susan R. Weiss , et al. · 2017

Replication defective viral genomes (DVGs) generated during virus replication are the primary triggers of antiviral immunity in many RNA virus infections. However, DVGs can also facilitate viral persistence. Why and how these two opposing …

HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression Open

Manti Guha, Satish Srinivasan, Kip E. Guja, Edison Mejía, Miguel Garcı́a-Dı́az , et al. · 2016

Reduced mitochondrial DNA copy number, mitochondrial DNA mutations or disruption of electron transfer chain complexes induce mitochondria-to-nucleus retrograde signaling, which induces global change in nuclear gene expression ultimately co…

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