Gordon Wiegand
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View article: Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 87K, Bar graph depicting total number of differentially expressed genes, as well as relative numbers induced or repressed under various treatment conditions
View article: Supplementary Figure 4 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 4 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 363K, Ingenuity pathway analysis demonstrating two common networks targeted by mithramycin in lung cancer cells in vitro and in vivo
View article: Data from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Data from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
Cigarette smoking at diagnosis or during therapy correlates with poor outcome in patients with lung and esophageal cancers, yet the underlying mechanisms remain unknown. In this study, we observed that exposure of esophageal cancer cells t…
View article: Supplementary Figure 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 116K, qRT-PCR analysis of ABCG2 expression in untreated NSCLC and SCLC lines relative to SAEC, and in NSCLC and SCLC lines following CSC exposure
View article: Supplementary Figure 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 346K, Ingenuity pathway analysis depicting representative intracellular networks modulated by mithramycin lung cancer xenografts
View article: Supplementary Table 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Table 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 76K, TaqMan and ChIP Primers, and Antibodies
View article: Supplementary Figure 4 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 4 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 363K, Ingenuity pathway analysis demonstrating two common networks targeted by mithramycin in lung cancer cells in vitro and in vivo
View article: Supplementary Methods from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Methods from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 111K
View article: Supplementary Table 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Table 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 76K, TaqMan and ChIP Primers, and Antibodies
View article: Supplementary Methods from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Methods from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 111K
View article: Supplementary Table 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Table 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 52K, ABCG2 Expression in Side Populations (sp) and Non-side Populations (nsp) of A549 and Calu-6 Cells Cultured with or without CSC
View article: Supplementary Table 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Table 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 77K, Genes Simultaneously Modulated in Lung Cancer Cells in-vitro and in-vivo by Mithramycin
View article: Supplementary Table 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Table 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 52K, ABCG2 Expression in Side Populations (sp) and Non-side Populations (nsp) of A549 and Calu-6 Cells Cultured with or without CSC
View article: Supplementary Figure 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 346K, Ingenuity pathway analysis depicting representative intracellular networks modulated by mithramycin lung cancer xenografts
View article: Data from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Data from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
Cigarette smoking at diagnosis or during therapy correlates with poor outcome in patients with lung and esophageal cancers, yet the underlying mechanisms remain unknown. In this study, we observed that exposure of esophageal cancer cells t…
View article: Supplementary Figure 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 116K, qRT-PCR analysis of ABCG2 expression in untreated NSCLC and SCLC lines relative to SAEC, and in NSCLC and SCLC lines following CSC exposure
View article: Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 87K, Bar graph depicting total number of differentially expressed genes, as well as relative numbers induced or repressed under various treatment conditions
View article: Supplementary Table 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Supplementary Table 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells Open
PDF file - 77K, Genes Simultaneously Modulated in Lung Cancer Cells in-vitro and in-vivo by Mithramycin
View article: Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells
Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells Open
View article: Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin
Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin Open
Metformin and Sorafenib have enhanced anti-cancer effects. However, in contradistinction to reports on other types of CSC, Metformin is less effective against HCC-derived-CSC LRCC. Our results suggest that combining Metformin with Sorafeni…