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View article: Cardiac Magnetic Resonance Imaging vs Coronary Angiography as Primary Strategy in Newly Diagnosed Heart Failure
Cardiac Magnetic Resonance Imaging vs Coronary Angiography as Primary Strategy in Newly Diagnosed Heart Failure Open
Although CATH was superior for diagnosing ICM, CMR showed similar sensitivity and could significantly reduce CATH procedures without increasing the risk of missing critical coronary interventions. Longitudinal studies are needed to assess …
View article: Baseline characteristics of patients with acute ischaemic stroke included in the randomised controlled Find-AF 2 trial
Baseline characteristics of patients with acute ischaemic stroke included in the randomised controlled Find-AF 2 trial Open
Background In the Find-AF 2 randomised controlled trial, we investigate whether a risk-adapted intensified heart rhythm monitoring with subsequent initiation of oral anticoagulation in ischaemic stroke patients leads to a reduction of recu…
View article: The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis
The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis Open
Background and aims Endogenous Cushing's syndrome (CS) is characterized by an unfavorable cardiovascular (CV) and metabolic risk profile, but the potential adverse effects of hypercortisolism on myocardial function are not well known. Myoc…
View article: 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study
3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study Open
View article: Association between self-reported and objectively assessed physical functioning in the general population
Association between self-reported and objectively assessed physical functioning in the general population Open
View article: Prognostic Utility of Pericardial Effusion in the General Population: Findings From the STAAB Cohort Study
Prognostic Utility of Pericardial Effusion in the General Population: Findings From the STAAB Cohort Study Open
Background The incidental finding of a pericardial effusion (PE) poses a challenge in clinical care. PE is associated with malignant conditions or severe cardiac disease but may also be observed in healthy individuals. This study explored …
View article: Determinants and reference values of the 6-min walk distance in the general population—results of the population-based STAAB cohort study
Determinants and reference values of the 6-min walk distance in the general population—results of the population-based STAAB cohort study Open
Aims The 6-min walk test is an inexpensive, safe, and easy tool to assess functional capacity in patients with cardiopulmonary diseases including heart failure (HF). There is a lack of reference values, which are a prerequisite for the int…
View article: Population data–based federated machine learning improves automated echocardiographic quantification of cardiac structure and function: the <i>Automatisierte Vermessung der Echokardiographie</i> project
Population data–based federated machine learning improves automated echocardiographic quantification of cardiac structure and function: the <i>Automatisierte Vermessung der Echokardiographie</i> project Open
Aims Machine-learning (ML)-based automated measurement of echocardiography images emerges as an option to reduce observer variability. The objective of the study is to improve the accuracy of a pre-existing automated reading tool (‘origina…
View article: Heart rate–corrected systolic ejection time: population-based reference values and differential prognostic utility in acute heart failure
Heart rate–corrected systolic ejection time: population-based reference values and differential prognostic utility in acute heart failure Open
Aims Systolic ejection time (SET) is discussed as a treatment target in patients with heart failure (HF) and a reduced left ventricular (LV) ejection fraction (EF). We derived reference values for SET correcting for its dependence on heart…
View article: A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials
A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials Open
View article: Differential network interactions between psychosocial factors, mental health, and health-related quality of life in women and men
Differential network interactions between psychosocial factors, mental health, and health-related quality of life in women and men Open
View article: Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design
Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design Open
The Find-AF 2 trial aims to demonstrate that enhanced, prolonged and intensified rhythm monitoring results in a more effective prevention of recurrent ischemic stroke and systemic embolism compared to usual care.
View article: A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials
A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials Open
Purpose To investigate the trade-off between survival outcome and quality of life (QoL) in Multiple Myeloma (MM). Methods We developed a questionnaire that asked patients amongst others, whether they would choose a shortened time of progre…
View article: Deep phenotyping as a contribution to personalized depression therapy: the GEParD and DaCFail protocols
Deep phenotyping as a contribution to personalized depression therapy: the GEParD and DaCFail protocols Open
Depressive patients suffer from a complex of symptoms of varying intensity compromising their mood, emotions, self-concept, neurocognition, and somatic function. Due to a mosaic of aetiologies involved in developing depression, such as som…
View article: The Population Comparison Index: An Intuitive Measure to Calibrate the Extent of Impairments in Patient Cohorts in Relation to Healthy and Diseased Populations
The Population Comparison Index: An Intuitive Measure to Calibrate the Extent of Impairments in Patient Cohorts in Relation to Healthy and Diseased Populations Open
We assume that a specific health constraint, e.g., a certain aspect of bodily function or quality of life that is measured by a variable X, is absent (or irrelevant) in a healthy reference population (Ref0), and it is materially present an…
View article: The assessment of cognitive function in the German National Cohort (NAKO) – Associations of demographics and psychiatric symptoms with cognitive test performance
The assessment of cognitive function in the German National Cohort (NAKO) – Associations of demographics and psychiatric symptoms with cognitive test performance Open
To describe the cognitive test battery of the German National Cohort (NAKO), a population-based mega cohort of 205,000 randomly selected participants, and to examine associations with demographic variables and selected psychiatric and neur…
View article: Mild autonomous cortisol secretion portends similar cardiac compromise as overt endogenous Cushings syndrome
Mild autonomous cortisol secretion portends similar cardiac compromise as overt endogenous Cushings syndrome Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): German Ministry of Research and Education within the Comprehensive Heart Failure Centre Würzburg OnBehalf CV-CortEx Background Endogenous Cush…
View article: Endogenous Cushings syndrome is associated with impaired myocardial work efficiency
Endogenous Cushings syndrome is associated with impaired myocardial work efficiency Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): German Ministry of Research and Education within the Comprehensive Heart Failure Center, Würzburg OnBehalf STAAB Cohort Study…
View article: DIPS (Dystonia Image-based Programming of Stimulation: a prospective, randomized, double-blind crossover trial)
DIPS (Dystonia Image-based Programming of Stimulation: a prospective, randomized, double-blind crossover trial) Open
Introduction Deep brain stimulation of the internal globus pallidus is an effective treatment for dystonia. However, there is a large variability in clinical outcome with up to 25% non-responders even in highly selected primary dystonia pa…
View article: Seroprävalenz von COVID-19 und psychosoziale Auswirkungen in der Allgemeinbevölkerung: Ergebnisse des STAAB-COVID-One Programms
Seroprävalenz von COVID-19 und psychosoziale Auswirkungen in der Allgemeinbevölkerung: Ergebnisse des STAAB-COVID-One Programms Open
Zusammenfassung Ziel der Studie Die aktuelle SARS-CoV-2 Forschung fokussiert sich bisher weitgehend auf symptomatische Fälle. Die STAAB-COVID-Studie untersuchte daher die Seroprävalenz von COVID-19 in der Allgemeinbevölkerung und die psych…
View article: Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)
Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP) Open
View article: Functional versus morphological assessment of vascular age in patients with coronary heart disease
Functional versus morphological assessment of vascular age in patients with coronary heart disease Open
View article: Left Ventricular Remodeling and Myocardial Work: Results From the Population-Based STAAB Cohort Study
Left Ventricular Remodeling and Myocardial Work: Results From the Population-Based STAAB Cohort Study Open
Introduction: Left ventricular (LV) dilatation and LV hypertrophy are acknowledged precursors of myocardial dysfunction and ultimately of heart failure, but the implications of abnormal LV geometry on myocardial function are not well-under…
View article: Impact of cardiovascular risk factors on myocardial work—insights from the STAAB cohort study
Impact of cardiovascular risk factors on myocardial work—insights from the STAAB cohort study Open
View article: Musical Intervals in Infants’ Spontaneous Crying over the First 4 Months of Life
Musical Intervals in Infants’ Spontaneous Crying over the First 4 Months of Life Open
Introduction: Perception and memorizing of melody and rhythm start about the third trimester of gestation. Infants have astonishing musical predispositions, and melody contour is most salient for them. Objective:
View article: Myocardial work - correlation patterns and reference values from the population-based STAAB cohort study
Myocardial work - correlation patterns and reference values from the population-based STAAB cohort study Open
Derived from a large sample of apparently healthy individuals from a population based-cohort, we provide age-adjusted reference values for myocardial work indices, applicable for either sex. Weak correlations with common echocardiographic …
View article: Prevalence and determinants of the precursor stages of heart failure: results from the population-based STAAB cohort study
Prevalence and determinants of the precursor stages of heart failure: results from the population-based STAAB cohort study Open
Aims Prevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population. Methods and Results …
View article: Consumption of <i>Lactobacillus reuteri</i>‐containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial
Consumption of <i>Lactobacillus reuteri</i>‐containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial Open
Background The objective of this trial was to evaluate whether the regular consumption of probiotics may improve the known deterioration of periodontal health in navy sailors during deployments at sea. Methods 72 healthy sailors of a naval…
View article: Brain Natriuretic Peptide and Discovery of Atrial Fibrillation After Stroke
Brain Natriuretic Peptide and Discovery of Atrial Fibrillation After Stroke Open
Background and Purpose— Diagnosing paroxysmal atrial fibrillation (pAF) can be challenging after acute ischemic stroke. Enhanced and prolonged Holter-ECG monitoring (EPM) improves the detection rate but is not feasible for all patients. We…
View article: Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study Open
The female myocardium appeared more vulnerable to high blood pressure and dyslipidemia when compared to men, while obesity was associated with adverse myocardial deformation in either sex. The reference values for echocardiographic myocard…