Nancy R. Gough
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View article: Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth
Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth Open
The worldwide frequency of head and neck squamous cell carcinoma (HNSCC) is approximately 800,000 new cases, with 430,000 deaths annually. We determined that LZK (encoded by MAP3K13 ) is a therapeutic target in HNSCC and showed that inhibi…
Supplementary Figures and legends from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Supplementary Figures and legends
Supplementary Table 1 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Upregulated or downregulated genes by PJA1 knockdown and TGF-β1 streatment in HepG2 cells
Supplementary Materials and Methods-PJA1-Cancer research from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Supplementary Materials and Methods
Supplementary Materials and Methods-PJA1-Cancer research from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Supplementary Materials and Methods
Supplementary Table 4 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Characteristics of HCC patients with PJA1 genetic alterations
Supplementary Table 3 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Gene numbers regulated by PJA1 knockdown and TGF-β1 treatment
Supplementary Table 2 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Upregulated or downregulated genes in samples expressing a high level of PJA1
Supplementary Figures and legends from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Supplementary Figures and legends
Supplementary Table 4 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Characteristics of HCC patients with PJA1 genetic alterations
Supplementary Table 3 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Gene numbers regulated by PJA1 knockdown and TGF-β1 treatment
Data from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in TGFβ/SMAD signaling. SMAD3 and its adaptors, such as β2SP, are important mediators of…
Supplementary Table 2 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Upregulated or downregulated genes in samples expressing a high level of PJA1
Data from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in TGFβ/SMAD signaling. SMAD3 and its adaptors, such as β2SP, are important mediators of…
Supplementary Table 1 from Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
Upregulated or downregulated genes by PJA1 knockdown and TGF-β1 streatment in HepG2 cells
Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer Open
Hepatocellular carcinoma (HCC) is the primary form of liver cancer and a major cause of cancer death worldwide. Early detection is key to effective treatment. Yet, early diagnosis is challenging, especially in patients with cirrhosis, who …
Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling Open
RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in TGFβ/SMAD signaling. SMAD3 and its adaptors, such as β2SP, are important mediators of…
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer Open
Clinical and preclinical studies show tissue-specific differences in tumorigenesis. Tissue specificity is controlled by differential gene expression. We prioritized genes that encode secreted proteins according to their preferential expres…
Focus Issue: Cell biology meets cancer therapy Open
Newly discovered druggable targets and mechanisms of action for available drugs reveal new ways to kill cancer cells and personalize therapy.