Gourab Basu Choudhury
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View article: Structure-guided discovery and characterization of novel FLT3 inhibitors for acute myeloid leukemia treatment
Structure-guided discovery and characterization of novel FLT3 inhibitors for acute myeloid leukemia treatment Open
FLT3 (FMS-like tyrosine kinase 3), a receptor tyrosine kinase, is frequently mutated in acute myeloid leukemia (AML), a hematologic malignancy marked by aggressive proliferation, poor prognosis, and high relapse rates. Although FDA-approve…
View article: Structure-Guided Discovery and Characterization of Novel FLT3 Inhibitors for Acute Myeloid Leukemia Treatment
Structure-Guided Discovery and Characterization of Novel FLT3 Inhibitors for Acute Myeloid Leukemia Treatment Open
FLT3 (FMS-like tyrosine kinase 3), a receptor tyrosine kinase, is frequently mutated in acute myeloid leukemia (AML), a hematologic malignancy marked by aggressive proliferation, poor prognosis, and high relapse rates. Although FDA-approve…
View article: Identification of critical amino acids in the DNA binding domain of LuxO: Lessons from a constitutive active LuxO
Identification of critical amino acids in the DNA binding domain of LuxO: Lessons from a constitutive active LuxO Open
Quorum sensing plays a vital role in the environmental and host life cycles of Vibrio cholerae . The quorum-sensing circuit involves the consorted action of autoinducers, small RNAs, and regulatory proteins to control a plethora of physiol…
View article: Implication of structural constrains facilitating the functional evolution of<i>Pseudomonas aeruginosa</i>KPR2 into a versatile α-keto acid reductase
Implication of structural constrains facilitating the functional evolution of<i>Pseudomonas aeruginosa</i>KPR2 into a versatile α-keto acid reductase Open
Protein structure and function dynamics in molecular evolution are intertwined. Theoretical concepts linking structure, function, and evolution of a protein, while often intuitive, necessitate validation through investigations in real-worl…