Grace Ariani
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View article: Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions
Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions Open
Background: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality, yet its pathophysiology is not fully understood. Recent studies suggest that dysregulated maternal immune responses, particularly involving…
View article: Diagnostic ultrasound to inform the surgical approach to cesarean delivery in patients at high risk for placenta accreta spectrum disorders
Diagnostic ultrasound to inform the surgical approach to cesarean delivery in patients at high risk for placenta accreta spectrum disorders Open
Comprehensive preoperative ultrasound can reasonably predict the appropriate surgical approach to placenta accreta spectrum. This can be achieved by assessing intracervical hypervascularity and urinary bladder wall distortion using a combi…
View article: Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions
Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions Open
Background: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality, yet its pathophysiology is not fully understood. Recent studies suggest that dysregulated maternal immune responses, particularly involving…
View article: AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma
AEG‑1 expression analysis in epithelial ovarian carcinoma: Uncovering distinctions between high‑grade and low‑grade serous carcinoma Open
Epithelial ovarian carcinoma (EOC) is the most common form of ovarian cancer and is associated with a poor prognosis. Astrocyte Elevated Gene-1 (AEG-1) is an oncogene implicated in cancer cell growth and progression. The present study exam…
View article: Clinicopathological Profile of Laryngeal Carcinoma at Dr Soetomo General Academic Hospital, Surabaya 2018-2021
Clinicopathological Profile of Laryngeal Carcinoma at Dr Soetomo General Academic Hospital, Surabaya 2018-2021 Open
Introduction Laryngeal carcinoma is the second most common malignancy of the respiratory tract1. Based on 2020 Global Cancer Observatory data, the incidence rate of laryngeal carcinoma is 184,615 cases with a mortality rate > 50%2. There a…
View article: Comparison of PD-L1, CTR-1, VEGF, and p53 expression in sensitive and resistant epithelial ovarian cancer (EOC) patients to platinum-based chemotherapy
Comparison of PD-L1, CTR-1, VEGF, and p53 expression in sensitive and resistant epithelial ovarian cancer (EOC) patients to platinum-based chemotherapy Open
The current standard treatment for ovarian cancer is a combination of cytoreductive surgery and platinum-based chemotherapy; however, many patients develop resistance, leading to a high recurrence rate. The aim of this study was to analyze…
View article: Profile of Somatic BRCA1/2 Mutations in High Grade Serous Ovarian Carcinoma
Profile of Somatic BRCA1/2 Mutations in High Grade Serous Ovarian Carcinoma Open
Ovarian cancer ranks as the third most prevalent cancer among women, with 70% of these cases classified as high-grade serous ovarian carcinoma (HGSOC). This type is marked by significant genomic instability and the presence of somatic loss…
View article: Assess the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: performance evaluation study (Preprint)
Assess the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: performance evaluation study (Preprint) Open
BACKGROUND Interpreting histopathology slides and scientific figures requires specialized skills and knowledge. Pathologists analyze various tissues and cells, while the general population often struggles with the technical information in…
View article: The Relationship Between Expression of HIF-1α and Clinical Response in Cervical Cancer Patients with Neoadjuvant Chemotherapy at Dr. Soetomo Surabaya Hospital
The Relationship Between Expression of HIF-1α and Clinical Response in Cervical Cancer Patients with Neoadjuvant Chemotherapy at Dr. Soetomo Surabaya Hospital Open
This investigation aims to analyze the relationship between expression of Hypoxia Inducible factors-1 αlfa (HIF-1α) to assess the response to neoadjuvant chemotherapy in cervical cancer patients. This research is a Quast Experimental Non-R…
View article: Vesicouterine adherence is independent of the degree of villi implantation: A retrospective case-control study
Vesicouterine adherence is independent of the degree of villi implantation: A retrospective case-control study Open
Background: The presence of differences between the clinical and histological classification of PAS hinders an accurate depiction of the extent of the maternal condition. None of the existing histological classification criteria are based …
View article: Profile of Placenta Accreta Spectrum in Dr. Soetomo General Hospital Between 2017-2021
Profile of Placenta Accreta Spectrum in Dr. Soetomo General Hospital Between 2017-2021 Open
Background: Placenta accreta spectrum is the cause of profuse bleeding and is hard to control during operation. In this study, during the period 2017 – 2021, 431 cases of placenta were obtained based on the number of patients treated at Dr…
View article: Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection
Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection Open
The presence of SARS-CoV-2 spike protein as well as altered inflammatory and apoptotic processes may indicate the presence of placental disturbance in third-trimester maternal COVID-19 infection. The lack of correlation between placental d…
View article: Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19
Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Open
Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. …
View article: Transabdominal and transvaginal ultrasound findings help to guide the clinical management of placenta accreta spectrum cases
Transabdominal and transvaginal ultrasound findings help to guide the clinical management of placenta accreta spectrum cases Open
Introduction The clinical management of placenta accreta spectrum (PAS) depends on placental topography and vascular involvement. Our aim was to determine whether transabdominal and transvaginal ultrasound signs can predict PAS management.…
View article: BRCA 1 and 2 somatic mutation in high grade serous epithelial ovarian cancer in Indonesian women that was operated on Dr. Soetomo General Hospital, Surabaya in 2019-2021
BRCA 1 and 2 somatic mutation in high grade serous epithelial ovarian cancer in Indonesian women that was operated on Dr. Soetomo General Hospital, Surabaya in 2019-2021 Open
Link of Video Abstract: https://youtu.be/9kem7M9SNWIBackground: Ovarian cancer remains as major problem worldwide. BRCA1 and BRCA2 play a unique role in deoxyribonucleic acid (DNA) damage repair, especially in homologous recombination repa…
View article: Placenta accreta spectrum with severe morbidity: fibrosis associated with cervical-trigonal invasion
Placenta accreta spectrum with severe morbidity: fibrosis associated with cervical-trigonal invasion Open
PAS in the cervical trigonal area associated with fibrosis implies a greater risk of complications due to uncontrollable bleeding and organ damage. MSTH is associated with lower morbidity and difficulties in PAS type 4. Prenatal or intrasu…
View article: Placental apoptotic index on COVID-19 and non-COVID-19 cases: a cross sectional study
Placental apoptotic index on COVID-19 and non-COVID-19 cases: a cross sectional study Open
Backgrounds: Rare cases of COVID-19 vertical transmission are reported, even though abnormal findings on placenta histopathology are frequently reported on SARS-CoV-2 infected pregnancies. However, no publications report the impact of COVI…
View article: The correlation between serum levels and placental tissue expression of PLGF and sFLT-1 and the FIGO grading of the placenta accreta spectrum disorders
The correlation between serum levels and placental tissue expression of PLGF and sFLT-1 and the FIGO grading of the placenta accreta spectrum disorders Open
There are differences in PAS's angiogenic processes according to the severity of trophoblast cell invasion. But there is no overall correlation between serum levels and PLGF and sFlt-1 expression in the placenta, suggesting the imbalance …
View article: Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19
Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19 Open
\nBackground: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: T…
View article: Placenta accreta spectrum with severe morbidity: fibrosis associated with cervical-trigonal invasion
Placenta accreta spectrum with severe morbidity: fibrosis associated with cervical-trigonal invasion Open
Describe the clinical-surgical results of patients with PAS in the low-posterior cervical-trigonal space associated with fibrosis (PAS type 4) compared with PAS types in other locations (Types 1, upper bladder, 2 in upper parametrium) and …
View article: Uterine conservative–resective surgery for selected placenta accreta spectrum cases: Surgical–vascular control methods
Uterine conservative–resective surgery for selected placenta accreta spectrum cases: Surgical–vascular control methods Open
Introduction The incidence of placenta accreta spectrum (PAS) has increased, but the optimal management and the optimal way to achieve vascular control are still controversial. This study aims to compare maternal outcomes between different…
View article: Vascular Endothelial Growth Factor (VEGF) Expression on Placenta Accreta Spectrum (PAS) FIGO Grading
Vascular Endothelial Growth Factor (VEGF) Expression on Placenta Accreta Spectrum (PAS) FIGO Grading Open
This study aims to analyze the role of placenta VEGF level using immunocytochemical techniques andcomparing the obtained results with PAS FIGO grading. This retrospective cross sectional study ontotal sampling of formalin fixed paraffin-em…
View article: The Role of IFN gamma and IL-10 in Breast Cancer
The Role of IFN gamma and IL-10 in Breast Cancer Open
Inflammation in the tumor microenvironmentisanessentialaspectof tumor biologicalactivity.Interferon γ and IL-10 are pro-inflammatoryand anti-inflammatorycytokinesthatplay a crucialrole in regulatingthehost'simmuneresponseto cancer cells.IF…