Grace A. Arya
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View article: Efficient amplicon panels for evaluating hybridization and genetic structure in the <i>Schistosoma haematobium</i> species group
Efficient amplicon panels for evaluating hybridization and genetic structure in the <i>Schistosoma haematobium</i> species group Open
Genetic markers for detecting hybridization and measuring population genetic parameters must be informative and cost-effective. Most population genetic studies within the Schistosoma haematobium species group rely on either a two-marker sy…
View article: Impact of intensive control on malaria population genomics in Eastern Myanmar
Impact of intensive control on malaria population genomics in Eastern Myanmar Open
The malaria elimination program in Kayin State (Myanmar) utilizes malaria posts for rapid detection and treatment together with mass drug administration (MDA) in high transmission villages, and has reduced transmission by 97%. We examined …
View article: Malaria parasite population genomics during an elimination program in Eastern Myanmar
Malaria parasite population genomics during an elimination program in Eastern Myanmar Open
Summary Background We investigated parasite population genomics during an intensive malaria elimination program in Kayin State (Myanmar), in which malaria posts were used for rapid detection and treatment of malaria cases, while mass drug …
View article: Genomic data reveal a north-south split and introgression history of blood fluke (<i>Schistosoma haematobium</i>) populations from across Africa
Genomic data reveal a north-south split and introgression history of blood fluke (<i>Schistosoma haematobium</i>) populations from across Africa Open
The human parasitic fluke, Schistosoma haematobium hybridizes with the livestock parasite S. bovis in the laboratory, but the frequency of hybridization in nature is unclear. We analyzed 34.6 million single nucleotide variants in 162 sampl…
View article: Nutrient Limitation Magnifies Fitness Costs of Antimalarial Drug Resistance Mutations
Nutrient Limitation Magnifies Fitness Costs of Antimalarial Drug Resistance Mutations Open
Drug resistance mutations tend to disrupt key physiological processes and frequently carry fitness costs, which are a central determinant of the rate of spread of these mutations in natural populations. Head-to-head competition assays prov…
View article: Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations
Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations Open
Summary Drug resistance mutations tend to disrupt key physiological processes, and therefore carry a fitness cost. The size of these fitness costs is a central determinant of the rate of spread of these mutations in natural populations so …
View article: Fitness Costs and the Rapid Spread of <i>kelch13</i> -C580Y Substitutions Conferring Artemisinin Resistance
Fitness Costs and the Rapid Spread of <i>kelch13</i> -C580Y Substitutions Conferring Artemisinin Resistance Open
Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in South…