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View article: Localizing Objective versus Subjective Cognition in Preclinical Alzheimer's Disease Using Atrophy Network Mapping
Localizing Objective versus Subjective Cognition in Preclinical Alzheimer's Disease Using Atrophy Network Mapping Open
Background Alzheimer's disease (AD) pathologic changes, such as amyloid‐β (Aβ) accumulation, begin years before cognitive and functional impairment. However, it remains unclear if Aβ‐associated brain atrophy at this preclinical stage of AD…
View article: Using Cerebrospinal Fluid Improves Detection of Individual Brain Atrophy
Using Cerebrospinal Fluid Improves Detection of Individual Brain Atrophy Open
Background Clinical neuroradiologists routinely look for expansion of CSF spaces to help identify atrophy on patient MRI scans. In contrast, automated methods for identifying atrophy rely on changes in grey matter volume or cortical thickn…
View article: Localization of Network-Level Atrophy in Preclinical Alzheimer's Disease
Localization of Network-Level Atrophy in Preclinical Alzheimer's Disease Open
Brain atrophy may precede symptoms in Alzheimer's disease (AD), but it remains unclear whether atrophy in this preclinical stage falls within a distinct brain network or is associated with transitional cognitive changes. We investigated co…