Gang Zheng
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View article: The Associations of General, Central, Visceral Obesity, and Body Fat Percentage with Cognitive Impairment in the Elderly: Meta-analysis and Mendelian Randomization Study
The Associations of General, Central, Visceral Obesity, and Body Fat Percentage with Cognitive Impairment in the Elderly: Meta-analysis and Mendelian Randomization Study Open
It is unclear whether various obesity phenotypes are differently associated with cognitive disorders. The aim of this study was to examine the associations of general obesity [measured by body mass index (BMI)], central obesity [measured b…
View article: Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis
Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis Open
Intranasal corticosteroid combined with mucoactive drugs therapy (budesonide-256 μg/day combined with ELP enteric capsules-0.8 g/day) has the potential to improve subjective symptoms and promote physiological recovery for adult patients wi…
View article: Research and Application of Anti-Wear and Wax Prevention Technologies for Horizontal Wells in Qingcheng Shale Oil
Research and Application of Anti-Wear and Wax Prevention Technologies for Horizontal Wells in Qingcheng Shale Oil Open
Shale oil development employs large platforms, multi-layer systems, and horizontal wells in a three-dimensional approach. The complexity of horizontal shale oil well environments is influenced by factors such as development models, fluid c…
View article: Metagenomics-assembled genomes reveal microbial metabolic adaptation to athalassohaline environment, the case Lake Barkol, China
Metagenomics-assembled genomes reveal microbial metabolic adaptation to athalassohaline environment, the case Lake Barkol, China Open
Salt-tolerant and halophilic microorganisms are critical drivers of ecosystem stability and biogeochemical cycling in athalassohaline environments. Lake Barkol, a high-altitude inland saline lake, provides a valuable natural setting for in…
View article: The role of intracellular and extracellular copper compartmentalization in Alzheimer’s disease pathology and its implications for diagnosis and therapy
The role of intracellular and extracellular copper compartmentalization in Alzheimer’s disease pathology and its implications for diagnosis and therapy Open
Copper is a trace element indispensable for cellular physiology, integral to cellular redox balance, and a constituent of enzyme active sites, thereby playing a pivotal role in cellular physiological function. Concerning the pathogenesis o…
View article: Mitofilin–mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits
Mitofilin–mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits Open
Neurotoxic damage resulting from lead pollution exposure constitutes a significant public health concern. The regulatory impact of lead (Pb) exposure on neuronal dendritic spine plasticity, a crucial mechanism for neuronal adaptation, warr…
View article: Descriptive report of complex cystic renal mass fluid cytology: a cross-sectional analysis
Descriptive report of complex cystic renal mass fluid cytology: a cross-sectional analysis Open
Based on routine cytologic analysis, there is no clear pattern with the presence or absence of malignant cells in the fluid of complex renal cysts. More sophisticated testing may provide insight into the malignant potential of renal cyst f…
View article: Two-Dimensional MXenes Surface Engineering Nanoplatform for PTT-Chemotherapy Synergistic Tumor Therapy
Two-Dimensional MXenes Surface Engineering Nanoplatform for PTT-Chemotherapy Synergistic Tumor Therapy Open
This study provides a new strategy for developing MXene-based composite nano drug delivery systems to effectively combat TNBC.
View article: Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage
Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage Open
Neural repair within the lesion cavity caused by intracerebral hemorrhage (ICH) remains a major therapeutic challenge. Hydrogels hold great potential in regenerative medicine as functional scaffolds. However, inadequate host cell infiltrat…
View article: Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease
Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease Open
Importance Patients with juvenile idiopathic arthritis (JIA) may develop adult rheumatic diseases later in life, and prolonged or recurrent disease activity is often associated with substantial disability; therefore, it is important to ide…
View article: Variations of rumen metagenome and metabolome in dairy cows with different feed intake levels during the postpartum period
Variations of rumen metagenome and metabolome in dairy cows with different feed intake levels during the postpartum period Open
Feed intake, a critical factor for dairy cows during the postpartum period, is intricately linked to the rumen microbiome. However, the specific roles of rumen metagenome and metabolome in modulating feed intake in postpartum dairy cows re…
View article: Associations of clinical parameter‐based accelerated aging, genetic predisposition with risk of chronic kidney disease and associated life expectancy: A prospective cohort study
Associations of clinical parameter‐based accelerated aging, genetic predisposition with risk of chronic kidney disease and associated life expectancy: A prospective cohort study Open
Little evidence exists regarding the associations between clinical parameter‐based biological aging and the incidence and outcome of chronic kidney disease (CKD). Thus, we aimed to assess the associations between biological aging, genetic …
View article: Rolling-Translated circRUNX2.2 Promotes Lymphoma Cell Proliferation and Cycle Transition in Marek’s Disease Model
Rolling-Translated circRUNX2.2 Promotes Lymphoma Cell Proliferation and Cycle Transition in Marek’s Disease Model Open
Marek’s disease (MD), an immunosuppressive disease induced by the Marek’s disease virus (MDV), is regarded as an ideal model for lymphoma research to elucidate oncogenic and anti-oncogene genes. Using this model, we found that circRUNX2.2,…
View article: Strategies for overcoming the lung surfactant barrier and achieving success in antimicrobial photodynamic therapy
Strategies for overcoming the lung surfactant barrier and achieving success in antimicrobial photodynamic therapy Open
The impressive increase in antimicrobial resistance has required the development of alternative treatments that act on multiple non-specific molecular targets and are effective against a broad range of microorganisms. Antimicrobial Photody…
View article: Plant-based diet indices and their interaction with ambient air pollution on the ovarian cancer survival: A prospective cohort study
Plant-based diet indices and their interaction with ambient air pollution on the ovarian cancer survival: A prospective cohort study Open
Joint exposure to various ambient air pollutants was significantly associated with lower survival among patients with OC, particularly for those who predominantly consumed unhealthy plant-based foods.
View article: circRUNX2.2, highly expressed in Marek's disease tumor tissues, functions in cis to regulate parental gene RUNX2 expression
circRUNX2.2, highly expressed in Marek's disease tumor tissues, functions in cis to regulate parental gene RUNX2 expression Open
Marek's disease (MD), an immunosuppression disease induced by Marek's disease virus (MDV), is one of the significant diseases affecting the health and productive performance of poultry. The roles of circular RNAs (circRNAs) in MD developme…
View article: Rapid growth of acquired UBA1 mutations predisposes male patients to low-risk MDS
Rapid growth of acquired UBA1 mutations predisposes male patients to low-risk MDS Open
VEXAS (vacuoles, E1-ubiquitin-like modifier activating enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently described autoinflammatory disorder caused by acquired UBA1 mutations in hematopoietic precursor cells. The prevalen…
View article: Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance
Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance Open
Hainan yellow cattle are indigenous Zebu cattle from southern China known for their tolerance of heat and strong resistance to disease. Generations of adaptation to the tropical environment of southern China and decades of artificial breed…
View article: Exploring the Rumen Microbiota and Serum Metabolite Profile of Hainan Black Goats with Different Body Weights before Weaning
Exploring the Rumen Microbiota and Serum Metabolite Profile of Hainan Black Goats with Different Body Weights before Weaning Open
The critical role of the rumen microbiota in the growth performance of livestock is recognized, yet its significance in determining the body weight of goat kids before weaning remains less understood. To bridge this gap, our study delved i…
View article: Effective removal of enteric viruses by Moringa oleifera seed extract functionalized cotton filter
Effective removal of enteric viruses by Moringa oleifera seed extract functionalized cotton filter Open
Accessible and low-cost point-of-use technologies have significant potential to mitigate risk to public health, particularly in areas with limited resources and in disaster scenarios. Natural cotton fibers functionalized with water-soluble…
View article: An Unexpected Diagnosis Uncovered by Quantitative Molecular Findings: A Case Report
An Unexpected Diagnosis Uncovered by Quantitative Molecular Findings: A Case Report Open
A 74-year-old male presented with rectal pain; workup uncovered an anal mass, and a diagnosis of melanoma was rendered via histologic examination and immunohistochemical (IHC) studies. Droplet digital PCR (ddPCR)–based BRAF testing was per…
View article: Lineage switch of B‐acute lymphoblastic leukemia with t(11;19)(q23;p13.3) into acute myeloid leukemia with monocytic differentiation after induction chemotherapy
Lineage switch of B‐acute lymphoblastic leukemia with t(11;19)(q23;p13.3) into acute myeloid leukemia with monocytic differentiation after induction chemotherapy Open
A 65-year old woman with dyspnea, headaches, and epistaxis presented with anemia (hemoglobin 7.7 g/dL) and thrombocytopenia (platelets 18×109/L) with a white blood cell (WBC) count of 4.0 × 109/L and 60% circulating blasts. Bone marrow bla…
View article: Bibliometric analysis of worldwide research trends on breast cancer about inflammation
Bibliometric analysis of worldwide research trends on breast cancer about inflammation Open
Background The most prevalent cancer and the second-leading cause of cancer-related mortality in women is breast cancer. Growing interest has been shown in recent years in learning more about the processes behind the development of breast …
View article: PM2.5 exposure and its interaction of oxidative balance score on ovarian cancer survival: A prospective cohort study
PM2.5 exposure and its interaction of oxidative balance score on ovarian cancer survival: A prospective cohort study Open
Recent evidence advises particles with a diameter of 2.5 µm or less (PM2.5) might be a prognostic factor for ovarian cancer (OC) survival. The oxidative balance score (OBS) incorporates diet-lifestyle factors to estimate individuals' anti-…
View article: Table S4 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics
Table S4 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics Open
Supplementary Table S4