Grace Kaguthi
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View article: Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with <i>Plasmodium falciparum</i> Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study
Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with <i>Plasmodium falciparum</i> Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study Open
The novel antimalarial ganaplacide combined with lumefantrine solid dispersion formulation (LUM‐SDF) was effective and well tolerated in the treatment of uncomplicated falciparum malaria in adults, adolescents, and children in a multinatio…
View article: Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction
Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction Open
Importance Elevated serum uric acid (SUA) level may contribute to endothelial dysfunction; therefore, SUA is an attractive target for heart failure with preserved ejection fraction (HFpEF). However, to the authors’ knowledge, no prior rand…
View article: Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in Western Kenya
Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in Western Kenya Open
We observed high NTM prevalence rates with species-specific associations with TST induration, consistent with a model of species-dependent heterologous immunity among mycobacteria.
View article: Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria
Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria Open
Background The contribution of artefenomel to the clinical and parasiticidal activity of ferroquine and artefenomel in combination in uncomplicated Plasmodium falciparum malaria was investigated. Methods This Phase 2a, randomized, open-lab…
View article: A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria Open
View article: New Tuberculosis Vaccine Trials in Infants: design, diagnostics and trial site development
New Tuberculosis Vaccine Trials in Infants: design, diagnostics and trial site development Open
Tuberculosis is a major public health problem, with particularly high morbidity and mortality among infants. The only licensed TB vaccine, BCG confers only partial protection against pulmonary disease, the most common and most transmissibl…
View article: Development of a TB vaccine trial site in Africa and lessons from the Ebola experience
Development of a TB vaccine trial site in Africa and lessons from the Ebola experience Open
View article: Development of a TB vaccine trial site in Africa and lessons from the Ebola experience.
Development of a TB vaccine trial site in Africa and lessons from the Ebola experience. Open
Tuberculosis is the deadliest infection of our time. In contrast, about 11,000 people died of Ebola between 2014 and 2016. Despite this manifest difference in mortality, there is now a vaccine licensed in the United States and by the Europ…
View article: The impact of the nurses’, doctors’ and clinical officer strikes on mortality in four health facilities in Kenya
The impact of the nurses’, doctors’ and clinical officer strikes on mortality in four health facilities in Kenya Open
View article: Development of a TB vaccine trial site in Africa and lessons from the Ebola experience.
Development of a TB vaccine trial site in Africa and lessons from the Ebola experience. Open
Tuberculosis is the deadliest infection of our time. In contrast, about 11,000 people died of Ebola between 2014 and 2016. Despite this manifest difference in mortality, there is now a vaccine licensed in the United States and by the Europ…
View article: Development from a TB Vaccine Trial Site in Africa and Lessons from the Ebola Experience
Development from a TB Vaccine Trial Site in Africa and Lessons from the Ebola Experience Open
View article: The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya Open
There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colo…
View article: Predictors of post neonatal mortality in Western Kenya: a cohort study
Predictors of post neonatal mortality in Western Kenya: a cohort study Open
infant mortality was high and was associated with being born outside a health facility, maternal HIV infection and HIV infection of the infant. Measures to decrease mother to child transmission and other HIV control measures need to be str…