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View article: Author Response: Bias-aware Oxygen Saturation Index in Critical Care: A Standards-first Framework to Make a Useful Tool Truly Fair
Author Response: Bias-aware Oxygen Saturation Index in Critical Care: A Standards-first Framework to Make a Useful Tool Truly Fair Open
View article: Soft-tissue Imaging Modalities and Their Clinical Relevance in Rhino-orbital-cerebral Mucormycosis
Soft-tissue Imaging Modalities and Their Clinical Relevance in Rhino-orbital-cerebral Mucormycosis Open
Introduction: Rhino-orbital-cerebral mucormycosis (ROCM) is an invasive fungal infection that has experienced a surge in cases during the COVID-19. Imaging plays a crucial role in assessing the extent of the disease and guiding surgical ma…
View article: Diagnostic performance of GeneXpert MTB/RIF assay compared to conventional methods and its clinical correlation in tuberculosis management: A retrospective study from Puducherry, South India
Diagnostic performance of GeneXpert MTB/RIF assay compared to conventional methods and its clinical correlation in tuberculosis management: A retrospective study from Puducherry, South India Open
Background: Wide variations in tuberculosis prevalence and drug resistance necessitate region-specific data-based protocols for accurate diagnosis and management. This study aimed to compare the diagnostic performance of three diagnostic m…
View article: Exceptionally High Cystic Fibrosis-Related Morbidity and Mortality in Infants and Young Children in India: The Need for Newborn Screening and CF-Specific Capacity Building
Exceptionally High Cystic Fibrosis-Related Morbidity and Mortality in Infants and Young Children in India: The Need for Newborn Screening and CF-Specific Capacity Building Open
Early diagnosis of cystic fibrosis (CF) through newborn screening (NBS) improves clinical outcomes, but in countries like India, delayed diagnosis increases morbidity, mortality, and likely underestimates infant deaths from CF. We performe…
View article: Follow-up of phenotype and metabolic changes in adult males living with HIV on combination antiretroviral therapy (CART) for a decade
Follow-up of phenotype and metabolic changes in adult males living with HIV on combination antiretroviral therapy (CART) for a decade Open
Combination Antiretroviral Therapy (CART) is the mainstay in the treatment of HIV infection. However, long-term CART causes fat redistribution, insulin resistance, and dyslipidaemia in patients living with HIV (PLWH). There is limited data…
View article: Knowledge and Perception about Adolescent Onset Eating Disorders among Youth and Healthcare Professionals in India
Knowledge and Perception about Adolescent Onset Eating Disorders among Youth and Healthcare Professionals in India Open
Background: Eating disorders (EDs) are severe psychiatric diseases with high mortality and morbidity. This study aims to access awareness about ED among Indian youth and healthcare professionals (HCPs) and develop an assessment tool for th…
View article: Ultrasound Versus Fluoroscopy for Catheter Tip Confirmation in Long-Term Vascular Access: A Prospective Observational Study
Ultrasound Versus Fluoroscopy for Catheter Tip Confirmation in Long-Term Vascular Access: A Prospective Observational Study Open
Ultrasonographic confirmation of the vascular catheter tip position is a quick, easy-to-perform, cost-effective, and safe alternative to fluoroscopy.
View article: Augmenting knowledge regarding Pediatric Septic Shock and golden-hour management practices among Pediatric Emergency department nurses: Impact of a structured teaching program in a tertiary-care teaching institution in South India
Augmenting knowledge regarding Pediatric Septic Shock and golden-hour management practices among Pediatric Emergency department nurses: Impact of a structured teaching program in a tertiary-care teaching institution in South India Open
Background: Clinical practice guidelines of the American Heart Association’s Pediatric Advanced Life Support program indicate that early recognition and treatment of pediatric septic shock significantly decreases mortality. Despite the man…
View article: Do Variations in Frontal Recess Anatomy Predispose to Mucocele Formation?
Do Variations in Frontal Recess Anatomy Predispose to Mucocele Formation? Open
Introduction Mucoceles are benign expansile cystic lesions commonly seen in the frontoethmoidal region. Objective To see if the distribution of frontal air cells predisposes to mucocele formation. Methods Retrospective review of all cases …
View article: Ultrasound-guided Genicular Nerve Block in Comparison to Intra-articular Steroid Injection in Chronic Pain Due to Osteoarthritis Knee: A Double-blind Randomised Controlled Trial
Ultrasound-guided Genicular Nerve Block in Comparison to Intra-articular Steroid Injection in Chronic Pain Due to Osteoarthritis Knee: A Double-blind Randomised Controlled Trial Open
Objective: The objective of this study was to assess the effectiveness of ultrasound (USG)-guided genicular nerve block (GNB) using bupivacaine in comparison to intra-articular corticosteroid (IACS) injection in reducing pain and improving…
View article: Anti-phosphohistone H3 (PHH3) as a proliferation marker to assess mitotic activity and to grade neuroendocrine neoplasms of hepatopancreaticobiliary (HPB) system
Anti-phosphohistone H3 (PHH3) as a proliferation marker to assess mitotic activity and to grade neuroendocrine neoplasms of hepatopancreaticobiliary (HPB) system Open
Background: The world health organization (WHO) classification of neuroendocrine neoplasms (NENs, i.e. neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs)) of the gastrointestinal system involves grading of these tumors by mi…
View article: Prevalence and potential impact of human pegivirus-1 on HIV-1 disease progression among Indian PLHIV
Prevalence and potential impact of human pegivirus-1 on HIV-1 disease progression among Indian PLHIV Open
Introduction: Human pegivirus-1 (HPgV-1) influences the pathogenesis and outcome of viral infections. We investigated the prevalence and impact of HPgV-1 due to the paucity of studies on Indian people living with HIV (PLHIV). Methodology: …
View article: Glomerulonephritis After Renal Transplatation in South Asia - Single Center Experience Over 5 Decades
Glomerulonephritis After Renal Transplatation in South Asia - Single Center Experience Over 5 Decades Open
Background With significant advances in the understanding of transplant immunology and a reduction in rejection rates, significant improvements in kidney allograft survival have been seen. The problem of recurrent and denovo glomerular dis…
View article: Effect of reconstituted, lyophilized cold aqueous extract of Aloe vera on human whole blood clotting time - A pilot study
Effect of reconstituted, lyophilized cold aqueous extract of Aloe vera on human whole blood clotting time - A pilot study Open
View article: Review of: "Correlation Between HbA1c and Body Mass Index Among Patients with High Lipid Profile Attending Johns Hopkins Aramco Healthcare Hospital in Saudi Arabia"
Review of: "Correlation Between HbA1c and Body Mass Index Among Patients with High Lipid Profile Attending Johns Hopkins Aramco Healthcare Hospital in Saudi Arabia" Open
Potential competing interests: No potential competing interests to declare.The study is well written; however, there is a very huge sample size, which is not necessary.I would recommend the author to estimate the sample size based on the s…
View article: Decellularized fetal collagen exhibits chondroinductive potential for bone marrow-derived mesenchymal stem cells by enhancing glycosaminoglycan production
Decellularized fetal collagen exhibits chondroinductive potential for bone marrow-derived mesenchymal stem cells by enhancing glycosaminoglycan production Open
Articular cartilage repair is challenging due to limited access to reparative cells and a lack of self-healing mechanisms. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are a promising therapeutic option, but their tendency to form …
View article: Cardiac Autonomic Dysfunction Measured as Reduced Heart Rate Variability, in the Intermediate Post-Covid State in Men
Cardiac Autonomic Dysfunction Measured as Reduced Heart Rate Variability, in the Intermediate Post-Covid State in Men Open
Background: A critical illness such as severe coronavirus disease 2019 (COVID-19) activates autonomic, endocrine, and emotional stress responses. Whether the manifestations of excessive stress experience persist beyond full recovery into t…
View article: Optimizing Surgical Management of Acute Invasive Fungal Sinusitis
Optimizing Surgical Management of Acute Invasive Fungal Sinusitis Open
The proposed surgical guidelines for AIFS allow for adequate surgical debridement with preservation of optimum functional status. Low revision surgery rates and good outcomes with minimal morbidity validate its usefulness.
View article: Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an alternative platinum-containing regimen in 116 patients with early triple negative breast cancer
Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an alternative platinum-containing regimen in 116 patients with early triple negative breast cancer Open
We assessed the efficacy, tolerability, and cost-effectiveness of a novel neoadjuvant regimen comprising docetaxel-cyclophosphamide alternating with epirubicin-cisplatin (ddDCEP) administered biweekly for 16 weeks in 116 patients with earl…
View article: Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India
Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India Open
We aimed to evaluate the predictive accuracy of InsuTAG index against M value of the hyperinsulinaemic-Euglycaemic clamp (HEC) procedure and fasting surrogate indices of insulin sensitivity/resistance in young, normoglycaemic, Asian Indian…
View article: Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an Alternative Platinum-Containing Regimen in 116 Patients with Early Triple Negative Breast Cancer
Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an Alternative Platinum-Containing Regimen in 116 Patients with Early Triple Negative Breast Cancer Open
We assessed the efficacy, tolerability, and cost-effectiveness of a novel neoadjuvant regimen comprising docetaxel-cyclophosphamide alternating with epirubicin-cisplatin (ddDCEP) administered biweekly for 16 weeks in 116 patients with earl…
View article: A Cross-sectional Study on Sleep among Indian Adolescents
A Cross-sectional Study on Sleep among Indian Adolescents Open
Background: Adolescent sleep deprivation affects their mental health, cardiovascular health, academic performance, and safety while on the road. This study analyzed sleep quality, hygiene, and daytime sleepiness among adolescents attending…
View article: Clinico-Radiological Evaluation for Longitudinal Assessment in Central Skull Base Osteomyelitis: Proposal of Novel Scoring System
Clinico-Radiological Evaluation for Longitudinal Assessment in Central Skull Base Osteomyelitis: Proposal of Novel Scoring System Open
View article: Bone Mineral Density and Serum Bone Turnover Markers among Post-Menarchal Girls from Rural South India
Bone Mineral Density and Serum Bone Turnover Markers among Post-Menarchal Girls from Rural South India Open
Background: The data on the bone mineral density (BMD) and bone turnover markers (BTMs) in Indian adolescents are limited. Objectives: To assess BMD at lumbar spine (LS, L1-L4) and femoral neck (FN) in South Indian post-menarchal girls and…
View article: Comparative evaluation of diabetic retinopathy screening programs in regular ophthalmology clinics versus integrated diabetic clinics within rural health-care services
Comparative evaluation of diabetic retinopathy screening programs in regular ophthalmology clinics versus integrated diabetic clinics within rural health-care services Open
BACKGROUND: Robust integration of diabetic retinopathy (DR) screening within health systems is essential to prevent DR-related blindness. This, however, remains a challenge in the developing world. The aim of this study was to evaluate two…
View article: Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells
Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells Open
Obtaining regeneration-competent cells and generating high-quality neocartilage are still challenges in articular cartilage tissue engineering. Although chondroprogenitor cells are a resident subpopulation of native cartilage and possess a…
View article: Longitudinal assessment of HCV core antigen kinetics to monitor therapeutic response in the age of DAAs
Longitudinal assessment of HCV core antigen kinetics to monitor therapeutic response in the age of DAAs Open
Background In the economy of therapeutic monitoring, an affordable viral marker is essential in the era of direct-acting antivirals (DAAs). We elucidated the kinetics of HCVcAg to delineate its precise role in monitoring therapeutic respon…
View article: Preoperative dose-dense docetaxel and cyclophosphamide alternating with epirubicin and cisplatin(ddDCEP): an effective, novel way of incorporating platinum in the treatment of early TNBC
Preoperative dose-dense docetaxel and cyclophosphamide alternating with epirubicin and cisplatin(ddDCEP): an effective, novel way of incorporating platinum in the treatment of early TNBC Open
Purpose The addition of carboplatin has improved pathological complete response (PCR) and event-free survival (EFS) and is becoming a new standard of care for early triple-negative breast cancer (TNBC). However, this comes at the expense o…
View article: Comparison of methods for the isolation and culture of Migratory chondroprogenitors from Human articular cartilage
Comparison of methods for the isolation and culture of Migratory chondroprogenitors from Human articular cartilage Open
Resident articular stem cells isolated using a migratory assay called Migratory Chondroprogenitors (MCPs) have emerged as a promising cellular therapeutic for the treatment of cartilage pathologies. In-vivo studies using MCPs report their …