Grace Roberts
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View article: A key role for hepatitis C virus NS5A serine 225 phosphorylation revealed by super-resolution microscopy
A key role for hepatitis C virus NS5A serine 225 phosphorylation revealed by super-resolution microscopy Open
NS5A is a multi-functional phosphoprotein that plays a key role in hepatitis C virus (HCV) genome replication and assembly. The consequences of NS5A phosphorylation for HCV biology remain largely undefined. We previously identified serine …
View article: The Chikungunya Virus nsP3 Macro Domain Inhibits Activation of the NF-κB Pathway
The Chikungunya Virus nsP3 Macro Domain Inhibits Activation of the NF-κB Pathway Open
The role of the chikungunya virus (CHIKV) non-structural protein 3 (nsP3) in the virus lifecycle is poorly understood. The protein comprises three domains. At the N-terminus is a macro domain, biochemically characterised to bind both RNA a…
View article: Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines
Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines Open
SARS-CoV-2 can efficiently infect both children and adults, albeit with morbidity and mortality positively associated with increasing host age and presence of co-morbidities. SARS-CoV-2 continues to adapt to the human population, resulting…
View article: Inhibition of the TLR4 signalling pathway with TAK-242 reduces RSV infection and cytokine release in primary airway epithelial cells
Inhibition of the TLR4 signalling pathway with TAK-242 reduces RSV infection and cytokine release in primary airway epithelial cells Open
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalisation in children worldwide, but there is still no vaccine or anti-viral treatment available. RSV has been implicated in the development of respiratory diseases …
View article: Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution
Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution Open
SARS-CoV-2 continues to evolve, resulting in several ‘variants of concern’ with novel properties. The factors driving SARS-CoV-2 fitness and evolution in the human respiratory tract remain poorly defined. Here, we provide evidence that bot…
View article: Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?
Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches? Open
View article: The Chikungunya virus nsP3 macro domain inhibits activation of the NF-κB pathway
The Chikungunya virus nsP3 macro domain inhibits activation of the NF-κB pathway Open
The role of the chikungunya virus (CHIKV) non-structural protein 3 (nsP3) in the virus lifecycle is poorly understood. The protein comprises 3 domains. The N-terminus is a macro domain, biochemically characterised to bind both RNA and ADP-…
View article: Characterising the role of the nsP3 macro domain in Chikungunya virus replication
Characterising the role of the nsP3 macro domain in Chikungunya virus replication Open
Chikungunya virus (CHIKV) causes an acute fever with debilitating joint pain. Spread by the Aedes species of mosquito, recent increases in global temperature, and mutations in the viral glycoproteins have facilitated outbreaks worldwide wi…
View article: Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research
Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research Open
View article: Manipulation of both virus- and cell-specific factors is required for robust transient replication of a hepatitis C virus genotype 3a sub-genomic replicon
Manipulation of both virus- and cell-specific factors is required for robust transient replication of a hepatitis C virus genotype 3a sub-genomic replicon Open
Hepatitis C virus (HCV) genotype (GT) 3 is the second most prevalent of the seven HCV genotypes and exhibits the greatest resistance to the highly potent, direct-acting antivirals (DAAs) that are currently in use. Previously a stable cell …
View article: SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy
SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy Open
View article: IRSL dating of fast-fading sanidine feldspars from Sulawesi, Indonesia
IRSL dating of fast-fading sanidine feldspars from Sulawesi, Indonesia Open
The volcanic origin of the sediments from Sulawesi, Indonesia, provides a particular challenge for luminescence dating due to the dim optically stimulated luminescence (OSL) from quartz, and the high anomalous fading rate in the infrared (…
View article: An Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer
An Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer Open
Because of its ease of handling, matrix-free 3D cell culture may be a useful model to study the influence of fibroblasts on breast cancer epithelial cells with use of epiFL culture medium taking this a step further towards a fully humanise…