Explanipedia

Partial‐ <span>EMT</span> cell state correlates with single cell pattern of invasion in head and neck <span>SCC</span> keratinocytes Open

Pyung Hun Park, L Israel, Michael H. Alexander, Grace Tartaglia, Harvey G South , et al. · 2025

The presence of a single metastatic lesion significantly decreases overall survival in patients with head and neck squamous cell carcinoma (HNSCC), and invasion of malignant keratinocytes is one of the initial steps required for HNSCC meta…

LB1179 Combination therapy with losartan and RTA-408 in a recessive dystrophic epidermolysis bullosa (RDEB) mouse model Open

Shahad Mohammed Halawani, Grace Tartaglia, B. Solomon, M. Alexander, P. Park , et al. · 2025

Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa Open

Grace Tartaglia, Ignacia Fuentes, Neil Patel, Abigail Varughese, L Israel , et al. · 2024

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited skin disease characterized by defects in type VII collagen leading to a range of fibrotic pathologies resulting from skin fragility, aberrant wound healing, and altered …

Trametinib-Induced Epidermal Thinning Accelerates a Mouse Model of Junctional Epidermolysis Bullosa Open

Grace Tartaglia, Pyung Hun Park, Michael H. Alexander, Alexander Nyström, Joel Rosenbloom , et al. · 2023

Junctional epidermolysis bullosa (JEB) patients experience skin and epithelial fragility due to a pathological deficiency in genes associated with epidermal adhesion. Disease severity ranges from post-natal lethality to localized skin invo…

593 Preventing fibrosis in patients with recessive dystrophic epidermolysis bullosa Open

Grace Tartaglia, N. Patel, I. Fuentes, Zachary Padron, L. Han , et al. · 2022

Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo Open

Qingqing Cao, Grace Tartaglia, Michael J. Alexander, Pyung Hung Park, Shiv Poojan , et al. · 2022

Impaired Wound Healing, Fibrosis, and Cancer: The Paradigm of Recessive Dystrophic Epidermolysis Bullosa Open

Grace Tartaglia, Qingqing Cao, Zachary Padron, Andrew P. South · 2021

Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a devastating skin blistering disease caused by mutations in the gene encoding type VII collagen (C7), leading to epidermal fragility, trauma-induced blistering, and long term, hard-to-h…

A Review of the Placenta and Trophoblast Induced Pluripotent Stem Cells in Autism Spectrum Disorder Research Open

Sona Jasani, Grace Tartaglia, Percy Luk Yeung, Chi Wei Lu · 2018

Autism spectrum disorder (ASD) imparts a tremendous health burden with psychological, social, and economic implications.The biology of ASD is complex involving genetic, molecular, hormonal and immunologic factors however the convergence po…

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