Grace Westerkamp
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View article: Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit
Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit Open
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from s…
View article: Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome
Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome Open
Compared to traditional band-limited power measures, aperiodic slope provides a more direct and validated index of excitation-inhibition balance. Our findings of reduced aperiodic slope in male subjects with FXS align with preclinical circ…
View article: FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions
FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions Open
Fragile X Syndrome (FXS), caused by the loss of function of the Fmr1 gene, is characterized by varying degrees of intellectual disability, autistic features, and sensory hypersensitivity. Despite phenotypic rescue in animal deletion models…
View article: Safety, Tolerability, and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist) in a Randomized Clinical Trial in a Subgroup of Patients with ASD
Safety, Tolerability, and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist) in a Randomized Clinical Trial in a Subgroup of Patients with ASD Open
This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast and bumetanide, tailored for the treatment of a clinically and biologically defined subgroup of patients with Autism Spectrum Disorder (ASD), name…
View article: Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder
Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder Open
Purpose Major depressive disorder (MDD) disproportionately affects those living with autism spectrum disorder (ASD) and is associated with significant impairment and treatment recidivism. Methods We studied the use of accelerated theta bur…
View article: CNN Brain Label-Maker: Computer Vision Based ICA Rejection EEG based System Architecture
CNN Brain Label-Maker: Computer Vision Based ICA Rejection EEG based System Architecture Open
The electroencephalogram (EEG) is a practical and reasonably applied tool for researching brain disorders and behavior changes. EEG offers a minimally restricted and non-invasive method, where the significant difficulties in utilizing EEG …
View article: Transient Seizure Clusters and Epileptiform Activity Following Widespread Bilateral Hippocampal Interneuron Ablation
Transient Seizure Clusters and Epileptiform Activity Following Widespread Bilateral Hippocampal Interneuron Ablation Open
Interneuron loss is a prominent feature of temporal lobe epilepsy in both animals and humans and is hypothesized to be critical for epileptogenesis. As loss occurs concurrently with numerous other potentially proepileptogenic changes, howe…
View article: Safety, Tolerability and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist), in a Randomized Clinical Trial in a Subgroup of Patients with ASD
Safety, Tolerability and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist), in a Randomized Clinical Trial in a Subgroup of Patients with ASD Open
This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast and bumetanide, tailored for the treatment of a specific subgroup of patients with Autism Spectrum Disorder (ASD), namely ASD Phenotype 1 (ASD-Phe…
View article: MiR-324-5p inhibition after intrahippocampal kainic acid-induced status epilepticus does not prevent epileptogenesis in mice
MiR-324-5p inhibition after intrahippocampal kainic acid-induced status epilepticus does not prevent epileptogenesis in mice Open
Background Acquired epilepsies are caused by an initial brain insult that is followed by epileptogenesis and finally the development of spontaneous recurrent seizures. The mechanisms underlying epileptogenesis are not fully understood. Mic…
View article: RETRACTED: Safety and tolerability of STP1 (PDE 3,4 inhibitor and NKCC1 inhibitor), in a subgroup of ASD patients (ASD-Phen1)
RETRACTED: Safety and tolerability of STP1 (PDE 3,4 inhibitor and NKCC1 inhibitor), in a subgroup of ASD patients (ASD-Phen1) Open
The authors have requested that this preprint be removed from Research Square.
View article: Gamma spectral event power is elevated in Fragile X Syndrome and associated with single trial gamma power during auditory chirp
Gamma spectral event power is elevated in Fragile X Syndrome and associated with single trial gamma power during auditory chirp Open
Background Fragile X syndrome (FXS) is a neurodevelopmental disorder resulting from silencing of the FMR1 gene. One of the most common and debilitating symptoms of FXS is sensory hyperarousal, especially in the auditory domain. Although th…