Graciela E. Delgado
YOU?
Author Swipe
View article: Associations between arterial stiffness, electrolytes, and hormones: Insights from the LURIC Study on cardiovascular health
Associations between arterial stiffness, electrolytes, and hormones: Insights from the LURIC Study on cardiovascular health Open
Background: Pulse pressure (PP), the difference between systolic (SBP) and diastolic blood pressure (DBP), is an essential marker of cardiovascular (CV) health and arterial stiffness. Elevated PP is linked to a higher risk of CV events, a …
View article: Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study
Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study Open
Inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), and interleukin-6 (IL-6), have been associated with an increased risk of future cardiovascular events. While they provide valuable progn…
View article: Polygenic prediction of body mass index and obesity through the life course and across ancestries
Polygenic prediction of body mass index and obesity through the life course and across ancestries Open
View article: A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Open
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program …
View article: Self-rated physical fitness predicts cardiovascular and all-cause mortality—implications for clinical decision-making
Self-rated physical fitness predicts cardiovascular and all-cause mortality—implications for clinical decision-making Open
Aims The study investigated the association between self-reported physical fitness (SRPF) and mortality in 3248 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study with a mean follow-up of 9.9 years. Methods and r…
View article: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes Open
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately …
View article: Associations between serum mineral concentrations and mortality by renal function in the Ludwigshafen Risk and Cardiovascular Health Study
Associations between serum mineral concentrations and mortality by renal function in the Ludwigshafen Risk and Cardiovascular Health Study Open
The association of serum concentrations of minerals and phosphate with overall and cardiovascular mortality based on renal function is poorly understood. 3307 patients (average age 62.7 ± 10.6 years) in the Ludwigshafen Risk and Cardiovasc…
View article: Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease
Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease Open
This study showed that CAC GRS is a new risk marker for CAD in three European cohorts, with added predictive value over the traditional CVD risk factors.
View article: Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles Open
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compa…
View article: Genetic risk score for coronary artery calcification predicts coronary artery disease beyond traditional risk factors
Genetic risk score for coronary artery calcification predicts coronary artery disease beyond traditional risk factors Open
Aim The modest added predictive value of the existing genetic risk scores (GRSs) for coronary artery disease (CAD) could be partly due to missing genetic components, hidden in the genetic architecture of intermediate phenotypes such as cor…
View article: Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis Open
View article: A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Open
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program …
View article: Mapping the aetiological foundations of the heart failure spectrum using human genetics
Mapping the aetiological foundations of the heart failure spectrum using human genetics Open
Summary paragraph Heart failure (HF), a syndrome of symptomatic fluid overload due to cardiac dysfunction, is the most rapidly growing cardiovascular disorder. Despite recent advances, mortality and morbidity remain high and treatment inno…
View article: Clusters of prediabetes and type 2 diabetes stratify all-cause mortality in a cohort of participants undergoing invasive coronary diagnostics
Clusters of prediabetes and type 2 diabetes stratify all-cause mortality in a cohort of participants undergoing invasive coronary diagnostics Open
View article: High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography
High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography Open
Background Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet. Aims The aim of our study was to inves…
View article: Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles Open
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compa…
View article: Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake Open
View article: Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH
Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH Open
View article: Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels
Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels Open
Background: Antithrombin, PC (protein C), and PS (protein S) are circulating natural anticoagulant proteins that regulate hemostasis and of which partial deficiencies are causes of venous thromboembolism. Previous genetic association studi…
View article: Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study Open
Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Ris…
View article: DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood
DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood Open
View article: Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Loci for insulin processing and secretion provide insight into type 2 diabetes risk Open
View article: Blood Pressure and Mortality in the 4D Study
Blood Pressure and Mortality in the 4D Study Open
Introduction: Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) are risk factors for cardiovascular mortality (CVM). Pulse pressure (PP) is an easily available parameter of vascul…
View article: The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC
The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC Open
Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different deg…
View article: Antithrombin, protein C and protein S: Genome and transcriptome wide association studies identify 7 novel loci regulating plasma levels
Antithrombin, protein C and protein S: Genome and transcriptome wide association studies identify 7 novel loci regulating plasma levels Open
Objective Antithrombin, protein C (PC) and protein S (PS) are circulating natural-anticoagulant proteins that regulate hemostasis and of which partial deficiencies are causes of venous thromboembolism. Previous genetic association studies …
View article: A saturated map of common genetic variants associated with human height
A saturated map of common genetic variants associated with human height Open
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes 1 . Here, using dat…
View article: Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality Open
Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (…
View article: Red blood cell fatty acid patterns from 7 countries: Focus on the Omega-3 index
Red blood cell fatty acid patterns from 7 countries: Focus on the Omega-3 index Open
Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different analytical methods have complicated inter-study and international comparisons. Here we report RBC FA data…
View article: Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis
Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis Open
View article: Gender- and subgroup-specific sensitivity analysis of alcohol consumption and mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Gender- and subgroup-specific sensitivity analysis of alcohol consumption and mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study Open