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View article: Developing novel Lin28 inhibitors by computer aided drug design
Developing novel Lin28 inhibitors by computer aided drug design Open
Lin28 is a key regulator of cancer stem cell gene network that promotes therapy-resistant tumor progression in various tumors. However, no Lin28 inhibitor has been approved to treat cancer patients, urging exploration of novel compounds as…
View article: Developing novel Lin28 inhibitors by computer aided drug design
Developing novel Lin28 inhibitors by computer aided drug design Open
Lin28 is a key regulator of the cancer stem cell gene network that promotes therapy-resistant tumor progression in various tumors. However, no Lin28 inhibitor has been approved to treat cancer patients, urging the exploration of novel comp…
View article: LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling
LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling Open
Although less common, melanoma is the deadliest form of skin cancer largely due to its highly metastatic nature. Currently, there are limited treatment options for metastatic melanoma and many of them could cause serious side effects. A be…
View article: Downregulation of tumor-suppressor gene <i>LHX6</i> in cancer: a systematic review
Downregulation of tumor-suppressor gene <i>LHX6</i> in cancer: a systematic review Open
Introduction . LIM Homeobox 6 (LHX6) encodes a LIM homeodomain transcription factor, contributes to tissue development and morphogenesis, and is mostly expressed in medial ganglionic eminence and odontogenic mesenchyme. However, it has bee…