Graeme F. Woodworth
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View article: IMG-33. Unveiling glioblastoma heterogeneity with deep learning derived MRI subtyping: insights from the global ReSPOND consortium
IMG-33. Unveiling glioblastoma heterogeneity with deep learning derived MRI subtyping: insights from the global ReSPOND consortium Open
PURPOSE This study aims to identify distinct imaging subtypes of glioblastoma using multi-modal MRIs from the ReSPOND consortium, providing insights into tumor heterogeneity to inform personalized treatment approaches. METHODS We analyzed …
View article: Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound
Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound Open
View article: Mechanistic insights and basis for real-time monitoring and closed-loop feedback control in sonodynamic therapy for glioblastoma
Mechanistic insights and basis for real-time monitoring and closed-loop feedback control in sonodynamic therapy for glioblastoma Open
Sonodynamic therapy (SDT) involves the administration of otherwise inactive agents that can be activated by acoustic energy ('sonosensitizers') to impart therapeutic effects. SDT is a treatment of significant clinical interest in glioblast…
View article: DSAI-08 MACHINE LEARNING-BASED PREDICTION OF INPATIENT CARE COSTS FOR PATIENTS WITH BRAIN METASTASES: A CLAIMS-BASED ANALYSIS
DSAI-08 MACHINE LEARNING-BASED PREDICTION OF INPATIENT CARE COSTS FOR PATIENTS WITH BRAIN METASTASES: A CLAIMS-BASED ANALYSIS Open
INTRODUCTION Brain metastases (BMs) are increasingly a cause of significant cancer-related morbidity, mortality, and economic burden. Predictive analytics providing BM-related risk-adjusted benefits and inpatient care costs (IPCC) are limi…
View article: The Deformability of the Mammalian Cell Nucleus is Determined by the Identity of the Lamin Rod Domain
The Deformability of the Mammalian Cell Nucleus is Determined by the Identity of the Lamin Rod Domain Open
Lamins are nuclear intermediate filament proteins with diverse functions, ranging from organizing chromatin and regulating gene expression to providing structural support to the nucleus. Mammalian cells express two types of lamins, A-type …
View article: Data-driven feedback augments ultrasound nanotheranostics in brain tumors
Data-driven feedback augments ultrasound nanotheranostics in brain tumors Open
The blood-brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease-related DNA from the brain unreliable. Here, we show that the acoustic emission content of focused ultraso…
View article: Standard Dose Versus Reduced Dose Single Fraction Preoperative Radiosurgery for Resected Brain Metastases (PROPS-BM) International Multicenter Cohort Study
Standard Dose Versus Reduced Dose Single Fraction Preoperative Radiosurgery for Resected Brain Metastases (PROPS-BM) International Multicenter Cohort Study Open
View article: Mbnl1: A Key Regulator of Hif-1α Mrna Stability, Hypoxia Memory, and Hypoxia-Induced Stemness in Glioblastoma
Mbnl1: A Key Regulator of Hif-1α Mrna Stability, Hypoxia Memory, and Hypoxia-Induced Stemness in Glioblastoma Open
View article: Acoustic Emissions Dose and Spatial Control of Blood-Brain Barrier Opening with Focused Ultrasound
Acoustic Emissions Dose and Spatial Control of Blood-Brain Barrier Opening with Focused Ultrasound Open
View article: An analysis of functional outcomes following laser interstitial thermal therapy for recurrent high-grade glioma
An analysis of functional outcomes following laser interstitial thermal therapy for recurrent high-grade glioma Open
OBJECTIVE Laser interstitial thermal therapy (LITT) is an emerging tool for treating a variety of focal brain lesions, including recurrent high-grade glioma (HGG). While the efficacy and uses of LITT have been well studied, the impact of t…
View article: Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond
Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond Open
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently r…
View article: Predicting peritumoral glioblastoma infiltration and subsequent recurrence using deep-learning–based analysis of multi-parametric magnetic resonance imaging
Predicting peritumoral glioblastoma infiltration and subsequent recurrence using deep-learning–based analysis of multi-parametric magnetic resonance imaging Open
The proposed model demonstrates that mpMRI analysis using deep learning can predict infiltration in the peri-tumoral brain region for GBM patients without needing to train a model using expert ROI drawings. Results for each institution dem…
View article: Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas
Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas Open
Infiltrating gliomas are challenging to treat, as the blood-brain barrier significantly impedes the success of therapeutic interventions. While some clinical trials for high-grade gliomas have shown promise, patient outcomes remain poor. M…
View article: Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials
Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials Open
View article: Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients
Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients Open
Purpose/objective(s) Treatment related lymphopenia is a known toxicity for glioblastoma (GBM) patients and several single-institution studies have linked lymphopenia with poor survival outcomes. We performed a systematic review and pooled …
View article: Carrier‐Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery
Carrier‐Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery Open
Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodyna…
View article: The Apple Vision Pro as a Neurosurgical Planning Tool: A Case Report
The Apple Vision Pro as a Neurosurgical Planning Tool: A Case Report Open
With its recent release, the Apple Vision Pro (Apple Inc., Cupertino, CA) represents a promising technological advancement of mixed reality in the field of neurosurgery and medicine more broadly. With all new technologies, it is critical t…
View article: NIMG-13. ROBUSTNESS OF PROGNOSTIC STRATIFICATION IN DE NOVO GLIOBLASTOMA PATIENTS ACROSS 22 GEOGRAPHICALLY DISTINCT INSTITUTIONS: INSIGHTS FROM THE RESPOND CONSORTIUM
NIMG-13. ROBUSTNESS OF PROGNOSTIC STRATIFICATION IN DE NOVO GLIOBLASTOMA PATIENTS ACROSS 22 GEOGRAPHICALLY DISTINCT INSTITUTIONS: INSIGHTS FROM THE RESPOND CONSORTIUM Open
PURPOSE Glioblastoma is the most prevalent primary malignant brain tumor in adults, with a median overall survival (OS) of approximately 15 months and only limited advancements in prognostication and survival prediction. This study aims to…
View article: RTID-01. A RANDOMIZED STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR BRAIN METASTASIS FROM NON-SMALL CELL LUNG CANCER (LIMITLESS)
RTID-01. A RANDOMIZED STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR BRAIN METASTASIS FROM NON-SMALL CELL LUNG CANCER (LIMITLESS) Open
BACKGROUND Blood-brain barrier disruption (BBBD) has been demonstrated, in preclinical models, to improve systemic drug delivery for BM. Low-intensity focused ultrasound (LIFU) with intravenously (IV) administered microbubble oscillators r…
View article: CTNI-55. A MULTICENTER STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND WITH SYSTEMIC MICROBUBBLE OSCILLATORS FOR BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)
CTNI-55. A MULTICENTER STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND WITH SYSTEMIC MICROBUBBLE OSCILLATORS FOR BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE) Open
BACKGROUND Liquid biopsy in glioblastoma (GBM) is hindered by a lack of requisite circulating-free DNA (cfDNA) blood levels in due to the blood-brain barrier (BBB). Real-time image-guided low-intensity focused ultrasound (LIFU) with intrav…
View article: Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium
Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium Open
Partial T2-FLAIR mismatch sign is highly specific for IDH mutation in WHO grade 4 gliomas.
View article: Risk Factors for Progression and Toxic Effects After Preoperative Stereotactic Radiosurgery for Patients With Resected Brain Metastases
Risk Factors for Progression and Toxic Effects After Preoperative Stereotactic Radiosurgery for Patients With Resected Brain Metastases Open
Importance Preoperative stereotactic radiosurgery (SRS) has been demonstrated as a feasible alternative to postoperative SRS for resectable brain metastases (BMs) with potential benefits in adverse radiation effects (AREs) and meningeal di…
View article: Surgical Decompression of Traumatic Cervical Spinal Cord Injury: A Pilot Study Comparing Real-Time Intraoperative Ultrasound After Laminectomy With Postoperative MRI and CT Myelography
Surgical Decompression of Traumatic Cervical Spinal Cord Injury: A Pilot Study Comparing Real-Time Intraoperative Ultrasound After Laminectomy With Postoperative MRI and CT Myelography Open
BACKGROUND: Decompression of the injured spinal cord confers neuroprotection. Compared with timing of surgery, verification of surgical decompression is understudied. OBJECTIVE: To compare the judgment of cervical spinal cord decompression…
View article: Fn14-Directed DART Nanoparticles Selectively Target Neoplastic Cells in Preclinical Models of Triple-Negative Breast Cancer Brain Metastasis
Fn14-Directed DART Nanoparticles Selectively Target Neoplastic Cells in Preclinical Models of Triple-Negative Breast Cancer Brain Metastasis Open
Triple-negative breast cancer (TNBC) patients with brain metastasis (BM) face dismal prognosis due to the limited therapeutic efficacy of the currently available treatment options. We previously demonstrated that paclitaxel-loaded PLGA-PEG…
View article: CTNI-46. PIVOTAL STUDY TO EVALUATE SAFETY AND EFFICACY OF EXABLATE MODEL 4000 USING MICROBUBBLE RESONATORS TO TEMPORARILY MEDIATE BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)
CTNI-46. PIVOTAL STUDY TO EVALUATE SAFETY AND EFFICACY OF EXABLATE MODEL 4000 USING MICROBUBBLE RESONATORS TO TEMPORARILY MEDIATE BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE) Open
BACKGROUND Glioblastoma (GBM) has dismal outcome of 14-16 months. One of the challenges of drug development in GBM is lack of requisite circulating-free (cfDNA) in blood samples to develop biomarker driven targeted therapy trials. The Exab…
View article: CTNI-10. RANDOMIZED PIVOTAL STUDY OF BLOOD-BRAIN BARRIER (BBB) DISRUPTION USING EXABLATE MODEL 4000 WITH STANDARD OF CARE (SOC) THERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) BRAIN METASTASES: LIMITLESS TRIAL
CTNI-10. RANDOMIZED PIVOTAL STUDY OF BLOOD-BRAIN BARRIER (BBB) DISRUPTION USING EXABLATE MODEL 4000 WITH STANDARD OF CARE (SOC) THERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) BRAIN METASTASES: LIMITLESS TRIAL Open
BACKGROUND NSCLC is the most common cause of brain metastases. The Exablate focused ultrasound with circulating microbubble resonators uses the concept of real-time imaging to treat small target spots focusing energy through the skull in n…
View article: Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment
Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment Open
View article: Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment Open
Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non‐central nervous system (non‐CNS) tumors. MRI guidance allows for precise placement of optical fi…
View article: The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors
The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors Open
View article: Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities
Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities Open