Graham C. Thompson
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View article: Correction: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial
Correction: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial Open
View article: Protocol for a multi-country retrospective observational paediatric sepsis epidemiological study (SENTINEL International)
Protocol for a multi-country retrospective observational paediatric sepsis epidemiological study (SENTINEL International) Open
Introduction Improving outcomes from sepsis in children is a WHO Global Health Priority, yet mortality from sepsis remains high, particularly in low- and middle-income countries (LMICs). This database from children with community-acquired …
View article: Opioid Administration and Reduction of Pediatric Ileocolic Intussusception
Opioid Administration and Reduction of Pediatric Ileocolic Intussusception Open
Importance Ileocolic intussusception is an important and painful cause of bowel obstruction in children. Its reduction is also painful, but neither sedation nor analgesia is routinely provided, in part due to concerns surrounding gastroint…
View article: Adverse events among early caregivers' COVID-19 vaccination correlated inversely with intention to vaccinate their children
Adverse events among early caregivers' COVID-19 vaccination correlated inversely with intention to vaccinate their children Open
Side effects experienced by caregivers are associated with their intention to vaccinate their children. Building of trust in vaccines, including communicating risks and benefits in the context of caregiver's experience, is important and ma…
View article: A randomised controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo <i>versus</i> Epinephrine and Dexamethasone (BIPED) study protocol
A randomised controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo <i>versus</i> Epinephrine and Dexamethasone (BIPED) study protocol Open
Introduction Bronchiolitis exerts a significant burden of illness on infants worldwide. National guidelines advise only supportive care. There is evidence that treating infants with bronchiolitis with a combination of inhaled epinephrine a…
View article: Caregivers Reported Post Covid-19 Vaccine Adverse Events and Intention to Vaccinate Their Children Against Covid-19
Caregivers Reported Post Covid-19 Vaccine Adverse Events and Intention to Vaccinate Their Children Against Covid-19 Open
View article: A randomized controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo versus Epinephrine and Dexamethasone (BIPED) study protocol
A randomized controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo versus Epinephrine and Dexamethasone (BIPED) study protocol Open
Background Bronchiolitis exerts a significant burden of illness on infants worldwide predominantly due to need for hospitalization. Currently only supportive care is advised by national guidelines for infants with bronchiolitis. There is e…
View article: Research capacity and limitations in Canadian paediatric emergency departments: An observational study on biomarker discovery
Research capacity and limitations in Canadian paediatric emergency departments: An observational study on biomarker discovery Open
Background Paediatric research is essential to acquire effective diagnoses and treatment for children, but it has historically been under-prioritized. The PRIMED study aimed to characterize the bio-profiles of children with appendicitis an…
View article: Gene Expression Profiling in Pediatric Appendicitis
Gene Expression Profiling in Pediatric Appendicitis Open
Importance Appendicitis is the most common indication for urgent surgery in the pediatric population, presenting across a range of severity and with variable complications. Differentiating simple appendicitis (SA) and perforated appendicit…
View article: Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception
Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception Open
Importance Ileocolic intussusception is an important cause of intestinal obstruction in children. Reduction of ileocolic intussusception using air or fluid enema is the standard of care. This likely distressing procedure is usually perform…
View article: Willingness to vaccinate children against COVID-19 declined during the pandemic
Willingness to vaccinate children against COVID-19 declined during the pandemic Open
View article: 61 Analgesia and sedation for pediatric ileocolic intussusception: a global, multicenter, cross-sectional study (PAINT)
61 Analgesia and sedation for pediatric ileocolic intussusception: a global, multicenter, cross-sectional study (PAINT) Open
Background Ileocolic intussusception requires timely reduction to prevent complications. Reduction can be distressing. Sedation is uncommon due to controversial beliefs surrounding an increased risk of perforation. Analgesia and sedation p…
View article: 63 Translational Research Capacity in Canadian Pediatric Emergency Departments Participating in the Precision Medicine for Improving the Diagnosis of Pediatric Appendicitis in the Emergency Department (PRIMED) Study
63 Translational Research Capacity in Canadian Pediatric Emergency Departments Participating in the Precision Medicine for Improving the Diagnosis of Pediatric Appendicitis in the Emergency Department (PRIMED) Study Open
Background Pediatric clinical and translational research are essential to acquire effective diagnostic and treatment options for children, but they are underfunded and under prioritized in comparison to research focused on treatments for a…
View article: Should COVID-19 vaccines be mandated in schools? - an international caregiver perspective
Should COVID-19 vaccines be mandated in schools? - an international caregiver perspective Open
View article: Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review Open
View article: Providing optimal care for active youth in Canada.
Providing optimal care for active youth in Canada. Open
Sports are important activities for youth, with millions of children and adolescents participating in organized sports and recreational activities every year. Sports participation has many benefits but can also cause injuries, accounting f…
View article: A multicentre Canadian survey of caregiver perspectives on COVID vaccine-related pain and stress for their family
A multicentre Canadian survey of caregiver perspectives on COVID vaccine-related pain and stress for their family Open
Background: Caregiver hesitancy for their children to receive the COVID-19 vaccine remains due to concerns regarding safety and efficacy, but also due to fear of vaccine administration-related pain and distress. Study objectives were to de…
View article: The responsibility to care: lessons learned from emergency department workers’ perspectives during the first wave of the COVID-19 pandemic in Canada
The responsibility to care: lessons learned from emergency department workers’ perspectives during the first wave of the COVID-19 pandemic in Canada Open
View article: Providing optimal care for active youth in Canada
Providing optimal care for active youth in Canada Open
Sports are important activities for youth, with millions of children and adolescents participating in organized sports and recreational activities every year. Sports participation has many benefits but can also cause injuries, accounting f…
View article: Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial
Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial Open
Objectives Despite a lack of evidence demonstrating superiority to non-steroidal anti-inflammatory drugs, like ketorolac, that are associated with lower risk of harms, opioids remain the most prescribed analgesic for acute abdominal pain. …
View article: Comparison of Two Automated Targeted Metabolomics Programs to Manual Profiling by an Experienced Spectroscopist for 1H-NMR Spectra
Comparison of Two Automated Targeted Metabolomics Programs to Manual Profiling by an Experienced Spectroscopist for 1H-NMR Spectra Open
Automated programs that carry out targeted metabolite identification and quantification using proton nuclear magnetic resonance spectra can overcome time and cost barriers that limit metabolomics use. However, their performance needs to be…
View article: National COVID-19 vaccine program progress and parents’ willingness to vaccinate their children
National COVID-19 vaccine program progress and parents’ willingness to vaccinate their children Open
Vaccinating children against COVID-19 is critical as a public health strategy in order to reach herd immunity and prevent illness among children and adults. The aim of the study was to identify correlation between willingness to vaccinate …
View article: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial
PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial Open
View article: 29 Caregiver-Reported Delay in Presentation to Pediatric Emergency Departments for Fear of Contracting COVID-19: A multinational cross-sectional study
29 Caregiver-Reported Delay in Presentation to Pediatric Emergency Departments for Fear of Contracting COVID-19: A multinational cross-sectional study Open
Primary Subject area Public Health and Preventive Medicine Background Visits to pediatric emergency departments have decreased up to 75% during the pandemic, with corresponding increases in high acuity visits, inpatient admissions, and int…
View article: Caregiver Willingness to Vaccinate Their Children against COVID-19 after Adult Vaccine Approval
Caregiver Willingness to Vaccinate Their Children against COVID-19 after Adult Vaccine Approval Open
Vaccines against COVID-19 are likely to be approved for children under 12 years in the near future. Understanding vaccine hesitancy in parents is essential for reaching herd immunity. A cross-sectional survey of caregivers in 12 emergency …
View article: Metabolomics and Inflammatory Mediator Profiling for the Differentiation of Life-Threatening and Non-Severe Appendicitis in the Pediatric Population
Metabolomics and Inflammatory Mediator Profiling for the Differentiation of Life-Threatening and Non-Severe Appendicitis in the Pediatric Population Open
While children with appendicitis often have excellent clinical outcomes, some develop life-threatening complications including sepsis and organ dysfunction requiring pediatric intensive care unit (PICU) support. Our study applied a metabol…
View article: Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study
Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study Open
View article: Novel Molecular Biomarkers and Diagnosis of Acute Appendicitis in Children
Novel Molecular Biomarkers and Diagnosis of Acute Appendicitis in Children Open
Reliable and efficient diagnosis of pediatric appendicitis is essential for the establishment of a clinical management plan and improvement of patient outcomes. Current strategies used to diagnose a child presenting with a suspected append…
View article: Association Between Intravenous Magnesium Therapy in the Emergency Department and Subsequent Hospitalization Among Pediatric Patients With Refractory Acute Asthma
Association Between Intravenous Magnesium Therapy in the Emergency Department and Subsequent Hospitalization Among Pediatric Patients With Refractory Acute Asthma Open
ClinicalTrials.gov: NCT01429415.
View article: Magnetic Resonance Imaging Provides Useful Diagnostic Information Following Equivocal Ultrasound in Children With Suspected Appendicitis
Magnetic Resonance Imaging Provides Useful Diagnostic Information Following Equivocal Ultrasound in Children With Suspected Appendicitis Open
Purpose: In Canada, ultrasonography is the primary imaging modality for children with suspected appendicitis, yet equivocal studies are common. Magnetic resonance imaging provides promise as an adjunct imaging strategy. The primary objecti…