Graham Cooper
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View article: Diagnostic strategies for suspected acute aortic syndrome: systematic review, meta-analysis, decision-analytic modelling and value of information analysis
Diagnostic strategies for suspected acute aortic syndrome: systematic review, meta-analysis, decision-analytic modelling and value of information analysis Open
Background Acute aortic syndrome is a life-threatening condition that requires urgent diagnosis with computed tomographic angiography. Diagnostic technologies, including clinical scores and biomarkers, can be used to select patients presen…
View article: Decision analytical modelling of strategies for investigating suspected acute aortic syndrome
Decision analytical modelling of strategies for investigating suspected acute aortic syndrome Open
Background Acute aortic syndrome (AAS) requires urgent diagnosis with computed tomographic angiography (CTA). Diagnostic strategies need to weigh the benefits of detecting AAS against the costs of using CTA with a low yield of AAS when the…
View article: Evaluating current acute aortic syndrome pathways: Collaborative Acute Aortic Syndrome Project (CAASP)
Evaluating current acute aortic syndrome pathways: Collaborative Acute Aortic Syndrome Project (CAASP) Open
Background Diagnosis of acute aortic syndrome is challenging and associated with high perihospital mortality rates. The study aim was to evaluate current pathways and understand the chronology of acute aortic syndrome patient care. Method …
View article: Diagnostic accuracy of alternative biomarkers for acute aortic syndrome: a systematic review
Diagnostic accuracy of alternative biomarkers for acute aortic syndrome: a systematic review Open
Background D-dimer is the only biomarker currently recommended in guidelines for the diagnosis of acute aortic syndrome (AAS). We undertook a systematic review to determine whether any alternative biomarkers could be useful in AAS diagnosi…
View article: Management of acute aortic dissection in critical care
Management of acute aortic dissection in critical care Open
Aortic dissections are associated with significant mortality and morbidity, with rapid treatment paramount. They are caused by a tear in the intimal lining of the aorta that extends into the media of the wall. Blood flow through this tear …
View article: Determinants of outcomes following surgery for type A acute aortic dissection: the UK National Adult Cardiac Surgical Audit
Determinants of outcomes following surgery for type A acute aortic dissection: the UK National Adult Cardiac Surgical Audit Open
Aims Operability of type A acute aortic dissections (TAAAD) is currently based on non-standardized decision-making process, and it lacks a disease-specific risk evaluation model that can predict mortality. We investigated patient, intraope…
View article: Neuroprotective strategies in acute aortic dissection: an analysis of the UK National Adult Cardiac Surgical Audit
Neuroprotective strategies in acute aortic dissection: an analysis of the UK National Adult Cardiac Surgical Audit Open
OBJECTIVES The risk of brain injury following surgery for type A aortic dissection (TAAD) remains substantial and no consensus has still been reached on which neuroprotective technique should be preferred. We aimed to investigate the assoc…
View article: Heritage Hack - co_LAB in Practice
Heritage Hack - co_LAB in Practice Open
In the run-up to the HeritageDot Conference, the co_LAB team facilitated a 3-day intensive 'Heritage Hack' workshop in association with the Centre for Creativity and Culture, Lincoln Conservation Lab, MACE and the International Bomber Comm…
View article: Journalists as Design Partners for AI
Journalists as Design Partners for AI Open
We report on a project exploring the development of an AI-enabled system for researching and verifying news articles. In particular, we underscore the value of journalists in the role of designers in a wider multi-disciplinary team includi…
View article: Unwarranted Variation in the Quality of Care for Patients With Diseases of the Thoracic Aorta
Unwarranted Variation in the Quality of Care for Patients With Diseases of the Thoracic Aorta Open
Background Thoracic aortic disease has a high mortality. We sought to establish the contribution of unwarranted variation in care to regional differences in outcomes observed in patients with thoracic aortic disease in England. Methods and…