Graham H. Diering
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View article: Cell Type-Specific Contributions of UBE3A to Angelman Syndrome Behavioral Phenotypes
Cell Type-Specific Contributions of UBE3A to Angelman Syndrome Behavioral Phenotypes Open
Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by loss of expression of the maternal UBE3A allele and is characterized by a constellation of impactful neurologic symptoms. While previous work has uncovered outsized con…
View article: Unbiased genetics identifies a glutamatergic signaling network as a mediator of daily sleep patterns
Unbiased genetics identifies a glutamatergic signaling network as a mediator of daily sleep patterns Open
Sleep is a fundamental, conserved behavior important for survival. In many species, sleep behavior is controlled by poorly understood interactions between a system of circadian rhythms (CR), which promote sleep at ecologically appropriate …
View article: Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols
Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols Open
Lentiviral vector-transduced T cells were approved by the FDA as gene therapy anti-cancer medications. Little is known about the effects of host genetic variation on the safety and efficacy of the lentiviral vector gene delivery system. To…
View article: Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols
Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols Open
Lentiviral vector-transduced T cells were approved by the FDA as gene therapy anti-cancer medications. Little is known about the effects of host genetic variation on the safety and efficacy of the lentiviral vector gene delivery system. To…
View article: Neurons and astrocytes have distinct organelle signatures and responses to stress
Neurons and astrocytes have distinct organelle signatures and responses to stress Open
Summary Neurons and astrocytes play critical yet divergent roles in brain physiology and neurological conditions. Intracellular organelles are integral to cellular function. However, an in-depth characterization of organelles in live brain…
View article: Developing forebrain synapses are uniquely vulnerable to sleep loss
Developing forebrain synapses are uniquely vulnerable to sleep loss Open
Sleep is an essential behavior that supports lifelong brain health and cognition. Neuronal synapses are a major target for restorative sleep function and a locus of dysfunction in response to sleep deprivation (SD). Synapse density is high…
View article: Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols
Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols Open
Lentiviral vector-transduced T-cells were approved by the FDA as gene therapy anti-cancer medications. Little is known about the host genetic variation effects on the safety and efficacy of the lentiviral vector gene delivery system. To na…
View article: Sleep Disruption Precedes Forebrain Synaptic Tau Burden and Contributes to Cognitive Decline in a Sex-Dependent Manner in the P301S Tau Transgenic Mouse Model
Sleep Disruption Precedes Forebrain Synaptic Tau Burden and Contributes to Cognitive Decline in a Sex-Dependent Manner in the P301S Tau Transgenic Mouse Model Open
Sleep disruption and impaired synaptic processes are common features in neurodegenerative diseases, including Alzheimer's disease (AD). Hyperphosphorylated Tau is known to accumulate at neuronal synapses in AD, contributing to synapse dysf…
View article: The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1
The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1 Open
During neuronal development, dynamic filopodia emerge from dendrites and mature into functional dendritic spines during synaptogenesis. Dendritic filopodia and spines respond to extracellular cues, influencing dendritic spine shape and siz…
View article: Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration
Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration Open
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline. Therefore, treatments design…
View article: Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration
Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration Open
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline. Therefore, treatments design…
View article: The links between sleep and Alzheimer’s disease
The links between sleep and Alzheimer’s disease Open
The causes of Alzheimer's disease, a brain disorder, are still far from fully understood.At the University of North Carolina at Chapel Hill in the US, Dr Graham Diering and Dr Shenée Martin believe that the quality of our sleep could be a …
View article: Developing forebrain synapses are uniquely vulnerable to sleep loss
Developing forebrain synapses are uniquely vulnerable to sleep loss Open
Sleep is an essential behavior that supports lifelong brain health and cognition. Neuronal synapses are a major target for restorative sleep function and a locus of dysfunction in response to sleep deprivation (SD). Synapse density is high…
View article: Sleep disruption precedes forebrain synaptic Tau burden and contributes to cognitive decline in a sex-dependent manner in the P301S Tau transgenic mouse model
Sleep disruption precedes forebrain synaptic Tau burden and contributes to cognitive decline in a sex-dependent manner in the P301S Tau transgenic mouse model Open
Background Sleep is an essential process that supports brain health and cognitive function in part through the modification of neuronal synapses. Sleep disruption, and impaired synaptic processes, are common features in neurodegenerative d…
View article: Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity Open
Tau-mediated toxicity is associated with cognitive decline and Alzheimer's disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction.…
View article: Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc
Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc Open
Sleep is a conserved and essential process that supports learning and memory. Synapses are a major target of sleep function and a locus of sleep need. Evidence in the literature suggests that the need for sleep has a cellular or microcircu…
View article: Coordinated Regulation of CB1 Cannabinoid Receptors and Anandamide Metabolism Stabilizes Network Activity during Homeostatic Downscaling
Coordinated Regulation of CB1 Cannabinoid Receptors and Anandamide Metabolism Stabilizes Network Activity during Homeostatic Downscaling Open
Neurons express overlapping homeostatic mechanisms to regulate synaptic function and network properties in response to perturbations of neuronal activity. Endocannabinoids (eCBs) are bioactive lipids synthesized in the postsynaptic compart…
View article: Tonic endocannabinoid signaling supports sleep through development in both sexes
Tonic endocannabinoid signaling supports sleep through development in both sexes Open
Sleep is an essential behavior that supports brain function and cognition throughout life, in part by acting on neuronal synapses. The synaptic signaling pathways that mediate the restorative benefits of sleep are not fully understood, par…
View article: Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice
Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice Open
Opioid misuse has dramatically increased over the last few decades resulting in many people suffering from opioid use disorder (OUD). The prevalence of opioid overdose has been driven by the development of new synthetic opioids, increased …
View article: Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice
Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice Open
Background: Patients with autism spectrum disorder (ASD) experience high rates of sleep disruption beginning early in life, however the developmental consequences of this disruption are not understood. We examined sleep behavior and the co…
View article: Tonic endocannabinoid signaling supports sleep through development in both sexes
Tonic endocannabinoid signaling supports sleep through development in both sexes Open
Sleep is an essential behavior that supports brain function and cognition throughout life, in part by acting on neuronal synapses. The synaptic signaling pathways that mediate the restorative benefits of sleep are not fully understood, par…
View article: Decision letter: An essential role for MEF2C in the cortical response to loss of sleep in mice
Decision letter: An essential role for MEF2C in the cortical response to loss of sleep in mice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neuronal activity and gene expression in r…
View article: Mania‐ and anxiety‐like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice
Mania‐ and anxiety‐like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice Open
Genome‐wide association studies linked diacylglycerol kinase eta and iota to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized…