Graham I. Harrison
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View article: A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo
A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo Open
Significance Solar UV radiation (UVR) causes sunburn but initiates the first step of vitamin D synthesis, which is the formation of previtamin D 3 (pre-D 3 ) in skin. The gold standard for assessing vitamin D is serum 25-hydroxyvitamin D 3…
View article: A study into how ultraviolet radiation from the sun effects genes in the skin
A study into how ultraviolet radiation from the sun effects genes in the skin Open
The sun emits two main types of ultraviolet radiation (UVR): UVB (~5%) and UVA (~95%). We know that UVR from the sun causes sunburn (inflammation) as well as many other adverse (negative) effects including weakening the skin's immunity, ac…
View article: Cost‐effectiveness of the HepCATT intervention in specialist drug clinics to improve case‐finding and engagement with HCV treatment for people who inject drugs in England
Cost‐effectiveness of the HepCATT intervention in specialist drug clinics to improve case‐finding and engagement with HCV treatment for people who inject drugs in England Open
Background and Aims People who inject drugs (PWID) are at high risk of hepatitis C virus (HCV) infection; however, ~50% are undiagnosed in England and linkage‐to‐care is poor. This study investigated the cost‐effectiveness of an interventi…
View article: Optimal sunscreen use allows vitamin D synthesis
Optimal sunscreen use allows vitamin D synthesis Open
Vitamin D, vital for bone health, is produced by the skin in response to ultraviolet radiation (UVR) from sunlight. However, as well as being the main source of vitamin D, UVR is a major cause of skin cancer. This has led to questions abou…
View article: Dose and time effects of solar‐simulated ultraviolet radiation on the <i>in vivo</i> human skin transcriptome
Dose and time effects of solar‐simulated ultraviolet radiation on the <i>in vivo</i> human skin transcriptome Open
The UV radiation doses of this acute study are readily achieved daily during holidays in the sun, suggesting that the skin transcriptional profile of 'typical' holiday makers is markedly deregulated. What's already known about this topic? …
View article: Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn
Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn Open
Sunscreens may be used to prevent sunburn yet allow vitamin D synthesis. A high UVA-PF sunscreen enables significantly higher vitamin D synthesis than a low UVA-PF sunscreen because the former, by default, transmits more UVB than the latte…
View article: Optimal sunscreen use prevents holiday erythema
Optimal sunscreen use prevents holiday erythema Open
Rates of skin cancer are increasing more rapidly in the UK than any other form of cancer. The deadliest form of the disease is melanoma skin cancer, which affects 128% more people now than it did 28 years ago. Sun protection factors (SPFs)…
View article: The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus‐infected people who inject drugs in England
The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus‐infected people who inject drugs in England Open
Background and Aims Previous studies have shown low rates of diagnosis and treatment of hepatitis C virus (HCV) infection in people who inject drugs (PWID). Our aims were to test the effect of a complex intervention [Hepatitis C Awareness …
View article: Sunscreen applied at ≥ 2 mg cm<sup>−2</sup>during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐induced<scp>DNA</scp>damage and suppression of acquired immunity
Sunscreen applied at ≥ 2 mg cm<sup>−2</sup>during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐induced<span>DNA</span>damage and suppression of acquired immunity Open
Optimal sunscreen use prevents erythema during a sunny holiday. Erythema predicts suppression of CHS (implying a shared action spectrum). Given that erythema and CPDs share action spectra, the data strongly suggest that optimal sunscreen u…
View article: Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25-hydroxyvitamin D<sub>3</sub>, after a summer holiday in Northern Europe
Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25-hydroxyvitamin D<sub>3</sub>, after a summer holiday in Northern Europe Open
Careful consideration must be given to the health outcomes of childhood solar exposure, and a much better understanding of the risk-benefit relationships of such exposure is required. Rigorous photoprotection is necessary for children, eve…
View article: Understanding hepatitis C intervention success—Qualitative findings from the Hep<scp>CATT</scp> study
Understanding hepatitis C intervention success—Qualitative findings from the Hep<span>CATT</span> study Open
Summary The United Kingdom has committed to eliminating viral hepatitis as a public health threat. Innovative interventions for marginalized populations are required to realize this goal. In 2016, the Hep CATT study team implemented a comp…
View article: Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo
Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo Open
The cyclobutane pyrimidine dimer (CPD) is a potentially mutagenic DNA photolesion that is the basis of most skin cancers. There are no data on DNA protection by sunscreens under typical conditions of use. The study aim was to determine suc…
View article: The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD3
The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD3 Open
View article: Hepatitis C – Assessment to Treatment Trial (HepCATT) in primary care: study protocol for a cluster randomised controlled trial
Hepatitis C – Assessment to Treatment Trial (HepCATT) in primary care: study protocol for a cluster randomised controlled trial Open