Graham J. Bitzer
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View article: Co-administration of DTaP and mRNA COVID-19 vaccines results in altered immune profile and enhanced protection against aerosol challenge of B. pertussis in mice 3042
Co-administration of DTaP and mRNA COVID-19 vaccines results in altered immune profile and enhanced protection against aerosol challenge of B. pertussis in mice 3042 Open
Description Children routinely receive COVID-19 mRNA vaccines alongside other regularly scheduled immunizations. It is known that mRNA vaccines are pro-inflammatory in nature which lead to protective immunity. Our goal was to investigate t…
View article: Breaking the silence—role of MucR as a virulence determinant in <i>Brucella</i>
Breaking the silence—role of MucR as a virulence determinant in <i>Brucella</i> Open
The Zn finger protein MucR is an H-NS-like protein that serves as a gene silencer and nucleoid-structuring protein in the α-proteobacteria. MucR is also an essential virulence determinant in Brucella , where it directly and indirectly cont…
View article: Virus-like particles displaying the mature C-terminal domain of filamentous hemagglutinin are immunogenic and protective against <i>Bordetella pertussis</i> respiratory infection in mice
Virus-like particles displaying the mature C-terminal domain of filamentous hemagglutinin are immunogenic and protective against <i>Bordetella pertussis</i> respiratory infection in mice Open
Bordetella pertussis, the bacterium responsible for whooping cough, remains a significant public health challenge despite the existing licensed pertussis vaccines. Current acellular pertussis vaccines, though having favorable reactogenicit…
View article: Immunization with an mRNA DTP vaccine protects against pertussis in rats
Immunization with an mRNA DTP vaccine protects against pertussis in rats Open
Bordetella pertussis is a Gram-negative bacterium that is the causative agent of the respiratory disease known as pertussis. Since the switch to the acellular vaccines of DTaP and Tap, pertussis cases in the US have risen and cyclically fa…
View article: Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice
Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice Open
Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over time resulting in cyclic epidemics of pertussis. The mes…
View article: BECC438b TLR4 agonist supports unique immune response profiles from nasal and muscular DTaP pertussis vaccines in murine challenge models
BECC438b TLR4 agonist supports unique immune response profiles from nasal and muscular DTaP pertussis vaccines in murine challenge models Open
The protection afforded by acellular pertussis vaccines wanes over time, and there is a need to develop improved vaccine formulations. Options to improve the vaccines involve the utilization of different adjuvants and administration via di…
View article: Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge
Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge Open
The murine Bordetella pertussis challenge model has been utilized in preclinical research for decades. Currently, inconsistent methodologies are employed by researchers across the globe, making it difficult to compare findings. The objecti…
View article: Protocol for aerosolization challenge of mice with Bordetella pertussis
Protocol for aerosolization challenge of mice with Bordetella pertussis Open
View article: CpG 1018® adjuvant enhances Tdap immune responses against Bordetella pertussis in mice
CpG 1018® adjuvant enhances Tdap immune responses against Bordetella pertussis in mice Open
Bordetella pertussis is the causative agent of whooping cough (pertussis), a severe respiratory disease that can be fatal, particularly in infants. Despite high vaccine coverage, pertussis remains a problem because the currently used DTaP …
View article: Erratum for Wolf et al., “Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice”
Erratum for Wolf et al., “Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice” Open
View article: Serological survey of SARS-CoV-2 incidence conducted at a rural West Virginia hospital
Serological survey of SARS-CoV-2 incidence conducted at a rural West Virginia hospital Open
The SARS-CoV-2 pandemic has affected all types of global communities. Differences in urban and rural environments have led to varying levels of transmission within these subsets of the population. To fully understand the prevalence and imp…
View article: Mucosal immunization with DTaP confers protection against <i>Bordetella pertussis</i> infection and cough in Sprague-Dawley rats
Mucosal immunization with DTaP confers protection against <i>Bordetella pertussis</i> infection and cough in Sprague-Dawley rats Open
Pertussis is a respiratory disease caused by the Gram-negative pathogen, Bordetella pertussis ( Bp ). The transition from a whole cell pertussis vaccine (wP; DTP) to an acellular pertussis vaccine (aP; DTaP; Tdap) correlates with an increa…
View article: Re-investigating the coughing rat model of pertussis to understand<i>Bordetella pertussis</i>pathogenesis
Re-investigating the coughing rat model of pertussis to understand<i>Bordetella pertussis</i>pathogenesis Open
Bordetella pertussis ( Bp ) is a highly contagious bacterium that is the causative agent of whooping cough (pertussis). Currently, acellular pertussis vaccines (aP; DTaP; Tdap) are used to prevent pertussis disease. However, it is clear th…
View article: Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice
Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice Open
Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune response seeded in the respiratory tract. An individual, once convalescent, exhibits long-term immunity to the pathogen.