Graham J. Day
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View article: Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase
Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase Open
Advanced cell therapies require robust matrices for enhanced efficacy and delivery, but fabricating cell‐specific hydrogels with strong tissue adhesiveness remains challenging. Cell membrane engineering offers a non‐genetic strategy to mod…
View article: Probiotic‐Based Materials as Living Therapeutics
Probiotic‐Based Materials as Living Therapeutics Open
The growing demand for safer, more targeted therapeutics requires the development of advanced biomaterials. Among these, Engineered Living Materials (ELMs)—which integrate synthetic biology with material science—are emerging as promising p…
View article: 3D Bioprinted Engineered Living Microreactors for Continuous Organophosphorus Compound Degradation
3D Bioprinted Engineered Living Microreactors for Continuous Organophosphorus Compound Degradation Open
Engineered living materials (ELMs) are poised to play a pivotal role in addressing critical global environmental challenges through advances in green energy production, biosensing and bioremediation. When coupled with advanced manufacturin…
View article: Damping and vibration properties of alginate–poloxamer hydrogels doped with sepiolite and cactus fibers
Damping and vibration properties of alginate–poloxamer hydrogels doped with sepiolite and cactus fibers Open
We investigated a novel class of composite hydrogels composed of alginate, poloxamer, sepiolite, and cactus fibers for vibration damping applications. Using a design of experiments methodology, we systematically correlated manufacturing pa…
View article: Tunable network architecture in a hydrogel with extreme vibration damping properties
Tunable network architecture in a hydrogel with extreme vibration damping properties Open
Damping technologies aim to control the loads and deformations generated by ambient or forced vibrations in structures and machineries used in transport applications and construction. Traditionally, the materials used in damping devices ar…
View article: Tunable porosity in a hydrogel with extreme vibration damping properties
Tunable porosity in a hydrogel with extreme vibration damping properties Open
We have developed hydrogel systems with tunable porosity through dialysis casting by varying alginate and poloxamer compositions from 0% to 10%. These gels feature diverse porosity topologies, yielding loss factors between 16% and 29% in t…
View article: Tunable porosity in a hydrogel with extreme vibration damping properties
Tunable porosity in a hydrogel with extreme vibration damping properties Open
We have developed hydrogel systems with tunable porosity through dialysis casting by varying alginate and poloxamer compositions from 0% to 10%. These gels feature diverse porosity topologies, yielding loss factors between 16% and 29% in t…
View article: Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels
Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels Open
This paper describes the extrusion pressure’s effect on composite hydrogel inks’ filaments subjected to three point bending collapse tests. The composite considered in this work consists of an alginate-poloxamer hydrogel reinforced with fl…
View article: A Dual‐Purpose Non‐Canonical Amino Acid for the Expanded Genetic Code: Combining Metal‐Binding and Click Chemistry
A Dual‐Purpose Non‐Canonical Amino Acid for the Expanded Genetic Code: Combining Metal‐Binding and Click Chemistry Open
A rationally designed dual‐purpose non‐canonical amino acid (Trz) has been synthesised and successfully incorporated into a protein scaffold by genetic code expansion. Trz contains a 5‐pyridyl‐1,2,4‐triazine system, which allows for invers…
View article: A Dual‐Purpose Non‐Canonical Amino Acid for the Expanded Genetic Code: Combining Metal‐Binding and Click Chemistry
A Dual‐Purpose Non‐Canonical Amino Acid for the Expanded Genetic Code: Combining Metal‐Binding and Click Chemistry Open
A rationally designed dual‐purpose non‐canonical amino acid (Trz) has been synthesised and successfully incorporated into a protein scaffold by genetic code expansion. Trz contains a 5‐pyridyl‐1,2,4‐triazine system, which allows for invers…
View article: Partitioning of an Enzyme‐Polymer Surfactant Nanocomplex into Lipid‐Rich Cellular Compartments Drives In Situ Hydrolysis of Organophosphates
Partitioning of an Enzyme‐Polymer Surfactant Nanocomplex into Lipid‐Rich Cellular Compartments Drives In Situ Hydrolysis of Organophosphates Open
Most organophosphates (OPs) are hydrophobic, and after exposure, can sequester into lipophilic regions within the body, such as adipose tissue, resulting in long term chronic effects. Consequently, there is an urgent need for therapeutic a…
View article: Flax fibre reinforced alginate poloxamer hydrogel: assessment of mechanical and 4D printing potential
Flax fibre reinforced alginate poloxamer hydrogel: assessment of mechanical and 4D printing potential Open
A new 3D bioprinted biomaterial, with flax fiber-reinforced alginate hydrogel, is developed. The study assesses the impact of flax fibers on 3D printing, mechanical, 4D printing, and geometric properties of the composite.
View article: Three-Dimensional Printable Enzymatically Active Plastics
Three-Dimensional Printable Enzymatically Active Plastics Open
Here, we describe a facile route to the synthesis of enzymatically active highly fabricable plastics, where the enzyme is an intrinsic component of the material. This is facilitated by the formation of an electrostatically stabilized enzym…
View article: Sequential Electrostatic Assembly of a Polymer Surfactant Corona Increases Activity of the Phosphotriesterase arPTE
Sequential Electrostatic Assembly of a Polymer Surfactant Corona Increases Activity of the Phosphotriesterase arPTE Open
We present a new methodology for the generation of discrete molecularly dispersed enzyme-polymer-surfactant bioconjugates. Significantly, we demonstrate that >3-fold increase in the catalytic efficiency of the diffusion-limited phosphotrie…