Graham P. Cook
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View article: Roles of GSK-3α and GSK-3β in T cell-mediated tumour rejection 3299
Roles of GSK-3α and GSK-3β in T cell-mediated tumour rejection 3299 Open
Description Glycogen synthase kinase-3 (GSK-3) has been shown as an upstream regulator of programmed cell death protein 1 (PD-1) and Lymphocyte activation gene-3 (LAG-3) gene expression in CD8 T cells and its inhibition can suppress tumour…
View article: Regulation of anti-tumour immunity by GSK-3; a potential target for immunotherapy 2732
Regulation of anti-tumour immunity by GSK-3; a potential target for immunotherapy 2732 Open
Description Immunotherapy has improved cancer treatment in recent decades, which harnesses the immune system to tackle cancer. However, not all cancer patients respond, nor does it cover all cancers, so alternative avenues are required. Gl…
View article: Oncolytic Maraba Virus MG1 Mediates Direct and Natural Killer Cell-Dependent Lysis of Ewing Sarcoma
Oncolytic Maraba Virus MG1 Mediates Direct and Natural Killer Cell-Dependent Lysis of Ewing Sarcoma Open
Background: Ewing sarcoma (EWS) is a rare cancer of the bone and soft tissue, most prevalent in children and young adults. The treatment of EWS has progressed relatively little in over 30 years. Survival rates for patients, particularly th…
View article: Phospho-enol pyruvate carboxykinase inhibition limits inflammatory T cell activation
Phospho-enol pyruvate carboxykinase inhibition limits inflammatory T cell activation Open
Following antigenic stimulation, T cells switch from a catabolic metabolic state maintained by low levels of nutrient uptake to an anabolic metabolism that sustains the biosynthetic and energetic demands of clonal expansion, differentiatio…
View article: Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma
Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma Open
Ewing sarcoma (EWS) is a rare cancer of the bone and soft tissue, most prevalent in children and young adults. Treatment of EWS has progressed relatively little in over 30 years. Survival rates for patients, particularly those with metasta…
View article: Corrigendum: Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment
Corrigendum: Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment Open
[This corrects the article DOI: 10.3389/fimmu.2024.1500570.].
View article: Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment
Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment Open
Background There has been limited success of cancer immunotherapies in the treatment of ovarian cancer (OvCa) to date, largely due to the immunosuppressive tumour microenvironment (TME). Tumour-associated macrophages (TAMs) are a major com…
View article: Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment
Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment Open
Background There has been limited success of cancer immunotherapies in the treatment of ovarian cancer (OvCa) to date, largely due to the immunosuppressive tumour microenvironment (TME). Tumour-associated macrophages (TAMs) are a major com…
View article: Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma
Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma Open
Peripheral blood transcriptomes from 383 patients with newly diagnosed melanoma were subjected to differential gene expression analysis. The hypotheses were that impaired systemic immunity is associated with poorer prognosis (thicker tumor…
View article: Immune subtyping of melanoma whole slide images using multiple instance learning
Immune subtyping of melanoma whole slide images using multiple instance learning Open
View article: Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition
Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition Open
CD146, also known as melanoma cell adhesion molecule (MCAM), is expressed in numerous cancers and has been implicated in the regulation of metastasis. We show that CD146 negatively regulates transendothelial migration (TEM) in breast cance…
View article: Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Gene lists per immune cell type after successive filtration steps.
View article: Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous m…
View article: Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
List of 70 genes shared between the signature used to generate the three immune subgroups in this study and the TCGA signature as well as tables of additional results from the analysis of the 3 immune subgroups: Genes and pathways upregula…
View article: Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Additional information on methods used and supplementary figures and tables. Figure S1: Schematic summary of consensus clustering; Figure S2: Comparison of the newly obtained immune subgroups with two published melanoma molecular signature…
View article: Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Gene lists per immune cell type after successive filtration steps.
View article: Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
List of 70 genes shared between the signature used to generate the three immune subgroups in this study and the TCGA signature as well as tables of additional results from the analysis of the 3 immune subgroups: Genes and pathways upregula…
View article: Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Additional information on methods used and supplementary figures and tables. Figure S1: Schematic summary of consensus clustering; Figure S2: Comparison of the newly obtained immune subgroups with two published melanoma molecular signature…
View article: Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous m…
View article: Editorial: Factors determining long term anti-tumor responses to immune checkpoint blockade therapy
Editorial: Factors determining long term anti-tumor responses to immune checkpoint blockade therapy Open
EDITORIAL article Front. Immunol., 21 December 2022Sec. Cancer Immunity and Immunotherapy Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.1120207
View article: Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition
Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition Open
CD146, also known as melanoma cell adhesion molecule (MCAM), is expressed in numerous cancers and has been implicated in the regulation of metastasis. We show that CD146 negatively regulates transendothelial migration (TEM) in breast cance…
View article: Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)
Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck) Open
View article: TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells
TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells Open
T cell activation is dependent upon the integration of antigenic, co-stimulatory and cytokine-derived signals and the availability and acquisition of nutrients from the environment. Furthermore, T cell activation is accompanied by reprogra…
View article: Corrigendum to “Corrigendum to ‘Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up’”
Corrigendum to “Corrigendum to ‘Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up’” Open
View article: Negative regulation of p53 by the poliovirus receptor PVR is a target of a human cytomegalovirus immune evasion molecule
Negative regulation of p53 by the poliovirus receptor PVR is a target of a human cytomegalovirus immune evasion molecule Open
Initially characterised for its role in maintaining genome integrity, p53 has emerged as a critical hub for coordinating cellular responses to diverse types of stress. Here we identify cell surface receptor loss as a signal for p53 inducti…
View article: Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase Lck
Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase Lck Open
The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell antigen receptor signalling to initiate adaptive immune responses. Despite many structure-function studies, the mode of action of Lck and the potential ro…
View article: TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8<sup>+</sup> T cells
TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8<sup>+</sup> T cells Open
T cell activation is dependent upon the integration of antigenic, costimulatory and cytokine-derived signals and the availability and acquisition of nutrients from the environment. Furthermore, T cell activation is accompanied by reprogram…
View article: Weakly-supervised learning for image-based classification of primary melanomas into genomic immune subgroups
Weakly-supervised learning for image-based classification of primary melanomas into genomic immune subgroups Open
Determining early-stage prognostic markers and stratifying patients for effective treatment are two key challenges for improving outcomes for melanoma patients. Previous studies have used tumour transcriptome data to stratify patients into…
View article: Oncolytic virus treatment differentially affects the CD56<sup>dim</sup> and CD56<sup>bright</sup> NK cell subsets in vivo and regulates a spectrum of human NK cell activity
Oncolytic virus treatment differentially affects the CD56<sup>dim</sup> and CD56<sup>bright</sup> NK cell subsets in vivo and regulates a spectrum of human NK cell activity Open
Natural killer (NK) cells protect against intracellular infection and cancer. These properties are exploited in oncolytic virus (OV) therapy, where antiviral responses enhance anti‐tumour immunity. We have analysed the mechanism by which r…
View article: Ulcerated melanoma: Systems biology evidence of inflammatory imbalance towards pro‐tumourigenicity
Ulcerated melanoma: Systems biology evidence of inflammatory imbalance towards pro‐tumourigenicity Open
Microscopic ulceration is an independent predictor of melanoma death. Here, we used systems biology to query the role of host and tumour‐specific processes in defining the phenotype. Albumin level as a measure of systemic inflammation was …