Graham Pawelec
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View article: Open problems in ageing science: a roadmap for biogerontology
Open problems in ageing science: a roadmap for biogerontology Open
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These …
View article: Clinical data-driven classification of pre-frailty reveals sex-specific patterns – Data from the Berlin Aging Study II (BASE-II)
Clinical data-driven classification of pre-frailty reveals sex-specific patterns – Data from the Berlin Aging Study II (BASE-II) Open
Frailty is a geriatric condition with multidimensional consequences that strongly affect older adults' quality of life. The lack of a universal standard to describe, diagnose, and treat frailty further complicates this situation. Nowadays,…
View article: Open problems in ageing science: A roadmap for biogerontology
Open problems in ageing science: A roadmap for biogerontology Open
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These …
View article: Antigen-specific peripheral immune cell dynamics predicting clinical responses to checkpoint blockade in melanoma
Antigen-specific peripheral immune cell dynamics predicting clinical responses to checkpoint blockade in melanoma Open
Many years ago, we hypothesized that melanoma patients possessing T cells reacting to cancer antigens would do better than those who did not. To test this, we cultured PBMC from conventionally-treated metastatic melanoma patients with shor…
View article: Frequencies of Circulating Immune Cells in Patients with Parkinson’s Disease: Correlation with MDS-UPDRS Scores
Frequencies of Circulating Immune Cells in Patients with Parkinson’s Disease: Correlation with MDS-UPDRS Scores Open
Background: Parkinson’s Disease (PD) is associated with dysregulated/chronic inflammation. The immune system has multiple roles including beneficial effects such as clearing alpha synuclein aggregates. However, peripheral immune cells ente…
View article: Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease
Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease Open
The immune system plays a crucial role in the pathogenesis of neurodegenerative diseases. Here, we explored whether blood immune cell profiles are already altered in healthy individuals with a genetic predisposition to amyotrophic lateral …
View article: The Importance of Monitoring Antigen-Specific Memory B Cells, and How ImmunoSpot Assays Are Suitable for This Task
The Importance of Monitoring Antigen-Specific Memory B Cells, and How ImmunoSpot Assays Are Suitable for This Task Open
Determining an individual’s humoral immune reactivity to a pathogen, autoantigen, or environmental agent is traditionally accomplished through the assessment of specific antibody levels in blood. However, in many instances, titers of speci…
View article: Immune Cell Distributions in the Blood of Healthy Individuals at High Genetic Risk of Parkinson’s Disease
Immune Cell Distributions in the Blood of Healthy Individuals at High Genetic Risk of Parkinson’s Disease Open
The immune system likely plays a key role in Parkinson’s disease (PD) pathophysiology. Thus, we investigated whether immune cell compositions are already altered in healthy individuals at high genetic risk for PD. We quantified 92 immune c…
View article: Information That Cannot Be Gained by Studies of Serum Antibodies: ImmunoSpot Assays Permit Detailed Assessment of Antigen-Specific Memory B Cells Through Defining Their Frequency, Affinity, Cross-Reactivity Profile, and Antibody Class/Subclass Utilization
Information That Cannot Be Gained by Studies of Serum Antibodies: ImmunoSpot Assays Permit Detailed Assessment of Antigen-Specific Memory B Cells Through Defining Their Frequency, Affinity, Cross-Reactivity Profile, and Antibody Class/Subclass Utilization Open
Determining an individual’s humoral immune reactivity to a pathogen, autoantigen, or environmental agent is traditionally accomplished through assessment of specific antibody levels in blood. However, in many instances, titers of specific …
View article: Peripheral immune profiles in individuals at genetic risk for amyotrophic lateral sclerosis and Alzheimer’s disease
Peripheral immune profiles in individuals at genetic risk for amyotrophic lateral sclerosis and Alzheimer’s disease Open
The immune system plays a crucial role in the pathogenesis of neurodegenerative diseases. Here, we explored whether blood immune cell profiles are already altered in healthy individuals with a genetic predisposition to amyotrophic lateral …
View article: Immune cell distributions in the blood of healthy individuals at high genetic risk of Parkinson’s disease
Immune cell distributions in the blood of healthy individuals at high genetic risk of Parkinson’s disease Open
The immune system likely plays a key role in Parkinson’s disease (PD) pathophysiology. Thus, we investigated whether immune cell compositions are already altered in healthy individuals at high genetic risk for PD. We quantified 92 immune c…
View article: Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID
Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID Open
The immune system plays a crucial role in many human diseases. In this context, genome-wide association studies (GWAS) offer valuable insights to elucidate the role of immunity in health and disease. The present multi-omics study aimed to …
View article: No increase of CD8+ TEMRA cells in the blood of healthy adults at high genetic risk of Alzheimer's disease
No increase of CD8+ TEMRA cells in the blood of healthy adults at high genetic risk of Alzheimer's disease Open
The adaptive immune system plays a crucial role in the pathophysiology and progression of Alzheimer's disease (AD).1 In this context, we read with great interest the recent publication by Gericke et al.,2 who reported a positive associatio…
View article: Frequencies of activated T cell populations increase in breast milk of HCMV-seropositive mothers during local HCMV reactivation
Frequencies of activated T cell populations increase in breast milk of HCMV-seropositive mothers during local HCMV reactivation Open
Background Human cytomegalovirus (HCMV) can reactivate in the mammary gland during lactation and is shed into breast milk of nearly every HCMV-IgG-seropositive mother of a preterm infant. Dynamics of breast milk leukocytes during lactation…
View article: The Updated Scope of the Journal of Ageing and Longevity
The Updated Scope of the Journal of Ageing and Longevity Open
We are happy that the Journal of Ageing and Longevity has now entered its third year, publishing notable papers covering the wide field encompassed by its title [...]
View article: Putative Cancer Stem Cell Markers are Frequently Expressed by Melanoma Cells in Vitro and in Situ but are also Present in Benign Differentiated Cells
Putative Cancer Stem Cell Markers are Frequently Expressed by Melanoma Cells in Vitro and in Situ but are also Present in Benign Differentiated Cells Open
Background: Currently, there remains an incomplete view of cancer stem cells (CSCs) in solid tumours. Methods: We studied a panel of putative CSC surface markers (ALDH1A1, ABCG2, CD44v7/8, CD44v10, CD133, CD271, and Nestin) in 40 establish…
View article: Early decrease of blood myeloid-derived suppressor cells during checkpoint inhibition is a favorable biomarker in metastatic melanoma
Early decrease of blood myeloid-derived suppressor cells during checkpoint inhibition is a favorable biomarker in metastatic melanoma Open
Background The need for reliable clinical biomarkers to predict which patients with melanoma will benefit from immune checkpoint blockade (ICB) remains unmet. Several different parameters have been considered in the past, including routine…
View article: Here, There, and Everywhere: Myeloid-Derived Suppressor Cells in Immunology
Here, There, and Everywhere: Myeloid-Derived Suppressor Cells in Immunology Open
Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with cancer where they profoundly suppress T cell– and NK cell–mediated antitumor immunity. Inflammation is a central feature of many pathologies and nor…
View article: Supplementary Table 2 from Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19–IL2 Results in Sustained Clinical and Systemic Immunologic Responses
Supplementary Table 2 from Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19–IL2 Results in Sustained Clinical and Systemic Immunologic Responses Open
XLSX file - 82K, Change in frequency of cytokine-releasing T cells at different time points.
View article: Supplementary Figure 2 from Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19–IL2 Results in Sustained Clinical and Systemic Immunologic Responses
Supplementary Figure 2 from Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19–IL2 Results in Sustained Clinical and Systemic Immunologic Responses Open
PDF file - 870K, Detailed gating strategy of all the analyzed immune cell subsets.
View article: Supplementary Table 4 from Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14<sup>ARF</sup> and RARβ Signaling
Supplementary Table 4 from Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14<sup>ARF</sup> and RARβ Signaling Open
PDF file - 51K, Promoter hypermethylation events.
View article: Supplementary Table 2 from Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14<sup>ARF</sup> and RARβ Signaling
Supplementary Table 2 from Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14<sup>ARF</sup> and RARβ Signaling Open
PDF file - 69K, Mutation details.
View article: Supplementary Table 3 from Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14<sup>ARF</sup> and RARβ Signaling
Supplementary Table 3 from Mutual Exclusivity Analysis of Genetic and Epigenetic Drivers in Melanoma Identifies a Link Between p14<sup>ARF</sup> and RARβ Signaling Open
PDF file - 43K, Copy number gains.