Michael Granato
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View article: Serotonin neuromodulation directs optic nerve regeneration
Serotonin neuromodulation directs optic nerve regeneration Open
Optic nerve (ON) regeneration in mammalian systems is limited by an overshadowing dominance of inhibitory factors. This has severely hampered the identification of pro-regenerative pathways. Here, we take advantage of the regenerative capa…
View article: Temporally and Functionally Distinct Contributions to Value Based Choice Along the Anterior-Posterior Dorsomedial Striatal Axis
Temporally and Functionally Distinct Contributions to Value Based Choice Along the Anterior-Posterior Dorsomedial Striatal Axis Open
While the dorsoventral and mediolateral organization of striatum has resolved clear functional distinctions, far less is known about how the anterior-posterior striatal axis contributes to behavioral control. We explore this within the dor…
View article: Loss of DOT1L disrupts neuronal transcription, behavior, and leads to a neurodevelopmental disorder
Loss of DOT1L disrupts neuronal transcription, behavior, and leads to a neurodevelopmental disorder Open
Individuals with monoallelic gain-of-function variants in the histone lysine methyltransferase DOT1L display global developmental delay and varying congenital anomalies. However, the impact of monoallelic loss of DOT1L remains unclear. Her…
View article: Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit
Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit Open
In the developing brain, groups of neurons organize into functional circuits that direct diverse behaviors. One such behavior is the evolutionarily conserved acoustic startle response, which in zebrafish is mediated by a well-defined hindb…
View article: A glial cell derived pathway directs regenerating optic nerve axons toward the optic chiasm
A glial cell derived pathway directs regenerating optic nerve axons toward the optic chiasm Open
After optic nerve injury, several retinal ganglion cell (RGC) intrinsic signaling pathways have been shown to enhance RGC survival and RGC axonal growth. In contrast, few extrinsic cues have been identified that guide regenerating RGC axon…
View article: Serotonin neuromodulation directs optic nerve regeneration
Serotonin neuromodulation directs optic nerve regeneration Open
Optic nerve (ON) regeneration in mammalian systems is limited by an overshadowing dominance of inhibitory factors. This has severely hampered the identification of pro- regenerative pathways. Here, we take advantage of the regenerative cap…
View article: A single base pair substitution in zebrafish distinguishes between innate and acute startle behavior regulation
A single base pair substitution in zebrafish distinguishes between innate and acute startle behavior regulation Open
Behavioral thresholds define the lowest stimulus intensities sufficient to elicit a behavioral response. Establishment of baseline behavioral thresholds during development is critical for proper responses throughout the animal’s life. Desp…
View article: Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit
Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit Open
In the developing brain, groups of neurons organize into functional circuits that direct diverse behaviors. One such behavior is the evolutionarily conserved acoustic startle response, which in zebrafish is mediated by a well-defined hindb…
View article: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Functional and pharmacological analyses of visual habituation learning in larval zebrafish Open
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms, we took ad…
View article: A single base pair substitution on Chromosome 25 in zebrafish distinguishes between development and acute regulation of behavioral thresholds
A single base pair substitution on Chromosome 25 in zebrafish distinguishes between development and acute regulation of behavioral thresholds Open
Behavioral thresholds define the lowest stimulus intensities sufficient to elicit a behavioral response. Establishment of baseline behavioral thresholds during development is critical for proper responses throughout the animal’s life. Desp…
View article: Author Response: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Author Response: Functional and pharmacological analyses of visual habituation learning in larval zebrafish Open
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms we took adv…
View article: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Functional and pharmacological analyses of visual habituation learning in larval zebrafish Open
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms we took adv…
View article: Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus
Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus Open
A critical step for functional recovery from peripheral nerve injury is for regenerating axons to connect with their pre-injury targets. Reestablishing pre-injury target specificity is particularly challenging for limb-innervating axons as…
View article: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Functional and pharmacological analyses of visual habituation learning in larval zebrafish Open
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms, we took ad…
View article: Inhibition drives habituation of a larval zebrafish visual response
Inhibition drives habituation of a larval zebrafish visual response Open
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms we took adv…
View article: Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity
Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity Open
Habituation is a foundational learning process critical for animals to adapt their behavior to changes in their sensory environment. Although habituation is considered a simple form of learning, the identification of a multitude of molecul…
View article: Multivariate analysis of variegated expression in Neurons: A strategy for unbiased localization of gene function to candidate brain regions in larval zebrafish
Multivariate analysis of variegated expression in Neurons: A strategy for unbiased localization of gene function to candidate brain regions in larval zebrafish Open
Behavioral screens in model organisms have greatly facilitated the identification of genes and genetic pathways that regulate defined behaviors. Identifying the neural circuitry via which specific genes function to modify behavior remains …
View article: A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration
A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration Open
A critical step for functional recovery from peripheral nerve injury is for regenerating axons to connect with their pre-injury targets. Reestablishing pre-injury target specificity is particularly challenging for limb-innervating axons as…
View article: Mitochondrial genes in the 22q11.2 deleted region regulate neural stem and progenitor cell proliferation
Mitochondrial genes in the 22q11.2 deleted region regulate neural stem and progenitor cell proliferation Open
Summary Microdeletion of a 3Mbp region encompassing 45 protein-coding genes at chromosome 22q11.2 (22q11.2DS) predisposes to multiple neurodevelopmental disorders and is one of the greatest genetic risk factors for schizophrenia. Defective…
View article: The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons
The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons Open
Decision making is a fundamental nervous system function that ranges widely in complexity and speed of execution. We previously established larval zebrafish as a model for sensorimotor decision making and identified the G-protein-coupled c…
View article: cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold
cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold Open
Background The ability to filter sensory information into relevant versus irrelevant stimuli is a fundamental, conserved property of the central nervous system and is accomplished in part through habituation learning. Synaptic plasticity t…
View article: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Functional and pharmacological analyses of visual habituation learning in larval zebrafish Open
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms we took adv…
View article: Zebrafish behavior as a gateway to nervous system assembly and plasticity
Zebrafish behavior as a gateway to nervous system assembly and plasticity Open
Nervous system assembly relies on a diversity of cellular processes ranging from dramatic tissue reorganization to local, subcellular changes all driven by precise molecular programs. Combined, these processes culminate in an animal's abil…
View article: Pharmacogenetic and whole-brain activity analyses uncover integration of distinct molecular and circuit programs that drive learning
Pharmacogenetic and whole-brain activity analyses uncover integration of distinct molecular and circuit programs that drive learning Open
Habituation is a foundational learning process critical for animals to adapt their behavior to changes in their sensory environment. Although habituation is considered a simple form of learning, the identification of a multitude of molecul…
View article: <i>cacna2d3</i>, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold
<i>cacna2d3</i>, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold Open
The ability to filter sensory information into relevant versus irrelevant stimuli is a fundamental, conserved property of the central nervous system and is accomplished in part through habituation learning. Synaptic plasticity that underli…
View article: Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle
Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle Open
The receptor tyrosine kinase MuSK, its co-receptor Lrp4 and the Agrin ligand constitute a signaling pathway that is crucial in axial muscle for neuromuscular synapse development, yet whether this pathway functions similarly in appendicular…
View article: CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish
CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish Open
Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, because of t…