Grant A. McGregor
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View article: Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer Open
Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR-proficient PC and after platinum therapy.
View article: HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer Open
View article: Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer Open
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. We interrogated the transcriptome, genome, proteome and funct…
View article: <i>HNF4A</i> and <i>GATA6</i> Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
<i>HNF4A</i> and <i>GATA6</i> Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer Open
View article: Investigation into the role of the SMC5/6 Complex in human cells
Investigation into the role of the SMC5/6 Complex in human cells Open
The Structural Maintenance of Chromosome (SMC) family of proteins are required to regulate almost all aspects of chromosome biology and are critical for genomic stability. The SMC5/6 complex, a member of this family, is composed of two SMC…
View article: Specialized interfaces of Smc5/6 control hinge stability and DNA association
Specialized interfaces of Smc5/6 control hinge stability and DNA association Open
View article: Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease
Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease Open
The structural maintenance of chromosomes (SMC) family of proteins supports mitotic proliferation, meiosis, and DNA repair to control genomic stability. Impairments in chromosome maintenance are linked to rare chromosome breakage disorders…