Gregory W. Albers
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View article: Prolonged Venous Transit on Perfusion Imaging: An Evolving Marker of Outcomes in Large Vessel Occlusion Stroke – A Comprehensive Review
Prolonged Venous Transit on Perfusion Imaging: An Evolving Marker of Outcomes in Large Vessel Occlusion Stroke – A Comprehensive Review Open
Stroke remains a leading cause of death and disability worldwide, with anterior circulation large-vessel occlusion (AIS-LVO) representing a major contributor. While arterial parameters such as cerebral blood flow (CBF), cerebral blood volu…
View article: Neuroimaging Predictors of Futile Recanalization in Anterior Circulation Stroke: A Systematic Review and Meta-Analysis
Neuroimaging Predictors of Futile Recanalization in Anterior Circulation Stroke: A Systematic Review and Meta-Analysis Open
AIS: Acute Ischemic Stroke; CCR: Cerebral Collateral Recycle; EVT: Endovascular Thrombectomy; FR: Futile Recanalization; HIR: Hypoperfusion Intensity Ratio; LVO: Large Vessel Occlusion; MT: Mechanical Thrombectomy; rCBV: Relative Cerebral …
View article: Cerebral Blood Volume Index Is Associated with Futile Recanalization After Endovascular Thrombectomy in Anterior Circulation Large Vessel Occlusion Stroke
Cerebral Blood Volume Index Is Associated with Futile Recanalization After Endovascular Thrombectomy in Anterior Circulation Large Vessel Occlusion Stroke Open
EVT＝ Endovascular Thrombectomy; LVO＝ Large Vessel Occlusion; AIS＝ Acute Ischemic Stroke; HIR＝Hypoperfusion Intensity Ratio; ROC＝ Receiver Operating Characteristic; AUC＝ Area Under the Curve; HT＝ Hemorrhagic Transformation; Tmax＝ Time-to-Ma…
View article: Both Infarcted and Noninfarcted Brain Regions Contribute to Deep Learning–Based MRI Prediction of Acute Stroke Outcome
Both Infarcted and Noninfarcted Brain Regions Contribute to Deep Learning–Based MRI Prediction of Acute Stroke Outcome Open
While the best performance came from by using the full brain imaging volume, we demonstrate that the infarct location, its signal characteristics, and importantly, the noninfarcted regions all contribute to the predictions. The noninfarcte…
View article: Prolonged Venous Transit Is Associated with Unfavorable Functional Outcomes in Large Core Stroke
Prolonged Venous Transit Is Associated with Unfavorable Functional Outcomes in Large Core Stroke Open
PVT is independently associated with unfavorable outcomes in patients with large core AIS-LVO. These findings suggest PVT may serve as a prognostic marker, warranting further investigation and validation in larger prospective studies to gu…
View article: Artificial Intelligence and Novel Trial Designs for Acute Ischemic Stroke: Opportunities and Challenges
Artificial Intelligence and Novel Trial Designs for Acute Ischemic Stroke: Opportunities and Challenges Open
The Stroke Treatment Academic Industry Roundtable convened a workshop regarding artificial intelligence (AI) and innovative clinical trial designs during the Stroke Treatment Academic Industry Roundtable XIII meeting on March 28, 2025. Thi…
View article: Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion
Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion Open
BACKGROUND Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging‐based inclusion criteria, whereas many successful large vessel occlusion (LVO) E…
View article: Unfavorable Perfusion Collateral Impairment Score Is Associated with Higher Odds of Poor Outcomes in Large Vessel Occlusion Stroke
Unfavorable Perfusion Collateral Impairment Score Is Associated with Higher Odds of Poor Outcomes in Large Vessel Occlusion Stroke Open
BACKGROUND Effective collateral circulation significantly influences clinical outcomes in patients with acute ischemic stroke due to large vessel occlusion. We developed and evaluated a composite Perfusion Collateral Impairment Score (PCIS…
View article: Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke
Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke Open
Background and Purpose Distal medium‐vessel occlusion (DMVO) strokes represent a significant proportion of acute ischemic stroke cases, yet optimal management remains unclear. Prolonged venous transit (PVT), a marker of poor venous outflow…
View article: Demographic and Premorbid Clinical Factors Predict Modified Rankin Score in Large and Medium Vessel Occlusion Ischemic Strokes
Demographic and Premorbid Clinical Factors Predict Modified Rankin Score in Large and Medium Vessel Occlusion Ischemic Strokes Open
Background/Objectives: We report on the association of clinical, demographic, and peri- and intraoperative factors with patient outcomes in large- and, separately, medium-vessel acute ischemic stroke (AIS) occlusions treated with mechanica…
View article: Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke
Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke Open
Qualitative PVT assessment demonstrated substantial interobserver and almost perfect intraobserver reliability. These findings support the use of PVT as a consistent marker of impaired venous outflow in AIS-LVO. Future studies should explo…
View article: Tenecteplase versus alteplase in patients with acute ischemic stroke: an updated systematic review and meta-analysis
Tenecteplase versus alteplase in patients with acute ischemic stroke: an updated systematic review and meta-analysis Open
Background Stroke was the second leading cause of death and the third leading cause of disability worldwide in 2019. Alteplase is an FDA-approved medication for the treatment of patients with ischemic stroke within 4.5 h. However, Tenectep…
View article: Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke
Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke Open
Arterial inflow restoration and collateral status have been significantly correlated with functional outcomes in AIS-LVO patients undergoing mechanical thrombectomy (MT). CT perfusion imaging biomarkers, including prolonged venous transit …
View article: Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome
Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome Open
Background: Patients with acute ischemic stroke with a large vessel occlusion (AIS-LVO) admitted to primary stroke centers (PSC) often require inter-hospital transfer to a comprehensive stroke center (CSC) for endovascular therapy (EVT). W…
View article: Intravenous Thrombolysis Use before Inter‐Facility Transfer for Thrombectomy: Association with Efficacy and Safety Outcomes
Intravenous Thrombolysis Use before Inter‐Facility Transfer for Thrombectomy: Association with Efficacy and Safety Outcomes Open
Objective Patients with acute ischemic stroke and large vessel occlusion (LVO) often require transfer from primary stroke centers (PSCs) to thrombectomy‐capable centers. This study assessed the efficacy and safety of intravenous thrombolys…
View article: The relative cerebral blood volume (rCBV) <42% is independently associated with prolonged hospitalization in anterior circulation large vessel occlusion
The relative cerebral blood volume (rCBV) <42% is independently associated with prolonged hospitalization in anterior circulation large vessel occlusion Open
Background The pretreatment rCBV <42% lesion volume on CT Perfusion (CTP) has recently been shown to predict 90-day functional outcomes in stroke patients. However, its association with length of stay (LOS) has not yet been explored. This …
View article: Impact of Helicopter Transfer on Recanalization and Outcomes in Anterior Large Vessel Occlusion Strokes
Impact of Helicopter Transfer on Recanalization and Outcomes in Anterior Large Vessel Occlusion Strokes Open
BACKGROUND: For patients with acute ischemic stroke due to a large vessel occlusion admitted in primary stroke centers, helicopter transfer to comprehensive stroke centers is often used to expedite access to mechanical thrombectomy. Some s…
View article: The Cortical Vein Opacification Score Is Independently Associated with Good and Excellent Functional Outcomes at 90 Days in Patients with Minor Stroke with Anterior Circulation Large-Vessel Occlusion: A Multicenter Study
The Cortical Vein Opacification Score Is Independently Associated with Good and Excellent Functional Outcomes at 90 Days in Patients with Minor Stroke with Anterior Circulation Large-Vessel Occlusion: A Multicenter Study Open
Our analysis demonstrates that COVES is independently associated with good and excellent functional outcomes at 90 days in cases of minor AIS-LVO. Further prospective studies are needed to better understand the role of COVES in determining…
View article: Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio
Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio Open
Background Collateral status plays a crucial role in outcomes after acute ischemic stroke due to large vessel occlusion. Tissue‐level collaterals and venous outflow are key components following mechanical thrombectomy. This study evaluates…
View article: Redefining ischemic core, penumbra, and target mismatch on CT perfusion in acute anterior distal medium vessel occlusion
Redefining ischemic core, penumbra, and target mismatch on CT perfusion in acute anterior distal medium vessel occlusion Open
Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO) E…
View article: Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke
Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke Open
Importance After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke is not well-known. Objective To determine the annual incidence rates and cumulative incidences of stroke up to 10 years after TIA or minor str…
View article: Underestimation of Follow-Up Infarct Volume by Acute CT Perfusion Imaging
Underestimation of Follow-Up Infarct Volume by Acute CT Perfusion Imaging Open
Underestimation of follow-up infarct by CTP is substantial and the follow-up infarct can partially be detected by baseline NCCT, especially in patients with stroke with delayed presentation. Combining rNCCT>5% and CTP increases the accurac…
View article: Hypoperfusion Intensity Ratio Less Than 0.4 Is Associated with Favorable Outcomes in Unsuccessfully Reperfused Acute Ischemic Stroke with Large-Vessel Occlusion
Hypoperfusion Intensity Ratio Less Than 0.4 Is Associated with Favorable Outcomes in Unsuccessfully Reperfused Acute Ischemic Stroke with Large-Vessel Occlusion Open
In unsuccessfully reperfused patients with AIS-LVO, an HIR of <0.4 is associated with favorable outcomes, emphasizing on the importance of robust collateral circulation. This finding suggests that perfusion imaging and HIR evaluation could…
View article: Methylprednisolone as Adjunct to Thrombectomy for Acute Intracranial Internal Carotid Artery Occlusion Stroke
Methylprednisolone as Adjunct to Thrombectomy for Acute Intracranial Internal Carotid Artery Occlusion Stroke Open
Importance Patients with acute ischemic stroke (AIS) due to intracranial internal carotid artery (ICA) occlusion often have poor functional outcomes despite undergoing endovascular thrombectomy (EVT). Objective To investigate the effective…
View article: Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion
Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion Open
Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outc…
View article: The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion
The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion Open
Background Pretreatment CT perfusion (CTP) marker relative cerebral blood volume (rCBV) < 42% lesion volume has recently shown to predict poor collateral status and poor 90-day functional outcome. However, there is a paucity of studies ass…
View article: Role and Prognostic Implications of Venous Outflow Assessment in Acute Ischemic Stroke
Role and Prognostic Implications of Venous Outflow Assessment in Acute Ischemic Stroke Open
Introduction The venous outflow profile (VOP) is a crucial yet often overlooked aspect affecting stroke outcomes. It plays a major role in the physiopathology of acute cerebral ischemia, as it accounts for both the upstream arterial collat…
View article: Hypoperfusion intensity ratio to differentiate between stroke etiologies in patients with a large vessel occlusion
Hypoperfusion intensity ratio to differentiate between stroke etiologies in patients with a large vessel occlusion Open
Background: Collateral circulation plays a key role in acute ischemic stroke. We sought to determine the association between the arterial collateral status, estimated by the Hypoperfusion Intensity Ratio (HIR) on perfusion MRI, and stroke …