Grant T. Liu
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View article: QLTI-02. Management of adverse events occurring with MAPK-directed therapies in patients with pediatric low-grade glioma: Recommendations from an expert Delphi consensus initiative
QLTI-02. Management of adverse events occurring with MAPK-directed therapies in patients with pediatric low-grade glioma: Recommendations from an expert Delphi consensus initiative Open
BACKGROUND Pediatric low-grade gliomas (pLGGs) can become a chronic disease requiring multiple courses of therapy. Emerging mitogen-activated protein kinase (MAPK) inhibitors (MAPKi) are targeted therapies that are effective in patients wi…
View article: Larger tumor volume is associated with visual acuity loss and axonal degeneration in children with optic pathway gliomas secondary to neurofibromatosis type 1
Larger tumor volume is associated with visual acuity loss and axonal degeneration in children with optic pathway gliomas secondary to neurofibromatosis type 1 Open
Background We investigated whether volumetric magnetic resonance imaging (MRI) measures of the anterior visual pathway (AVP) in optic pathway gliomas secondary to Neurofibromatosis type 1 (NF1−OPG) are associated with visual acuity (VA) lo…
View article: Different Characteristics of Pre-Pubertal and Post-Pubertal Idiopathic Intracranial Hypertension: A Narrative Review
Different Characteristics of Pre-Pubertal and Post-Pubertal Idiopathic Intracranial Hypertension: A Narrative Review Open
Idiopathic intracranial hypertension (IIH) affects both children and adults. There are currently no clinical trials in IIH for those who are adolescents or children. The aims of this narrative review were to characterise the differences be…
View article: The Pediatric Optic Neuritis Prospective Outcomes Study
The Pediatric Optic Neuritis Prospective Outcomes Study Open
View article: Comparison of Visual Acuity Results Between ATS-HOTV and E-ETDRS Testing Methods in Children With Optic Pathway Gliomas
Comparison of Visual Acuity Results Between ATS-HOTV and E-ETDRS Testing Methods in Children With Optic Pathway Gliomas Open
It is imperative that age-appropriate VA testing methods are standardized across all pediatric OPG clinical trials.
View article: MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study
MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study Open
This study examines the association of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disorder with pediatric optic neuritis to guide prognosis and treatment.
View article: NFB-09. ENROLLMENT AND CLINICAL CHARACTERISTICS OF NEWLY DIAGNOSED, NEUROFIBROMATOSIS TYPE 1 ASSOCIATED OPTIC PATHWAY GLIOMA (NF1-OPG): PRELIMINARY RESULTS FROM AN INTERNATIONAL MULTI-CENTER NATURAL HISTORY STUDY
NFB-09. ENROLLMENT AND CLINICAL CHARACTERISTICS OF NEWLY DIAGNOSED, NEUROFIBROMATOSIS TYPE 1 ASSOCIATED OPTIC PATHWAY GLIOMA (NF1-OPG): PRELIMINARY RESULTS FROM AN INTERNATIONAL MULTI-CENTER NATURAL HISTORY STUDY Open
INTRODUCTION Because treatment and clinical management decisions for children with NF1-OPG remain challenging, we sought to establish evidence-based guidelines. We prospectively enrolled children with newly-diagnosed NF1-OPGs, and gathered…
View article: Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study
Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study Open
Background: Prospective and longitudinal studies assessing the utility of spectral-domain optical coherence tomography (SD-OCT) to differentiate papilledema from pseudopapilledema are lacking. We studied the sensitivity and specificity of …
View article: High- and Low-Contrast Letter Acuity Perception Matures With Age in Normally Sighted Children
High- and Low-Contrast Letter Acuity Perception Matures With Age in Normally Sighted Children Open
Background: High-contrast visual acuity (HCVA) changes with age, yet little is known about pediatric-specific age- and sex-normative values for low-contrast letter acuity (LCLA). We define maturational changes in monocular and binocular HC…
View article: Outcomes After Transcervical Thymectomy for Ocular Myasthenia Gravis: A Retrospective Cohort Study With Inverse Probability Weighting
Outcomes After Transcervical Thymectomy for Ocular Myasthenia Gravis: A Retrospective Cohort Study With Inverse Probability Weighting Open
Background: The benefit of thymectomy in reducing requirement for corticosteroids, symptom severity, need for immunosuppression, and hospitalization rates in patients with seropositive generalized myasthenia has recently been established. …
View article: Headache Characteristics in Children With Pseudotumor Cerebri Syndrome, Elevated Opening Pressure Without Papilledema, and Normal Opening Pressure: A Retrospective Cohort Study
Headache Characteristics in Children With Pseudotumor Cerebri Syndrome, Elevated Opening Pressure Without Papilledema, and Normal Opening Pressure: A Retrospective Cohort Study Open
Background Certain headache characteristics and associated symptoms are commonly attributed to increased intracranial pressure, but they have not been systematically studied among children in the context of revised diagnostic criteria for …
View article: Retrospective, Multicenter Comparison of the Clinical Presentation of Patients Presenting With Diplopia From Giant Cell Arteritis vs Other Causes
Retrospective, Multicenter Comparison of the Clinical Presentation of Patients Presenting With Diplopia From Giant Cell Arteritis vs Other Causes Open
Background: Although giant cell arteritis (GCA) is a well-known cause of transient and permanent vision loss, diplopia as a presenting symptom of this condition is uncommon. We compared symptoms and signs of patients presenting with diplop…
View article: Clinical and Prognostic Significance of Cerebrospinal Fluid Opening and Closing Pressures in Pediatric Pseudotumor Cerebri Syndrome
Clinical and Prognostic Significance of Cerebrospinal Fluid Opening and Closing Pressures in Pediatric Pseudotumor Cerebri Syndrome Open
View article: Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision
Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision Open
Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1), leading to visual deficits in fewer than half of these individuals. The goal of chemotherapy is to preserve vision, but vision loss in NF1-assoc…
View article: Pediatric Optic Neuritis: What Is New
Pediatric Optic Neuritis: What Is New Open
Few diseases blur the margins between their childhood and adult-onset varieties as much as optic neuritis. This report will review our state of knowledge of pediatric optic neuritis, as well as its relationship to the latest consensus defi…
View article: Optical coherence tomography and visual evoked potentials in pediatric MS
Optical coherence tomography and visual evoked potentials in pediatric MS Open
OCT and pVEPs provide complementary but distinct insights. OCT is sensitive to retinal changes in the context of clinical ON, whereas pVEPs are useful to detect disseminated lesions of the visual pathway in children with MS.
View article: Evaluation of Optical Coherence Tomography to Detect Elevated Intracranial Pressure in Children
Evaluation of Optical Coherence Tomography to Detect Elevated Intracranial Pressure in Children Open
Noninvasive quantitative measures of the peripapillary retinal structure by SD-OCT were correlated with invasively measured intracranial pressure. Optical coherence tomographic parameters showed promise as surrogate, noninvasive measures o…
View article: Clinical Reasoning: A 59-year-old man with multifocal strokes, then subsequent painful eye movements and diplopia
Clinical Reasoning: A 59-year-old man with multifocal strokes, then subsequent painful eye movements and diplopia Open
Reasoning:A 59-year-old man with multifocal strokes, then subsequent painful eye movements and diplopia SECTION 1A 59-year-old man, who was a nonsmoker, with persistent hematuria and history of multifocal strokes was admitted for progressi…
View article: Orbital/Periorbital Plexiform Neurofibromas in Children with Neurofibromatosis Type 1
Orbital/Periorbital Plexiform Neurofibromas in Children with Neurofibromatosis Type 1 Open
View article: A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation of <i> <scp>KIF</scp> 2A </i>
A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation of <i> <span>KIF</span> 2A </i> Open
Findings support the pathogenic link between KIF2A mutation and lissencephaly, and expand the range of presentation to include infantile spasms and congenital anomalies.
View article: Binocular low-contrast letter acuity and the symbol digit modalities test improve the ability of the Multiple Sclerosis Functional Composite to predict disease in pediatric multiple sclerosis
Binocular low-contrast letter acuity and the symbol digit modalities test improve the ability of the Multiple Sclerosis Functional Composite to predict disease in pediatric multiple sclerosis Open
View article: Pediatric Optic Neuritis Prospective Outcomes Study
Pediatric Optic Neuritis Prospective Outcomes Study Open
Optic neuritis (ON) is a well-studied disorder of the optic nerve in adults (1). The Optic Neuritis Treatment Trial (ONTT) is one of the most widely cited clinical trials in ophthalmology and provided invaluable knowledge regarding the eti…
View article: Editor’s Focus
Editor’s Focus Open
View article: Elevated Cerebrospinal Fluid Opening Pressure in a Pediatric Demyelinating Disease Cohort
Elevated Cerebrospinal Fluid Opening Pressure in a Pediatric Demyelinating Disease Cohort Open