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Contemporary surgical strategies for pediatric laryngotracheal stenosis: a comprehensive review Open
Background Pediatric laryngotracheal stenosis (LTS) presents a complex and heterogeneous clinical challenge, requiring individualized surgical approaches to restore airway patency and function. Depending on stenosis severity, anatomical si…
From Clinic to Real Life: Speech-Language Therapists' Perspectives on Extratherapy Generalization in Children With Cleft Palate Open
Purpose: Extratherapy generalization, defined as the transfer of sounds learned in the training environment to spontaneous speech outside the clinical setting, is a crucial yet underexplored facet of speech therapy in children with a cleft…
Correction: Histological analysis of the medial gastrocnemius muscle in young healthy children Open
[This corrects the article DOI: 10.3389/fphys.2024.1336283.].
Protocol for a Qualitative Study on the Acceptability of High‐ and Low‐Intensity Speech Intervention in Children With Cleft Palate: Perceptions of Children, Their Caregivers and Speech–Language Pathologists Open
Background Traditional low‐intensity speech therapy in children with cleft palate with or without cleft lip (CP ± L), provided twice weekly for 30 min over months or even years, lacks solid scientific evidence and may lead to poor outcomes…
View article: Learnability of the LAHSHAL Classification for Oral Clefts: Results of an International Webinar
Learnability of the LAHSHAL Classification for Oral Clefts: Results of an International Webinar Open
Introduction: Orofacial clefts are common congenital anomalies with significant physical, emotional, and social challenges. Classification systems like LAHSHAL aim to standardize cleft descriptions, enhancing clinical communication and res…
Partial cricotracheal resection for treatment of subglottic stenosis: complications and outcomes Open
Purpose Subglottic stenosis (SGS) is defined as an obstruction of the subglottic area, potentially extending towards the first tracheal rings. Although endoscopic procedures are frequently preferred as first-line treatment, (partial) crico…
View article: Between unity and disparity: current treatment protocols for common orofacial clefts in European expert centres
Between unity and disparity: current treatment protocols for common orofacial clefts in European expert centres Open
There is considerable variability in the management of common orofacial clefts across Europe, reflecting differing opinions on optimal treatments. An updated overview of treatment protocols for orofacial clefts across 26 expert centres in …
Histological analysis of the medial gastrocnemius muscle in young healthy children Open
Introduction Histological data on muscle fiber size and proportion in (very) young typically developing (TD) children is not well documented and data on capillarization and satellite cell content are also lacking. Aims This study investiga…
Relation between Maximum Oral Muscle Pressure and Dentoalveolar Characteristics in Patients with Cleft Lip and/or Palate: A Prospective Comparative Study Open
Background: Perioral muscle function, which influences maxillofacial growth and tooth position, can be affected in patients with oral clefts due to their inherent anatomical characteristics and the multiple surgical corrections performed. …
A protocol for a randomized‐controlled trial to investigate the effect of infant sign training on the speech–language development in young children born with cleft palate Open
Background Children born with a cleft palate with or without cleft lip (CP ± L) are known to be at risk for speech–language disorders that impact educational and social–emotional growth. It is hypothesized that speech–language intervention…
Logopedische diagnostiek en behandeling bij kinderen geboren met een lip-, kaak- en verhemeltespleet: een state-of-the-art overzicht Open
Speech diagnosis and treatment of children born with a cleft lip and palate: state-of-the-art overview Children born with a cleft palate, with or without a cleft lip, are susceptible to speech and/or language disorders. Velopharyngeal insu…
How acceptable is the use of linguistic–phonological intervention in children with cleft palate? A qualitative study in speech therapists Open
Background & Aims Even though evidence for the use of linguistic–phonological intervention approaches in children with a cleft (lip and) palate (CP±L) is still limited, these approaches are being used by speech–language pathologists (SLPs)…
Achieving the next level in cleft speech intervention: A protocol of a randomized sham‐controlled trial to provide guidelines for a personalized approach in children with cleft palate Open
Background Compensatory cleft speech disorders can severely impact speech understandability and speech acceptability. Speech intervention is necessary to eliminate these disorders. There is, however, currently no consensus on the most effe…
One size doesn’t fit all : a pilot study towards performance-specific speech intervention in children with a cleft (lip and) palate Open
Purpose. Speech-language pathologists usually apply a “one size fits all” approach to eliminate compensatory cleft speech characteristics (CSCs). It is necessary to investigate what intervention works best for a particular patient. This pi…
Fourth Branchial Anomalies: Diagnosis, Treatment, and Long-Term Outcome Open
Introduction: Fourth branchial anomalies, the rarest among anomalies of the branchial apparatus, often present diagnostic and therapeutic challenges. We evaluated the clinical presentation and radiographic features, the treatment and the l…
View article: 3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies
3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies Open
The analysis of contemporary genomic data typically operates on one-dimensional phenotypic measurements (e.g. standing height). Here we report on a data-driven, family-informed strategy to facial phenotyping that searches for biologically …
View article: The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation
The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation Open
Unaffected relatives of individuals with non-syndromic cleft lip with or without cleft palate (NSCL/P) show distinctive facial features. The presence of this facial endophenotype is potentially an expression of underlying genetic susceptib…
Dermoid cyst of the deep lobe of the parotid gland Open
status: Published
Pregnancy Termination in the Case of an Orofacial Cleft: An Investigation of the Concept of Reproductive Autonomy Open
Objective: To describe ethical approaches to the issue of pregnancy termination after prenatal detection of cleft lip ± palate. Results: Gynecologists and cleft surgeons are sometimes confronted with the demand for a pregnancy termination …
View article: Insights into the genetic architecture of the human face
Insights into the genetic architecture of the human face Open
The human face is complex and multipartite, and characterization of its genetic architecture remains intriguingly challenging. Applying GWAS to multivariate shape phenotypes, we identified 203 genomic regions associated with normal-range f…
Endoscopic Treatment of Idiopathic Subglottic Stenosis: A Systematic Review Open
Purpose: To identify different endoscopic techniques for treatment of idiopathic subglottic stenosis (iSGS) and evaluate treatment results. Methods: Embase and Cochrane Library were searched for publications on endoscopically treated iSGS.…
Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene Open
Non-syndromic cleft lip with or without cleft palate (nsCL/P) ranks among the most common human congenital malformations, and has a multifactorial background in which both exogenous and genetic risk factors act in concert. The present repo…
Vestibular dysfunction is a manifestation of 22q11.2 deletion syndrome Open
The 22q11.2 deletion syndrome (22q11.2DS) is the second most common cause of developmental delay after Down syndrome. Impaired cognitive development is highly prevalent, but also motor abnormalities such as hypotonia and delays in achievin…
Three-dimensional Morphing and Its Added Value in the Rhinoplasty Consult Open
Background: The evolving literature on 3D surface imaging demonstrates that this technology is becoming the preferred simulation technique in hospitals and research centers. However, no study has demonstrated before the superiority of this…
Spatially Dense 3D Facial Heritability and Modules of Co-heritability in a Father-Offspring Design Open
Introduction: The human face is a complex trait displaying a strong genetic component as illustrated by various studies on facial heritability. Most of these start from sparse descriptions of facial shape using a limited set of landmarks. …
Six NSCL/P Loci Show Associations With Normal-Range Craniofacial Variation Open
Objectives: Orofacial clefting is one of the most prevalent craniofacial malformations. Previous research has demonstrated that unaffected relatives of patients with non-syndromic cleft lip with/without cleft palate (NSCL/P) show distincti…
Olfactory function in patients with nonsyndromic orofacial clefts and their unaffected relatives Open
Nonsyndromic orofacial clefting is one of the most frequently occurring congenital conditions. The aim of the study was to investigate the prevalence and nature of reduced olfactory function in patients with nonsyndromic cleft lip and/or c…