Greg Aaen
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View article: Gene–environment interactions: Epstein–Barr virus infection and risk of pediatric-onset multiple sclerosis
Gene–environment interactions: Epstein–Barr virus infection and risk of pediatric-onset multiple sclerosis Open
Background and Objective: Prior Epstein–Barr virus (EBV) infection is associated with an increased risk of pediatric-onset multiple sclerosis (POMS) and adult-onset multiple sclerosis (MS). It has been challenging to elucidate the biologic…
View article: Gene–environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution
Gene–environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution Open
Background: We previously reported a relationship between air pollutants and increased risk of pediatric-onset multiple sclerosis (POMS). Ozone is an air pollutant that may play a role in multiple sclerosis (MS) pathoetiology. CD86 is the …
View article: Pediatric Multiple Sclerosis Severity Score in a large US cohort
Pediatric Multiple Sclerosis Severity Score in a large US cohort Open
Persons with POMS exhibit lower EDSS scores compared to persons with adult-onset MS. Use of a Ped-MSSS model may provide an alternative to EDSS scoring in clinical assessment of disease severity and disability accrual.
View article: Improved relapse recovery in paediatric compared to adult multiple sclerosis
Improved relapse recovery in paediatric compared to adult multiple sclerosis Open
Incomplete relapse recovery contributes to disability accrual and earlier onset of secondary progressive multiple sclerosis. We sought to investigate the effect of age on relapse recovery. We identified patients with multiple sclerosis fro…
View article: Urban air quality and associations with pediatric multiple sclerosis
Urban air quality and associations with pediatric multiple sclerosis Open
Background We previously identified air quality as a risk factor of interest for pediatric multiple sclerosis. The purpose of this study is to more closely examine the association between the six criteria air pollutants and pediatric MS as…
View article: Characteristics of Children and Adolescents With Multiple Sclerosis
Characteristics of Children and Adolescents With Multiple Sclerosis Open
OBJECTIVES: To describe the demographic and clinical characteristics of pediatric multiple sclerosis (MS) in the United States. METHODS: This prospective observational study included children and adolescents with MS. Cases were evaluated a…
View article: Clinical features of neuromyelitis optica in children
Clinical features of neuromyelitis optica in children Open
The new criteria for NMO spectrum disorders apply well to the pediatric setting, and given significant delay in treatment of NMO compared to pediatric MS and worse short-term outcomes, it is imperative to apply these to improve access to t…