Greg Bass
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View article: Automatically quantified follow-up imaging biomarkers predict clinical outcomes after acute ischemic stroke
Automatically quantified follow-up imaging biomarkers predict clinical outcomes after acute ischemic stroke Open
Background Follow-up infarct volume (FIV) is a proposed surrogate endpoint for proof-of-concept clinical studies in acute ischemic stroke (AIS). This study aimed to provide clinical validation of an automated FIV algorithm, demonstrating t…
View article: Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments Open
Spatial proteomics technologies have revealed an underappreciated link between the location of cells in tissue microenvironments and the underlying biology and clinical features, but there is significant lag in the development of downstrea…
View article: 668 A toolkit for the quantitative analysis of the spatial distribution of cells of the tumor immune microenvironment
668 A toolkit for the quantitative analysis of the spatial distribution of cells of the tumor immune microenvironment Open
Background Spatial technologies that query the location of cells in tissues such as multiplex immunohistochemistry and spatial transcriptomics are gaining popularity and are likely to become commonplace. The resulting data often includes t…
View article: SPIAT: An R package for the Spatial Image Analysis of Cells in Tissues
SPIAT: An R package for the Spatial Image Analysis of Cells in Tissues Open
Spatial technologies that query the location of cells in tissues at single-cell resolution are gaining popularity and are likely to become commonplace. The resulting data includes the X, Y coordinates of millions of cells, cell phenotypes …
View article: FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages
FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages Open
The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life of these plasma proteins. However, the pathways for the uptake of these soluble FcRn ligands, and the recyclin…
View article: IP3R Ca2+ release shapes the cytosolic Ca2+ transient for hypertrophic signalling in cardiomyocytes
IP3R Ca2+ release shapes the cytosolic Ca2+ transient for hypertrophic signalling in cardiomyocytes Open
Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signalling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodine receptors (RyRs) for cellular contraction, wh…
View article: Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway
Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway Open
The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic endosomal conditions is recycled to the cell surface where exocytosis and a shift to neutral pH promote extra…