Gregory D. Smith
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View article: A facile route for the chemical functionalisation of polydivinylbenzenes and the application of amphoteric polydivinylbenzene microspheres to the simultaneous solid-phase extraction of acidic and basic drugs from water samples
A facile route for the chemical functionalisation of polydivinylbenzenes and the application of amphoteric polydivinylbenzene microspheres to the simultaneous solid-phase extraction of acidic and basic drugs from water samples Open
Diels–Alder cycloadditions between polydivinylbenzenes and maleic anhydride followed by ring-opening with diamines yields amphoteric polymers with WAX and WCX character.
View article: The Surgical Method of Craniectomy Differentially Affects Acute Seizures, Brain Deformation and Behavior in a TBI Animal Model
The Surgical Method of Craniectomy Differentially Affects Acute Seizures, Brain Deformation and Behavior in a TBI Animal Model Open
Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide. Multiple injury models have been developed to study this neurological disorder. One such model is the lateral fluid-percussion injury (LFPI) rodent mod…
View article: The Surgical Method of Craniectomy Differentially Affects Acute Seizures, Brain Deformation, and Behavior in a Traumatic Brain Injury Animal Model
The Surgical Method of Craniectomy Differentially Affects Acute Seizures, Brain Deformation, and Behavior in a Traumatic Brain Injury Animal Model Open
Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide. Multiple injury models have been developed to study this neurological disorder. One such model is the lateral fluid percussion injury (LFPI) rodent mod…
View article: Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex
Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex Open
Breathing behaviour involves the generation of normal breaths (eupnoea) on a timescale of seconds and sigh breaths on the order of minutes. Both rhythms emerge in tandem from a single brainstem site, but whether and how a single cell popul…
View article: A multigenerational Turing model reproduces transgressive petal spot phenotypes in hybrid<i>Mimulus</i>
A multigenerational Turing model reproduces transgressive petal spot phenotypes in hybrid<i>Mimulus</i> Open
The origin of phenotypic novelty is a perennial question of genetics and evolution. To date, few studies of biological pattern formation specifically address multi-generational aspects of inheritance and phenotypic novelty. For quantitativ…
View article: Rapamycin improves social and stereotypic behavior abnormalities induced by pre‐mitotic neuronal subset specific <i>Pten</i> deletion
Rapamycin improves social and stereotypic behavior abnormalities induced by pre‐mitotic neuronal subset specific <i>Pten</i> deletion Open
The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients and rodent models, mutations to the phosphatase and tensin homolog gene ( PTEN ) on chromosome 10 results in…
View article: Minimal models of the inspiratory and sigh breathing rhythms of the preBötzinger complex
Minimal models of the inspiratory and sigh breathing rhythms of the preBötzinger complex Open
The preBötzinger complex of the lower brainstem generates two breathing-related rhythms: one for inspiration on a timescale of seconds, and another that produces larger amplitude sighs on the order of minutes. We hypothesize that these two…
View article: Population genetics of transposable element load: A mechanistic account of observed overdispersion
Population genetics of transposable element load: A mechanistic account of observed overdispersion Open
In an empirical analysis of transposable element (TE) abundance within natural populations of Mimulus guttatus and Drosophila melanogaster , we found a surprisingly high variance of TE count (e.g., variance-to-mean ratio on the order of 10…
View article: Sigh breathing rhythm depends on intracellular calcium oscillations in a population of inspiratory rhythmogenic preBötzinger complex neurons in mice
Sigh breathing rhythm depends on intracellular calcium oscillations in a population of inspiratory rhythmogenic preBötzinger complex neurons in mice Open
The preBötzinger Complex (preBötC) of the lower brainstem generates two breathing-related rhythms: one for inspiration on a timescale of seconds and another that produces larger amplitude sighs on the order of minutes. Their underlying mec…
View article: Dietary rescue of adult behavioral deficits in the Fmr1 knockout mouse
Dietary rescue of adult behavioral deficits in the Fmr1 knockout mouse Open
The current study aimed to further address important questions regarding the therapeutic efficacy of omega-3 fatty acids for various behavioral and neuroimmune aspects of the Fmr1 phenotype. To address these questions, our experimental des…
View article: Transcriptomes of Electrophysiologically Recorded Dbx1-derived Inspiratory Neurons of the preBötzinger Complex in Neonatal Mice
Transcriptomes of Electrophysiologically Recorded Dbx1-derived Inspiratory Neurons of the preBötzinger Complex in Neonatal Mice Open
Breathing depends on interneurons in the preBötzinger complex (preBötC) derived from Dbx1 -expressing precursors. Here we investigate whether rhythm- and pattern-generating functions reside in discrete classes of Dbx1 preBötC neurons. In a…
View article: Step-Scan Fourier Transform Infrared Absorption Difference Time-Resolved Spectroscopy Studies of Excited State Decay Kinetics and Electronic Structure of Low-Spin d6 Transition Metal Polypyridine Complexes With 10 Nanosecond Time Resolution
Step-Scan Fourier Transform Infrared Absorption Difference Time-Resolved Spectroscopy Studies of Excited State Decay Kinetics and Electronic Structure of Low-Spin d6 Transition Metal Polypyridine Complexes With 10 Nanosecond Time Resolution Open
Step-scan Fourier transform absorption difference time-resolved spectroscopy (S2FTIR ∆A TRS) has been used to collect mid-IR time-resolved infrared spectra of the transient electronic excited states of polypyridine transition metal complex…
View article: Endosperm-based incompatibilities in hybrid monkeyflowers
Endosperm-based incompatibilities in hybrid monkeyflowers Open
Endosperm is an angiosperm innovation central to their reproduction whose development, and thus seed viability, is controlled by genomic imprinting, where expression from certain genes is parent-specific. Unsuccessful imprinting has been l…
View article: DIETARY RESCUE OF ADULT BEHAVIORAL DEFICITS IN THE<i>FMR1</i>KNOCKOUT MOUSE
DIETARY RESCUE OF ADULT BEHAVIORAL DEFICITS IN THE<i>FMR1</i>KNOCKOUT MOUSE Open
The current study aimed to further address important questions regarding the therapeutic efficacy of omega-3 fatty acids for various behavioral and neuroimmune aspects of the Fmr1 phenotype. To address these questions, our experimental des…
View article: The regulatory network for petal anthocyanin pigmentation is shaped by the MYB5a/NEGAN transcription factor in <i>Mimulus</i>
The regulatory network for petal anthocyanin pigmentation is shaped by the MYB5a/NEGAN transcription factor in <i>Mimulus</i> Open
Much of the visual diversity of angiosperms is due to the frequent evolution of novel pigmentation patterns in flowers. The gene network responsible for anthocyanin pigmentation, in particular, has become a model for investigating how gene…
View article: Population genetics of transposable element load: a mechanistic account of observed overdispersion
Population genetics of transposable element load: a mechanistic account of observed overdispersion Open
In an empirical analysis of transposable element (TE) abundance within natural populations of Mimulus guttatus and Drosophila melanogaster , we found a surprisingly high variance of TE count (e.g., variance-to-mean ratio on the order of 10…
View article: Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia
Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia Open
Objective Focal cortical dysplasia (FCD) accounts for nearly half of all cases of medically refractory epilepsy in the pediatric and adult patient populations. This neurological disorder stems from localized malformations in cortical brain…
View article: Role of Synaptic Inhibition in the Coupling of the Respiratory Rhythms that Underlie Eupnea and Sigh Behaviors
Role of Synaptic Inhibition in the Coupling of the Respiratory Rhythms that Underlie Eupnea and Sigh Behaviors Open
The preBötzinger complex (preBötC) gives rise to two types of breathing behavior under normal physiological conditions: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms. We measured breathing …
View article: Role of synaptic inhibition in the coupling of the respiratory rhythms that underlie eupnea and sigh behaviors
Role of synaptic inhibition in the coupling of the respiratory rhythms that underlie eupnea and sigh behaviors Open
The preBötzinger Complex (preBötC) gives rise to two types of breathing behavior: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms by recording from the preBötC in neonatal mouse brainstem sli…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
No abstract is available for this article.
View article: Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling
Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling Open
The purpose of this investigation was to examine cerebellar levels of several molecular signaling pathways, including PI3K/AKT/mammalian target of rapamycin (mTOR) signaling and markers of neuronal migration, following loss of the phosphat…
View article: Mechanisms driving endosperm-based hybrid incompatibilities: insights from hybrid monkeyflowers
Mechanisms driving endosperm-based hybrid incompatibilities: insights from hybrid monkeyflowers Open
Angiosperm endosperm requires genomic and epigenomic interactions between maternal and paternal genomes for proper seed development. Genomic imprinting, an epigenetic phenomenon where the expression of certain genes is predominantly contri…
View article: Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy
Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy Open
Background: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. Previous studies report the drug to be effective in both human and non-human models wi…