Greg Fegan
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View article: The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT
The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT Open
Background Type 1 diabetes is an autoimmune disease affecting over 400,000 children and adults in the United Kingdom for which currently the only available therapy is insulin. Objective(s) To determine the efficacy and safety of the monocl…
View article: Evaluation of an electronic clinical decision support algorithm to improve primary care management of acute febrile illness in rural Cambodia: protocol for a cluster-randomised trial
Evaluation of an electronic clinical decision support algorithm to improve primary care management of acute febrile illness in rural Cambodia: protocol for a cluster-randomised trial Open
Introduction Acute febrile illness (AFI), traditionally attributed to malaria, is a common reason for seeking primary healthcare in rural South and Southeast Asia. However, malaria transmission has declined while health workers are often p…
View article: Improving infant Neurocognitive Development and Growth Outcomes with micronutrients (INDiGO): A protocol for an efficacy trial in rural Gambia
Improving infant Neurocognitive Development and Growth Outcomes with micronutrients (INDiGO): A protocol for an efficacy trial in rural Gambia Open
Background Undernutrition during the early years of life has a harmful and irreversible impact on child growth and cognitive development. Many of the interventions tested to improve outcomes across infancy have had disappointing or inconsi…
View article: Did the COVID-19 pandemic affect levels of burnout, anxiety and depression among doctors and nurses in Bangladesh? A cross-sectional survey study
Did the COVID-19 pandemic affect levels of burnout, anxiety and depression among doctors and nurses in Bangladesh? A cross-sectional survey study Open
Introduction COVID-19 has caused severe disruption to clinical services in Bangladesh but the extent of this, and the impact on healthcare professionals is unclear. We aimed to assess the perceived levels of anxiety, depression and burnout…
View article: Social deprivation independently impacts clinical outcomes in patients with chronic lymphocytic leukemia.
Social deprivation independently impacts clinical outcomes in patients with chronic lymphocytic leukemia. Open
Not available.
View article: SP9.14 “Happy to close?”: The relationship between surgical experience and incisional hernia rates following abdominal wall closure in colorectal surgery
SP9.14 “Happy to close?”: The relationship between surgical experience and incisional hernia rates following abdominal wall closure in colorectal surgery Open
Introduction There is an association between surgeon volume and outcomes in hernia surgery, yet little evidence regarding impact of the experience of the surgeon performing abdominal wall closure (AWC) on IH rate. Our aim was to assess the…
View article: “Happy to close?” The relationship between surgical experience and incisional hernia rates following abdominal wall closure in colorectal surgery
“Happy to close?” The relationship between surgical experience and incisional hernia rates following abdominal wall closure in colorectal surgery Open
Aim Incisional hernia (IH) is a common complication of colorectal surgery, affecting up to 30% of patients at 2 years. Given the associated morbidity and high recurrence rates after attempted repair of IH, emphasis should be placed on prev…
View article: A novel blood based triage test for colorectal cancer in primary care: a pilot study
A novel blood based triage test for colorectal cancer in primary care: a pilot study Open
Background The majority of colorectal cancers (CRCs) are detected after symptomatic presentation to primary care. Given the shared symptoms of CRC and benign disorders, it is challenging to manage the risk of missed diagnosis. Colonoscopy …
View article: OC-050 “HAPPY TO CLOSE?”: THE RELATIONSHIP BETWEEN SURGICAL EXPERIENCE AND INCISIONAL HERNIA RATES FOLLOWING ABDOMINAL WALL CLOSURE IN COLORECTAL SURGERY
OC-050 “HAPPY TO CLOSE?”: THE RELATIONSHIP BETWEEN SURGICAL EXPERIENCE AND INCISIONAL HERNIA RATES FOLLOWING ABDOMINAL WALL CLOSURE IN COLORECTAL SURGERY Open
Introduction Incisional Hernia (IH) is a common complication of colorectal surgery. Given high recurrence rates and associated morbidity, emphasis must be on prevention of IH. There is an association between surgeon volume and outcomes in …
View article: Incisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART)
Incisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART) Open
Background Incisional hernias cause morbidity and may require further surgery. HART (Hughes Abdominal Repair Trial) assessed the effect of an alternative suture method on the incidence of incisional hernia following colorectal cancer surge…
View article: Hughes abdominal closure versus standard mass closure to reduce incisional hernias following surgery for colorectal cancer: the HART RCT
Hughes abdominal closure versus standard mass closure to reduce incisional hernias following surgery for colorectal cancer: the HART RCT Open
Background Incisional hernias can cause chronic pain and complications and affect quality of life. Surgical repair requires health-care resources and has a significant associated failure rate. A prospective, multicentre, single-blinded ran…
View article: Sun Safety Education in a Maritime Climate
Sun Safety Education in a Maritime Climate Open
Dear Editor, With an average 156 days of rain a year in the United Kingdom (UK), it's no surprise that when the sun comes out, the British approach is to 'make the most of it'. Spend a sunny day at any UK beach and you'll see several sunbu…
View article: Sunproofed study protocol: A mixed-methods scoping study of sun safety policies in primary schools in Wales
Sunproofed study protocol: A mixed-methods scoping study of sun safety policies in primary schools in Wales Open
Background Skin cancer, including melanoma and non-melanoma (keratinocyte), is increasing in incidence in the UK. Accounting for half of all cancers in England and Wales, the disease significantly impacts overstretched dermatology services…
View article: MORU Tropical Health Network Annual Report 2021
MORU Tropical Health Network Annual Report 2021 Open
2021 Annual Report for the MORU Tropical Health Network, Mahidol Oxford Tropical Medicine Research Unit
View article: Dementia Early-Stage Cognitive Aids New Trial (DESCANT) of memory aids and guidance for people with dementia: randomised controlled trial
Dementia Early-Stage Cognitive Aids New Trial (DESCANT) of memory aids and guidance for people with dementia: randomised controlled trial Open
Background Common memory aids for people with dementia at home are recommended. However, rigorous evaluation is lacking, particularly what guidance or support is valued. Objective To investigate effects of memory aids and guidance by demen…
View article: Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): trial protocol
Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): trial protocol Open
Introduction Most individuals newly diagnosed with type 1 diabetes (T1D) have 10%–20% of beta-cell function remaining at the time of diagnosis. Preservation of residual beta-cell function at diagnosis may improve glycaemic control and redu…
View article: Components, impacts and costs of dementia home support: a research programme including the DESCANT RCT
Components, impacts and costs of dementia home support: a research programme including the DESCANT RCT Open
Background Over half of people with dementia live at home. We know little about what home support could be clinically effective or cost-effective in enabling them to live well. Objectives We aimed to (1) review evidence for components of h…
View article: Mortality during and following hospital admission among school-aged children: a cohort study
Mortality during and following hospital admission among school-aged children: a cohort study Open
Background: Far less is known about the reasons for hospitalization or mortality during and after hospitalization among school-aged children than among under-fives in low- and middle-income countries. This study aimed to describe common ty…
View article: Solutions to COVID-19 data sharing
Solutions to COVID-19 data sharing Open
We read with interest The Lancet Digital Health Editorial regarding transparency during global health emergencies, and we wanted to bring to your readers' attention our work on data sharing.1The Lancet Digital HealthTransparency during glo…
View article: Excess mortality among people with podoconiosis: secondary analysis of two Ethiopian cohorts
Excess mortality among people with podoconiosis: secondary analysis of two Ethiopian cohorts Open
Background While morbidity attributable to podoconiosis is relatively well studied, its pattern of mortality has not been established. Methods We compared the age-standardised mortality ratios (SMRs) of two datasets from northern Ethiopia:…
View article: Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa
Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa Open
BackgroundPatients with acute HIV-1 infection (AHI) have elevated infectivity, but cannot be diagnosed using antibody-based testing. Approaches to screen patients for AHI are urgently needed to enable counselling and treatment to reduce on…
View article: Mortality during and following hospital admission among school-aged children: a cohort study
Mortality during and following hospital admission among school-aged children: a cohort study Open
Background: Far less is known about the reasons for hospitalization or mortality during and after hospitalization among school-aged children than under-fives in low- and middle-income countries. This study aimed to describe common types of…
View article: A new method to triage colorectal cancer referrals in the UK using serum Raman spectroscopy and machine learning
A new method to triage colorectal cancer referrals in the UK using serum Raman spectroscopy and machine learning Open
Suspected colorectal cancer (CRC) referrals based on non-specific symptoms currently lead to large numbers of patients being referred for invasive investigations and poor yield in cancer detection. Secondary care diagnostics, particularly …
View article: Is fascia iliaca compartment block administered by paramedics for suspected hip fracture acceptable to patients? A qualitative study
Is fascia iliaca compartment block administered by paramedics for suspected hip fracture acceptable to patients? A qualitative study Open
Objective To explore patients’ experience of receiving pain relief injection for suspected hip fracture from paramedics at the location of the injury. Design Qualitative interviews within a feasibility trial about an alternative to routine…