Gregory L. Kinney
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View article: Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan
Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan Open
Maternal smoking was linked to reduced circulating and airway CC16 in COPD patients, controls, and a preclinical murine COPD model. In human adults, lower CC16 correlated with accelerated lung function decline and emphysema progression, wh…
View article: MON-457 Plasma Cortisol and Salivary Cortisone Are Clinically Useful for Managing Adrenal Insufficiency
MON-457 Plasma Cortisol and Salivary Cortisone Are Clinically Useful for Managing Adrenal Insufficiency Open
Disclosure: J.G. Kallet: None. W. Hover: None. A.D. Krein: None. J.L. Crooks: None. G.L. Kinney: None. M.F. Slovick: None. U. Christians: None. B. Schniedewind: None. S. Majka: None. M.T. McDermott: None. E.A. Regan: None. Adrenal insuffic…
View article: Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study
Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study Open
These findings highlight the importance of understanding factors that increase risk for depression and anxiety among smokers at risk for or with COPD and are moderated by sex.
View article: Use of the Wnt/β-catenin Activator Lithium Is Associated with Less Emphysema
Use of the Wnt/β-catenin Activator Lithium Is Associated with Less Emphysema Open
Rationale Emphysema is defined by progressive alveolar destruction and impaired tissue repair, with diminished Wnt/β-catenin signaling implicated in its pathogenesis. Preclinical studies suggest that lithium, a pharmacologic activator of W…
View article: The Prevalence of Type 1 Diabetes in Hispanic/Latino Populations in the United States: Findings from the Hispanic Community Health Study/Study of Latinos.
The Prevalence of Type 1 Diabetes in Hispanic/Latino Populations in the United States: Findings from the Hispanic Community Health Study/Study of Latinos. Open
Estimates of type 1 diabetes in "All Hispanic" and Mexican-American populations were reported in 2013 using National Health and Nutrition Examination Survey (NHANES) data collected between 1999 and 2010, but this study did not examine suff…
View article: Interstitial lung abnormalities, coronary heart disease and mortality
Interstitial lung abnormalities, coronary heart disease and mortality Open
Background Interstitial lung abnormalities (ILA) share common risk factors with coronary heart disease (CHD), including increased age and cigarette smoking; however, the relationship between ILA and CHD has not been well described. Methods…
View article: B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort
B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort Open
Rationale Cigarette smoking (CS) impairs B-cell function and antibody production, increasing infection risk. The impact of e-cigarette use ('vaping') and combined CS and vaping ('dual-use') on B-cell activity is unclear. Objective To exami…
View article: Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants
Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants Open
Background Genome‐wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant‐based genome‐wide association studies improving our u…
View article: Impact of prenatal exposure to delta 9‐tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories
Impact of prenatal exposure to delta 9‐tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories Open
Summary Background Prenatal exposure to cannabis (or more specifically, delta 9‐tetrahydrocannabinol [Δ9‐THC]) has been consistently linked to low birthweight. Animal models further show that Δ9‐THC is associated with rapid postnatal growt…
View article: Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes
Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes Open
Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-…
View article: Plasma Proteomic Markers of Iron and Risk of Diabetes in a Cohort of African American and White American Current and Former Smokers
Plasma Proteomic Markers of Iron and Risk of Diabetes in a Cohort of African American and White American Current and Former Smokers Open
Higher body iron stores is associated with increased diabetes risk among both NHB and NHW people. Unsuspected elevated iron stores may increase diabetes risk in NHB patients and should be monitored.
View article: Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes
Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes Open
Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-…
View article: Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes
Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes Open
Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large metagenome-wide association studies (GWAS) of C-…
View article: Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes
Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes Open
Identified genetic loci for C-peptide and age at diagnosis (AAD) in individuals with type 1 diabetes (T1D) explain only a small proportion of their variation. Here, we aimed to perform large meta–genome-wide association studies (GWAS) of C…
View article: Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies
Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies Open
National Institutes of Health.
View article: B cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort
B cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort Open
Rationale Cigarette smoking (CS) impairs B cell function and antibody production, increasing infection risk. The impact of e-cigarette use (’vaping’) and combined CS and vaping (’dual-use’) on B cell activity is unclear. Objective To exami…
View article: Epidemiologic Features of Recovery From SARS-CoV-2 Infection
Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open
Importance: Persistent symptoms and disability following SARS-CoV-2 infection, known as post-COVID-19 condition or "long COVID," are frequently reported and pose a substantial personal and societal burden. Objective: To determine time to r…
View article: 8205 Within day Symptoms Of Adrenal Insufficiency Predict Reduced Quality Of Life And Adrenal Crises In 712 MyAI Registry Participants
8205 Within day Symptoms Of Adrenal Insufficiency Predict Reduced Quality Of Life And Adrenal Crises In 712 MyAI Registry Participants Open
Disclosure: J.G. Kallet: None. W. Hover: None. A. Krein: None. M. Lowe: None. M.F. Slovick: None. G. Kinney: None. S. Majka: None. K. Warren: None. S. Watts: None. M.T. McDermott: None. E.A. Regan: None. Multiple studies have shown reduced…
View article: 8555 Hourly Assessment Of Symptoms In 16 Adrenal Insufficiency Patients Correlates With AddiQoL
8555 Hourly Assessment Of Symptoms In 16 Adrenal Insufficiency Patients Correlates With AddiQoL Open
Disclosure: J.G. Kallet: None. W. Hover: None. A. Krein: None. M.F. Slovick: None. S. Majka: None. G.L. Kinney: None. S. Watts: None. M.T. McDermott: None. E.A. Regan: None. Background: A major challenge in the treatment of adrenal insuffi…
View article: Childhood exposure to cannabidiol and lung function: A pilot study
Childhood exposure to cannabidiol and lung function: A pilot study Open
Cannabidiol (CBD) use has increased substantially in recent years, particularly since the legalization of hemp-derived CBD through the United States 2018 Agriculture Improvement Act. In the same year, the World Health Organization indicate…
View article: Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking
Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking Open
Background: Coronary artery calcium (CAC) is a marker of subclinical atherosclerosis and is a complex heritable trait with both genetic and environmental risk factors, including sex and smoking. Methods: We performed genome-wide associatio…
View article: Epidemiologic Features of Recovery From SARS-CoV-2 Infection
Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open
Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as post–COVID-19 condition or “long COVID,” are frequently reported and pose a substantial personal and societal burden. Objective To determine time to rec…
View article: Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts
Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts Open
Objective To compare longitudinal changes in spirometric measures between patients with rheumatoid arthritis (RA) and non-RA comparators. Methods We analysed longitudinal data from two prospective cohorts: the UK Biobank and COPDGene. Spir…
View article: Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study
Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study Open
Background Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations not only contribute to COPD progression but may also elevate the risk of CVD. This …