Greg Knoll
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View article: Association Between Peritoneal Dialysis-Associated Peritonitis and the Risk of All-Cause Mortality and Cardiovascular Death: A Time-Matched Retrospective Cohort Study
Association Between Peritoneal Dialysis-Associated Peritonitis and the Risk of All-Cause Mortality and Cardiovascular Death: A Time-Matched Retrospective Cohort Study Open
Background/Objectives: Although peritoneal dialysis (PD) practices have improved over the past decades, limited evidence exists on all-cause mortality and cardiovascular death following PD-associated peritonitis. This study aimed to invest…
View article: Effectiveness of predictive scoring systems in predicting mortality in relation to baseline kidney function in adult intensive care unit patients: a systematic review protocol
Effectiveness of predictive scoring systems in predicting mortality in relation to baseline kidney function in adult intensive care unit patients: a systematic review protocol Open
Introduction Predictive scoring systems support clinicians in decision-making by estimating the prognosis of patients in intensive care units (ICUs). However, there is limited evidence on the accuracy of these systems in predicting mortali…
View article: Optimizing the Use of Deceased Donor Kidneys at Risk of Discard: A Clinical Practice Guideline
Optimizing the Use of Deceased Donor Kidneys at Risk of Discard: A Clinical Practice Guideline Open
Underutilization of deceased donor organs has worsened the gap in the number of kidneys available for transplantation. The purpose of this clinical practice guideline is to provide recommendations on the utilization of donor kidneys at ris…
View article: Infection Risks With Thymoglobulin Use for Delayed Graft Function in Deceased Donor Kidney Transplantation: Research Letter
Infection Risks With Thymoglobulin Use for Delayed Graft Function in Deceased Donor Kidney Transplantation: Research Letter Open
Anti-thymocyte globulin (ATG) is often used when delayed graft function (DGF) occurs post-transplantation. The ATG may be associated with an increased risk of infections but may also decrease rejection risk in high-immunological risk recip…
View article: A population-based cohort study defined estimated glomerular filtration rate decline and kidney failure among Canadian immigrants
A population-based cohort study defined estimated glomerular filtration rate decline and kidney failure among Canadian immigrants Open
The link between immigrant status, a key social determinant of health, and kidney disease remains uncertain. To evaluate this, we compared incident adverse kidney outcomes between immigrants and non-immigrants using Canadian provincial hea…
View article: Testicular Pain After Living Kidney Donation: Results From a Multicenter Cohort Study
Testicular Pain After Living Kidney Donation: Results From a Multicenter Cohort Study Open
Background: Some men who donate a kidney have reported testicular pain after donation; however, attribution to donation is not clear as no prior studies included a comparison group of nondonors. Objective: To examine the proportion of male…
View article: Defining Referral for a Kidney Transplant Evaluation as a Quality Indicator: A Population-Based Cohort Study
Defining Referral for a Kidney Transplant Evaluation as a Quality Indicator: A Population-Based Cohort Study Open
Background: Quality indicators are required to identify gaps in care and to improve equitable access to kidney transplants. Referral to a transplant center for an evaluation is the first step toward receiving a kidney transplant, yet wides…
View article: Variation in Kidney Transplant Referral, Living Donor Contacts, Waitlisting, and Kidney Transplant Across Regional Renal Programs in Ontario, Canada: A Population-Based Cohort Study
Variation in Kidney Transplant Referral, Living Donor Contacts, Waitlisting, and Kidney Transplant Across Regional Renal Programs in Ontario, Canada: A Population-Based Cohort Study Open
Background: Previous studies conducted in publicly and privately funded health care systems suggest that access to kidney transplants may vary depending on where a patient receives their kidney care. It is poorly understood whether variabi…
View article: A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients
A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients Open
Cancer is a major cause of morbidity and mortality in kidney transplant recipients. Health professionals have a critical role in promoting cancer screening participation. From March 2023 to February 2024, an online survey was distributed t…
View article: Misclassification of Hypertension Status According to Office Blood Pressure vs 24-Hour Ambulatory Blood Pressure Monitoring
Misclassification of Hypertension Status According to Office Blood Pressure vs 24-Hour Ambulatory Blood Pressure Monitoring Open
View article: Testicular pain after living kidney donation: Results from a multicenter cohort study
Testicular pain after living kidney donation: Results from a multicenter cohort study Open
Background Some men who donate a kidney have reported testicular pain after donation; however, attribution to donation is not clear as no prior studies included a comparison group of nondonors. Objective To examine the proportion of male d…
View article: Incident chronic kidney disease among Canadian immigrants: a population-based cohort study
Incident chronic kidney disease among Canadian immigrants: a population-based cohort study Open
Introduction A ‘healthy immigrant effect’ has been demonstrated for a number of chronic health conditions including cardiovascular disease, diabetes mellitus and dementia; however, the link between immigrant status and kidney health remain…
View article: Bringing a Systems Approach to Living Donor Kidney Transplantation
Bringing a Systems Approach to Living Donor Kidney Transplantation Open
View article: Adherence to guideline‐recommended care of late‐onset hypertension in females versus males: A population‐based cohort study
Adherence to guideline‐recommended care of late‐onset hypertension in females versus males: A population‐based cohort study Open
Background Sex‐based disparities in cardiovascular outcomes may be improved with appropriate hypertension management. Objective To compare the evidence‐based evaluation and management of females with late‐onset hypertension compared to mal…
View article: Comparison of COVID-19 Hospitalization and Death Between Solid Organ Transplant Recipients and the General Population in Canada, 2020–2022
Comparison of COVID-19 Hospitalization and Death Between Solid Organ Transplant Recipients and the General Population in Canada, 2020–2022 Open
Background. Solid organ transplant recipients have a high risk of severe outcomes from SARS-CoV-2 infection. A comprehensive understanding of the impact of the COVID-19 pandemic across multiple waves in the solid organ transplant populatio…
View article: Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial
Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial Open
Introduction Most solid organ transplants originate from donors meeting criteria for death by neurological criteria (DNC). Within the organ donor, physiological responses to brain death increase the risk of ischaemia reperfusion injury and…
View article: Hypertension and Kidney Function After Living Kidney Donation
Hypertension and Kidney Function After Living Kidney Donation Open
Importance Recent guidelines call for better evidence on health outcomes after living kidney donation. Objective To determine the risk of hypertension in normotensive adults who donated a kidney compared with nondonors of similar baseline …
View article: Sex-Related Disparities in Cardiovascular Outcomes Among Older Adults With Late-Onset Hypertension
Sex-Related Disparities in Cardiovascular Outcomes Among Older Adults With Late-Onset Hypertension Open
BACKGROUND: It is unclear whether sex-based differences in cardiovascular outcomes exist in late-onset hypertension. METHODS: This is a population-based cohort study in Ontario, Canada of 266 273 adults, aged ≥66 years with newly diagnosed…
View article: The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation
The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation Open
BK polyomavirus (BKPyV) remains a significant challenge after kidney transplantation. International experts reviewed current evidence and updated recommendations according to Grading of Recommendations, Assessment, Development, and Evaluat…
View article: Physical Frailty and Functional Status in Kidney Transplantation: A Systematic Review
Physical Frailty and Functional Status in Kidney Transplantation: A Systematic Review Open
Background: Frailty and functional decline are being recognized as important conditions in kidney transplant candidates. However, the ideal measures of functional status and frailty remain unknown as there is not a complete understanding o…
View article: Epidemiology of Cancer in Kidney Transplant Recipients
Epidemiology of Cancer in Kidney Transplant Recipients Open
Kidney transplantation is the ideal treatment modality for patients with end-stage kidney disease, with excellent outcomes post-transplant compared with dialysis. However, kidney transplant recipients are at increased risk of infections an…
View article: Implementation of a 1-Day Living Kidney Donor Evaluation Program: A Qualitative Analysis of Donor Candidate and Stakeholder Perspectives
Implementation of a 1-Day Living Kidney Donor Evaluation Program: A Qualitative Analysis of Donor Candidate and Stakeholder Perspectives Open
View article: Calcineurin Inhibition in Deceased Organ Donors: A Systematic Review and Meta-analysis of Preclinical Studies
Calcineurin Inhibition in Deceased Organ Donors: A Systematic Review and Meta-analysis of Preclinical Studies Open
Background. Preconditioning deceased organ donors with calcineurin inhibitors (CNIs) may reduce ischemia–reperfusion injury to improve transplant outcomes. Methods. We searched MEDLINE, EMBASE, Cochrane Library, and conference proceedings …
View article: Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study
Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study Open
Objective To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design Retrospective, population based cohort study. Setting Linked healthcare administrative datasets …
View article: Risk of venous thromboembolism or hemorrhage among individuals with chronic kidney disease on prophylactic anticoagulant after hip or knee arthroplasty
Risk of venous thromboembolism or hemorrhage among individuals with chronic kidney disease on prophylactic anticoagulant after hip or knee arthroplasty Open
Chronic kidney disease (CKD) confers a high risk of thrombosis and bleeding. However, little evidence exists regarding the optimal choice of postoperative thromboprophylaxis in these patients. We conducted a population‐based, retrospective…
View article: #2996 EARLY DECLINES IN KIDNEY FUNCTION AND ADVERSE OUTCOMES IN YOUNG ADULTS
#2996 EARLY DECLINES IN KIDNEY FUNCTION AND ADVERSE OUTCOMES IN YOUNG ADULTS Open
Background and Aims Whether early eGFR declines (eGFR below age-expected values) in younger adults are associated with adverse outcomes is unknown. We aim to estimate the association of an early eGFR decline with adverse outcomes by age gr…
View article: Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Open
View article: Table of Contents
Table of Contents Open
View article: Management and Outcome of COVID-19 Infection Using Nirmatrelvir/Ritonavir in Kidney Transplant Patients
Management and Outcome of COVID-19 Infection Using Nirmatrelvir/Ritonavir in Kidney Transplant Patients Open
Background Nirmatrelvir/ritonavir has been shown to reduce the risk of coronavirus disease 2019 (COVID-19)–related complications in patients at high risk for severe COVID-19. However, clinical experience of nirmatrelvir/ritonavir in the tr…
View article: Diagnostic accuracy of ancillary tests for death by neurologic criteria: a systematic review and meta-analysis
Diagnostic accuracy of ancillary tests for death by neurologic criteria: a systematic review and meta-analysis Open