Greg M. Findlay
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View article: Phosphorylation enables progressive microtubule-associated protein proteolysis and functionalisation during neural development
Phosphorylation enables progressive microtubule-associated protein proteolysis and functionalisation during neural development Open
Neurological diseases are frequently characterised by dysregulation of the microtubule cytoskeleton, which is critical for neuronal integrity and functioning. However, the precise mechanisms by which microtubule dynamics are regulated duri…
View article: Author response: Proteomic and functional comparison between human induced and embryonic stem cells
Author response: Proteomic and functional comparison between human induced and embryonic stem cells Open
View article: Proteomic and functional comparison between human induced and embryonic stem cells
Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise the proteomes of multiple hiPSC an…
View article: Proteomic and functional comparison between human induced and embryonic stem cells
Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding many of the ethical issues arising from the use …
View article: Author response: Proteomic and functional comparison between human induced and embryonic stem cells
Author response: Proteomic and functional comparison between human induced and embryonic stem cells Open
View article: The ERK5 MAP kinase regulates annexin complexes and membrane dynamics in embryonic stem cells
The ERK5 MAP kinase regulates annexin complexes and membrane dynamics in embryonic stem cells Open
Summary The ERK5 MAP kinase signalling pathway controls key processes in mouse Embryonic Stem Cells (mESCs) maintenance, including expression of naïve pluripotency genes and a transcriptional programme for stem cell rejuvenation. However, …
View article: A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation
A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation Open
The generation of distinct cell fates during development depends on asymmetric cell division of progenitor cells. In the central and peripheral nervous system of Drosophila, progenitor cells respectively called neuroblasts or sensory organ…
View article: Author response: A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation
Author response: A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation Open
View article: Reviewer #3 (Public Review): Proteomic and functional comparison between human induced and embryonic stem cells
Reviewer #3 (Public Review): Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding ethical issues arising from the use of embryo-de…
View article: None: Proteomic and functional comparison between human induced and embryonic stem cells
None: Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding ethical issues arising from the use of embryo-de…
View article: Proteomic and functional comparison between human induced and embryonic stem cells
Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding ethical issues arising from the use of embryo-de…
View article: Reviewer #2 (Public Review): Proteomic and functional comparison between human induced and embryonic stem cells
Reviewer #2 (Public Review): Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding ethical issues arising from the use of embryo-de…
View article: Proteomic and functional comparison between human induced and embryonic stem cells
Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise the proteomes of multiple hiPSC an…
View article: Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses Open
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and …
View article: Roles of the Rlim–Rex1 axis during X chromosome inactivation in mice
Roles of the Rlim–Rex1 axis during X chromosome inactivation in mice Open
In female mice, the gene dosage from X chromosomes is adjusted by a process called X chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) that silences the paternally inherited X chromosome (Xp) is initia…
View article: Functions of<scp>SRPK</scp>,<scp>CLK</scp>and<scp>DYRK</scp>kinases in stem cells, development, and human developmental disorders
Functions of<span>SRPK</span>,<span>CLK</span>and<span>DYRK</span>kinases in stem cells, development, and human developmental disorders Open
Human developmental disorders encompass a wide range of debilitating physical conditions and intellectual disabilities. Perturbation of protein kinase signalling underlies the development of some of these disorders. For example, disrupted …
View article: Asymmetric cell division-specific phosphorylation of PAR-3 regulates neuroblasts polarisation and sensory organ formation in <i>Drosophila</i>
Asymmetric cell division-specific phosphorylation of PAR-3 regulates neuroblasts polarisation and sensory organ formation in <i>Drosophila</i> Open
The generation of distinct cell fates during development depends on asymmetric cell division of progenitor cells. In the central and peripheral nervous system of Drosophila, progenitor cells respectively called neuroblasts or sensory organ…
View article: Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcription
Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcription Open
Summary The E3 ubiquitin ligase RNF12/RLIM controls developmental gene expression and is mutated in the X-linked intellectual disability disorder Tonne-Kalscheuer syndrome (TOKAS). However, the mechanisms by which RNF12 E3 ubiquitin ligase…
View article: Cell autonomous requirement of imprinted XCI in extra-embryonic polar trophoblast cells
Cell autonomous requirement of imprinted XCI in extra-embryonic polar trophoblast cells Open
Summary In female mice the gene dosage from X chromosomes is adjusted by a process called X chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) silencing the paternally inherited X chromosome (Xp) is ini…
View article: An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations
An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations Open
The E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene encoding it, RLIM , is mutated in the X-linked human developmental disorder Tonne-Kalscheuer syndrome (TOKAS). Substrates of RNF12 include transcriptional…
View article: Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome
Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome Open
Ubiquitylation enzymes are involved in all aspects of eukaryotic biology and are frequently disrupted in disease. One example is the E3 ubiquitin ligase RNF12/RLIM, which is mutated in the developmental disorder Tønne-Kalscheuer syndrome (…
View article: Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability
Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability Open
Intellectual disability (ID) represents a major burden on healthcare systems in the developed world. However, there is a disconnect between our knowledge of genes that are mutated in ID and our understanding of the underpinning molecular m…
View article: LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain
LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain Open
Protein phosphatases are major regulators of signal transduction and they are involved in key cellular mechanisms such as proliferation, differentiation, and cell survival. Here we focus on one class of protein phosphatases, the type IIA R…
View article: Proteomic and functional comparison between human induced and embryonic stem cells
Proteomic and functional comparison between human induced and embryonic stem cells Open
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding many of the ethical issues arising from the use …
View article: A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne–Kalscheuer syndrome
A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne–Kalscheuer syndrome Open
View article: An ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation
An ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation Open
Summary The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not been investigated. Here, we employ qu…
View article: An ERK5-KLF2 Signalling Module Regulates Early Embryonic Gene Expression Dynamics and Stem Cell Rejuvenation
An ERK5-KLF2 Signalling Module Regulates Early Embryonic Gene Expression Dynamics and Stem Cell Rejuvenation Open
View article: A novel<i>RLIM/RNF12</i>variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome
A novel<i>RLIM/RNF12</i>variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome Open
Tonne-Kalscheuer syndrome (TOKAS) is an X-linked intellectual disability syndrome associated with variable clinical features including craniofacial abnormalities, hypogenitalism and diaphragmatic hernia. TOKAS is caused exclusively by vari…
View article: A RNF12-USP26 amplification loop promotes germ cell specification and is disrupted in urogenital disorders
A RNF12-USP26 amplification loop promotes germ cell specification and is disrupted in urogenital disorders Open
Summary Ubiquitylation regulates all aspects of development, and components are frequently mutated in developmental disorders. Tonne-Kalscheuer Syndrome (TOKAS) is a X-linked multiple congenital anomaly disorder caused by mutations in the …
View article: Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal
Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal Open
The self‐renewal efficiency of mouse embryonic stem cells (ESCs) is determined by the concentration of the transcription factor NANOG. While NANOG binds thousands of sites in chromatin, the regulatory systems that control DNA binding are p…