Greg Odorizzi
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View article: Wbm0152, an outer membrane lipoprotein of the Wolbachia endosymbiont of Brugia malayi, inhibits yeast ESCRT complex activity
Wbm0152, an outer membrane lipoprotein of the Wolbachia endosymbiont of Brugia malayi, inhibits yeast ESCRT complex activity Open
Human pathogenic filarial nematodes of the family Onchocercidae, including Brugia malayi and Onchocerca volvulus, cause debilitating filarial diseases such as lymphatic filariasis and river blindness. These arthropod-borne pathogens are ob…
View article: Wbm0152, an outer membrane lipoprotein of the <i>Wolbachia</i> endosymbiont of <i>Brugia malayi</i>, inhibits yeast ESCRT complex activity
Wbm0152, an outer membrane lipoprotein of the <i>Wolbachia</i> endosymbiont of <i>Brugia malayi</i>, inhibits yeast ESCRT complex activity Open
Human pathogenic filarial nematodes of the family Onchocercidae, including Brugia malayi and Onchocerca volvulus, cause debilitating filarial diseases such as lymphatic filariasis and river blindness. These mosquito-borne pathogens are obl…
View article: Disordered hinge regions of the AP-3 adaptor complex promote vesicle budding from the late Golgi in yeast
Disordered hinge regions of the AP-3 adaptor complex promote vesicle budding from the late Golgi in yeast Open
Vesicles bud from maturing Golgi cisternae in a programmed sequence. Budding is mediated by adaptors that recruit cargoes and facilitate vesicle biogenesis. In Saccharomyces cerevisiae, the AP-3 adaptor complex directs cargoes from the Gol…
View article: Mitochondrial-derived compartments are multilamellar domains that encase membrane cargo and cytosol
Mitochondrial-derived compartments are multilamellar domains that encase membrane cargo and cytosol Open
Preserving the health of the mitochondrial network is critical to cell viability and longevity. To do so, mitochondria employ several membrane remodeling mechanisms, including the formation of mitochondrial-derived vesicles (MDVs) and comp…
View article: A role for Vps13-mediated lipid transfer at the ER–endosome contact site in ESCRT-mediated sorting
A role for Vps13-mediated lipid transfer at the ER–endosome contact site in ESCRT-mediated sorting Open
Endosomes are specialized organelles that function in the secretory and endocytic protein sorting pathways. Endocytosed cell surface receptors and transporters destined for lysosomal degradation are sorted into intraluminal vesicles (ILVs)…
View article: Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms
Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms Open
Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal feature of aging and mitochondrial diseases,…
View article: Author response: Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms
Author response: Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mitocho…
View article: Vps60 initiates alternative ESCRT-III filaments
Vps60 initiates alternative ESCRT-III filaments Open
Endosomal sorting complex required for transport-III (ESCRT-III) participates in essential cellular functions, from cell division to endosome maturation. The remarkable increase of its subunit diversity through evolution may have enabled t…
View article: Mitochondrial-Derived Compartments are Multilamellar Domains that Encase Membrane Cargo and Cytosol
Mitochondrial-Derived Compartments are Multilamellar Domains that Encase Membrane Cargo and Cytosol Open
Preserving the health of the mitochondrial network is critical to cell viability and longevity. To do so, mitochondria employ several membrane remodeling mechanisms, including the formation of mitochondrial-derived vesicles (MDVs) and comp…
View article: A role for Vps13-mediated lipid transfer at the ER-endosome contact site in ESCRT-mediated sorting
A role for Vps13-mediated lipid transfer at the ER-endosome contact site in ESCRT-mediated sorting Open
Endosomes are specialized organelles that function in the secretory and endocytic protein sorting pathways. Endocytosed cell surface receptors and transporters destined for lysosomal degradation are sorted into intralumenal vesicles (ILVs)…
View article: Vps60 initiates alternative ESCRT-III filaments
Vps60 initiates alternative ESCRT-III filaments Open
Source data for :"Vps60 initiates alternative ESCRT-III filaments"
View article: Vps60 initiates alternative ESCRT-III filaments
Vps60 initiates alternative ESCRT-III filaments Open
Source data for :"Vps60 initiates alternative ESCRT-III filaments"
View article: Bro1 binds the Vps20 subunit of<scp>ESCRT‐III</scp>and promotes<scp>ESCRT‐III</scp>regulation by Doa4
Bro1 binds the Vps20 subunit of<span>ESCRT‐III</span>and promotes<span>ESCRT‐III</span>regulation by Doa4 Open
The budding of intralumenal vesicles (ILVs) at endosomes requires membrane scission by the ESCRT‐III complex. This step is negatively regulated in yeast by Doa4, the ubiquitin hydrolase that deubiquitinates transmembrane proteins sorted as…
View article: Vacuolar H+-ATPase dysfunction rescues intralumenal vesicle cargo sorting in yeast lacking PI(3,5)P2 or Doa4
Vacuolar H+-ATPase dysfunction rescues intralumenal vesicle cargo sorting in yeast lacking PI(3,5)P2 or Doa4 Open
Endosomes undergo a maturation process highlighted by a reduction in lumenal pH, a conversion of surface markers that prime endosome–lysosome fusion and the sequestration of ubiquitylated transmembrane protein cargos within intralumenal ve…
View article: Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis
Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis Open
Endosomal sorting complexes required for transport (ESCRT-0, -I, -II, -III) execute cargo sorting and intralumenal vesicle (ILV) formation during conversion of endosomes to multivesicular bodies (MVBs). The AAA-ATPase Vps4 regulates the ES…
View article: Infected hip prosthesis in patient with suspected Covid-19 infection
Infected hip prosthesis in patient with suspected Covid-19 infection Open
Background Infections following arthroplasty are one of the major risks during this type of surgery. Moreover, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus Disease…
View article: Genetically encoded multimode reporter of adaptor complex 3 traffic in budding yeast
Genetically encoded multimode reporter of adaptor complex 3 traffic in budding yeast Open
AP‐3 (adaptor complex 3) mediates traffic from the late Golgi or early endosomes to late endosomal compartments. In mammals, mutations in AP‐3 cause Hermansky‐Pudlak syndrome type 2, cyclic neutropenias, and a form of epileptic encephalopa…
View article: The ubiquitin hydrolase Doa4 directly binds Snf7 to inhibit recruitment of ESCRT-III remodeling factors in <i>S. cerevisiae</i>
The ubiquitin hydrolase Doa4 directly binds Snf7 to inhibit recruitment of ESCRT-III remodeling factors in <i>S. cerevisiae</i> Open
The ESCRT-III protein complex executes reverse-topology membrane scission. The scission mechanism is unclear but is linked to remodeling of ESCRT-III complexes at the membrane surface. At endosomes, ESCRT-III mediates the budding of intral…
View article: PI(3,5)P<sub>2</sub>controls vacuole potassium transport to support cellular osmoregulation
PI(3,5)P<sub>2</sub>controls vacuole potassium transport to support cellular osmoregulation Open
Lysosomes are dynamic organelles with critical roles in cellular physiology. The lysosomal signaling lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P 2 ) is a key regulator that has been implicated to control lysosome ion homeostasis,…
View article: Genetically encoded multimode reporter of adaptor protein 3 (AP-3) traffic in budding yeast
Genetically encoded multimode reporter of adaptor protein 3 (AP-3) traffic in budding yeast Open
SYNOPSIS The AP-3 (adaptor complex 3) mediates traffic from the late Golgi or early endosomes to late endosomal compartments. Here, a synthetic reporter is presented that allows convenient monitoring of AP-3 traffic, and direct screening o…
View article: Regulation of yeast ESCRT-III membrane scission activity by the Doa4 ubiquitin hydrolase
Regulation of yeast ESCRT-III membrane scission activity by the Doa4 ubiquitin hydrolase Open
ESCRT-III executes membrane scission during the budding of intralumenal vesicles (ILVs) at endosomes. The scission mechanism is unknown but appears to be linked to the cycle of assembly and disassembly of ESCRT-III complexes at membranes. …