Greg Pasco
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View article: Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD
Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD Open
Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies early in development are required to establish when sensory respon…
View article: The stability of the Autism Diagnostic Observation Schedule‐2 in children aged 14–36 months with elevated likelihood for autism
The stability of the Autism Diagnostic Observation Schedule‐2 in children aged 14–36 months with elevated likelihood for autism Open
Background This study investigated the stability of Autism Diagnostic Observation Schedule, Second Edition ( ADOS ‐2) classifications in a cohort of 304 siblings at elevated likelihood for autism ( EL ‐siblings). Methods ADOS ‐2 assessment…
View article: Mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder
Mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder Open
Background Prospective studies of autism family history infants primarily report recurrence and predictors of autism at 3 years. Less is known about ADHD family history infants and later childhood outcomes. We characterise profiles of mid‐…
View article: Parent–child similarity on autism and <scp>ADHD</scp> traits and children's social functioning and psychological well‐being at 3 years
Parent–child similarity on autism and <span>ADHD</span> traits and children's social functioning and psychological well‐being at 3 years Open
Background There is a pressing need for research on neurodevelopmental conditions to focus on predictors of resilient or positive outcomes, rather than core symptoms and impairment. One promising avenue is to consider whether child–parent …
View article: Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds
Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds Open
Background Attention‐Deficit/Hyperactivity Disorder (ADHD) is linked to strengths in creative problem‐solving amongst school‐aged children and adults. In contrast, autism (which frequently co‐occurs with ADHD) is associated with lower gene…
View article: Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits
Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits Open
Executive Functions (EFs) enable us to control attention and behaviour in pursuit of a goal. In this longitudinal study, 107 children with a family history of autism and/or ADHD (FH-autism/ADHD), and 24 children with no FH-autism/ADHD comp…
View article: Twenty‐four‐month effortful control predicts emerging autism characteristics
Twenty‐four‐month effortful control predicts emerging autism characteristics Open
Longitudinal research can assess how diverging development of multiple cognitive skills during infancy, as well as familial background, are related to the emergence of neurodevelopmental conditions. Sensorimotor and effortful control diffi…
View article: Parent‐mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze‐following task
Parent‐mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze‐following task Open
Cognitive markers may in theory be more sensitive to the effects of intervention than overt behavioral measures. The current study tests the impact of the Intervention with the British Autism Study of Infant Siblings—Video Interaction for …
View article: Mid‐childhood autism sibling recurrence in infants with a family history of autism
Mid‐childhood autism sibling recurrence in infants with a family history of autism Open
Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow‐up to mid‐childhood is rare. In population and clinical cohorts autism is not recognized in some children until school‐age or l…
View article: Assessing language in infants with an elevated likelihood or diagnosis of autism: The association between parent- versus researcher-administered measures
Assessing language in infants with an elevated likelihood or diagnosis of autism: The association between parent- versus researcher-administered measures Open
Purpose: Infants later diagnosed with autism typically have smaller vocabularies than their peers. The MacArthur-Bates Communicative Developmental Inventory (CDI) and the Mullen Scales of Early Learning (MSEL) are key tools for assessing i…
View article: Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD
Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD Open
Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies in early development are required to establish the primary of effe…
View article: The roles of sensory hyperreactivity and hyporeactivity in understanding infant fearfulness and emerging autistic traits
The roles of sensory hyperreactivity and hyporeactivity in understanding infant fearfulness and emerging autistic traits Open
Background Existing evidence indicates that atypical sensory reactivity is a core characteristic of autism, and has been linked to both anxiety (and its putative infant precursor of fearfulness) and repetitive behaviours. However, most wor…
View article: Developmental trajectories in infants and pre-school children with Neurofibromatosis 1
Developmental trajectories in infants and pre-school children with Neurofibromatosis 1 Open
Objective This prospective cohort study examines the cognitive, behavioural, ADHD trait and autism symptom development in infant and pre-school children with Neurofibromatosis 1 (NF1) compared with typically developing (TD) children withou…
View article: Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism
Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism Open
Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. …
View article: Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder
Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder Open
Background Most research on early outcomes in infants with a family history (FH) of autism has focussed on categorically defined autism, although some have language and developmental delays. Less is known about outcomes in infants with a F…
View article: Phenotypic and genetic associations between preschool fine motor skills and later neurodevelopment, psychopathology, and educational achievement
Phenotypic and genetic associations between preschool fine motor skills and later neurodevelopment, psychopathology, and educational achievement Open
BACKGROUND: Fine motor skills are heritable, comprise important milestones in development, and impairments are associated with neurodevelopmental conditions, psychiatric disorders, and poor educational outcomes.METHODS: In a pre-registered…
View article: Infant sleep predicts trajectories of social attention and later autism traits
Infant sleep predicts trajectories of social attention and later autism traits Open
Background Children with neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often experience sleep disturbances, but little is known about when these sleep differences …
View article: Infant Excitation/Inhibition Balance Interacts with Executive Attention to Predict Autistic Traits in Childhood
Infant Excitation/Inhibition Balance Interacts with Executive Attention to Predict Autistic Traits in Childhood Open
Background: Autism is proposed to be characterised by an atypical balance of cortical excitation and inhibition (E/I). However, most studies have examined E/I alterations in older autistic individuals, meaning that findings could in part r…
View article: The roles of sensory hyper and hyposensitivity in infancy in understanding later anxiety and emerging autistic traits
The roles of sensory hyper and hyposensitivity in infancy in understanding later anxiety and emerging autistic traits Open
Background: Existing evidence indicates that atypical sensory processing is a core characteristic of autism, and has been linked to both anxiety and repetitive behaviours. However, most work has used cross-sectional designs and not conside…
View article: Understanding the nature of face processing in early autism: A prospective study.
Understanding the nature of face processing in early autism: A prospective study. Open
Dimensional approaches to psychopathology interrogate the core neurocognitive domains interacting at the individual level to shape diagnostic symptoms. Embedding this approach in prospective longitudinal studies could transform our underst…
View article: Altered theta–beta ratio in infancy associates with family history of ADHD and later ADHD‐relevant temperamental traits
Altered theta–beta ratio in infancy associates with family history of ADHD and later ADHD‐relevant temperamental traits Open
Background Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prosp…
View article: A prospective study of associations between early fearfulness and perceptual sensitivity and later restricted and repetitive behaviours in infants with typical and elevated likelihood of autism
A prospective study of associations between early fearfulness and perceptual sensitivity and later restricted and repetitive behaviours in infants with typical and elevated likelihood of autism Open
Autism is diagnosed based on social and communication difficulties, restricted and repetitive behaviours and sensory anomalies. Existing evidence indicates that anxiety and atypical sensory features are associated with restricted and repet…