Greg S. Martin
YOU?
Author Swipe
View article: Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score Open
Importance The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over t…
View article: Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores
Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores Open
Background The ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO 2 /FiO 2 , hereafter P/F ratio) is a key component of the Sequential Organ Failure Assessment (SOFA) score. It reflects the severity of hypoxaemic…
View article: 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Infliximab
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Infliximab Open
This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019 (COVID-19), developed by the Infectious Diseases Society of America. The guideline panel pr…
View article: Adverse pregnancy outcomes in women with type 1 diabetes are associated with multiple alterations in the vaginal microbiome
Adverse pregnancy outcomes in women with type 1 diabetes are associated with multiple alterations in the vaginal microbiome Open
Aims/hypothesis The vaginal microbiome has been linked to adverse pregnancy outcomes, which are markedly increased in women with type 1 diabetes. To investigate this relationship, we profiled the vaginal microbiome in pregnant women with a…
View article: Consensus recommendations for the integration of critical care pharmacists on intensive care unit teams: Endorsed by the American Association of Critical‐Care Nurses, American College of Clinical Pharmacy, American Society of Health‐System Pharmacists, Institute for Safe Medication Practices, and Society of Critical Care Medicine
Consensus recommendations for the integration of critical care pharmacists on intensive care unit teams: Endorsed by the American Association of Critical‐Care Nurses, American College of Clinical Pharmacy, American Society of Health‐System Pharmacists, Institute for Safe Medication Practices, and Society of Critical Care Medicine Open
The care of critically ill patients requires an interprofessional team. Critical care pharmacists are essential members of that interprofessional team. The purpose of these Consensus Recommendations is to present standards and guidance for…
View article: 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Pemivibart for Pre-exposure Prophylaxis, Vilobelimab for Critical Illness, and Abatacept or Infliximab for Severe or Critical Illness
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Pemivibart for Pre-exposure Prophylaxis, Vilobelimab for Critical Illness, and Abatacept or Infliximab for Severe or Critical Illness Open
As the first part of several focused updates to the clinical practice guideline on the treatment and management of COVID-19 in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, the panel presen…
View article: Genes govern metabolism—Enzymes define pathways and metabolic relationships
Genes govern metabolism—Enzymes define pathways and metabolic relationships Open
Gene centric pathway mapping tools, widely used to interpret untargeted LCMS metabolomics data, may underperform because a single metabolite can generate multiple spectral features, inflating false positive rates. Classic enzymology, which…
View article: 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Vilobelimab
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Vilobelimab Open
This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019 (COVID-19), developed by the Infectious Diseases Society of America. The guideline panel pr…
View article: Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests
Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests Open
Genomic epidemiology offers insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 rapid antigen tests to identify a wide range of respiratory viruses and generate full g…
View article: The universal profile of the invariant factors of $({\mathbb Z}/n{\mathbb Z})^\times$
The universal profile of the invariant factors of $({\mathbb Z}/n{\mathbb Z})^\times$ Open
The structure of the multiplicative group $M_n = ({\mathbb Z}/n{\mathbb Z})^\times$ encodes a great deal of arithmetic information about the integer $n$ (examples include $ϕ(n)$, the Carmichael function $λ(n)$, and the number $ω(n)$ of dis…
View article: SARS-CoV-2 Infection and Childhood Islet Autoimmunity
SARS-CoV-2 Infection and Childhood Islet Autoimmunity Open
This cohort study examines whether there is a temporal association between SARS-CoV-2 infection and the development of islet autoimmunity among Australian children with a first-degree relative with type 1 diabetes.
View article: From startup to shutdown: the dramatic rise and fall of the first at-home combo test for flu and COVID-19
From startup to shutdown: the dramatic rise and fall of the first at-home combo test for flu and COVID-19 Open
Lucira health|innovation, rise, and fall.
View article: Bounding geometrically integral del Pezzo surfaces – CORRIGENDUM
Bounding geometrically integral del Pezzo surfaces – CORRIGENDUM Open
View article: Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients
Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients Open
Sepsis and septic shock are global healthcare problems associated with high mortality rates. Activation of the renin-angiotensin-aldosterone system (RAAS) is an early event in sepsis, and elevated renin may be predictive of worse outcomes.…
View article: Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog
Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog Open
The recently discovered microbiome-generated obesogen, δ-valerobetaine (5-(trimethylammonio)pentanoate), is a 5-carbon structural analog of the carnitine precursor, γ-butyrobetaine. Here, we report that δ-valerobetaine is enzymatically hyd…
View article: The Shift to Over-the-Counter Diagnostic Testing After RADx: Clinical, Regulatory, and Societal Implications
The Shift to Over-the-Counter Diagnostic Testing After RADx: Clinical, Regulatory, and Societal Implications Open
The National Institutes of Health's Rapid Acceleration of Diagnostics (RADx) program answered the call to accelerate the development of point-of-care (POC) and over-the-counter (OTC) COVID-19 tests. The widespread availability and access t…
View article: Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US
Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US Open
Importance Understanding whether there are racial and ethnic and residential disparities in prenatal telehealth uptake is necessary for ensuring equitable access and guiding implementation of future hybrid (ie, both telehealth and in-perso…
View article: Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial
Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial Open
View article: Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population
Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population Open
Background/Objective: SeptiCyte RAPID is a transcriptional host response assay that discriminates between sepsis and non-infectious systemic inflammation (SIRS) with a one-hour turnaround time. The overall performance of this test in a coh…
View article: Tree-based classification model for Long-COVID infection prediction with age stratification using data from the National COVID Cohort Collaborative
Tree-based classification model for Long-COVID infection prediction with age stratification using data from the National COVID Cohort Collaborative Open
Objectives We propose and validate a domain knowledge-driven classification model for diagnosing post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID, using Electronic Health Records (EHRs) data. Materials and Metho…
View article: Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness – post-hoc analysis from the VICTAS trial
Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness – post-hoc analysis from the VICTAS trial Open
Sepsis and septic shock remain global healthcare problems associated with high mortality rates despite best therapy efforts. Circulating biomarkers may identify those patients at risk for poor outcomes, however, current biomarkers, most pr…
View article: The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial
The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial Open
Importance Intravenous fluids are an essential part of treatment in sepsis, but there remains clinical equipoise on which type of crystalloid fluids to use in sepsis. A previously reported sepsis subphenotype (ie, group D) has demonstrated…
View article: Multiplicative groups avoiding a fixed group
Multiplicative groups avoiding a fixed group Open
We know that any finite abelian group $G$ appears as a subgroup of infinitely many multiplicative groups $\mathbb{Z}_n^\times$ (the abelian groups of size $ϕ(n)$ that are the multiplicative groups of units in the rings $\mathbb{Z}/n\mathbb…
View article: Rapid and robust identification of sepsis using SeptiCyte RAPID in a heterogenous patient population
Rapid and robust identification of sepsis using SeptiCyte RAPID in a heterogenous patient population Open
Background/Objective SeptiCyte RAPID is a transcriptional host response assay that discriminates between sepsis and non-infectious systemic inflammation (SIRS) with a one-hour turnaround time. The overall performance of this test in a coho…
View article: Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests
Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests Open
Genomic epidemiology offers important insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 antigen tests to identify a wide range of respiratory viruses and generate fu…
View article: Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study
Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study Open
Background Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Chronic…
View article: The least primary factor of the multiplicative group
The least primary factor of the multiplicative group Open
Let $S(n)$ denote the least primary factor in the primary decomposition of the multiplicative group $M_n = (\Bbb Z/n\Bbb Z)^\times$. We give an asymptotic formula, with order of magnitude $x/(\log x)^{1/2}$, for the counting function of th…
View article: Racial Differences in Accuracy of Predictive Models for High-Flow Nasal Cannula Failure in COVID-19
Racial Differences in Accuracy of Predictive Models for High-Flow Nasal Cannula Failure in COVID-19 Open
OBJECTIVES: To develop and validate machine learning (ML) models to predict high-flow nasal cannula (HFNC) failure in COVID-19, compare their performance to the respiratory rate-oxygenation (ROX) index, and evaluate model accuracy by self-…
View article: Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant
Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant Open
Limited data highlight the need to understand differences in SARS-CoV-2 omicron (B.1.1.529) variant viral load between the gold standard nasopharyngeal (NP) swab, mid-turbinate (MT)/anterior nasal swabs, oropharyngeal (OP) swabs, and saliv…
View article: Beyond Septic Shock: Who Else Requires Immediate Antibiotics?
Beyond Septic Shock: Who Else Requires Immediate Antibiotics? Open
"Beyond Septic Shock: Who Else Requires Immediate Antibiotics?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.